1. VICTR Data Management CRC Research Skills Workshop Michael Assink April 6 th, 2012

2. VICTR – CTSA at Vanderbilt The Vanderbilt Institute for Clinical and Translational Research (VICTR) is supported by the Vanderbilt Office of Research and the NIH sponsored Clinical and Translational Science Award (CTSA) Mission: transform the way ideas and discoveries make their way into patient care

3. VICTR Data Management Synthetic Derivative – De-identified database and tools, well-established Research Derivative – Fully identified clinical database, specialized for research, new and still under development [ BioVU ] – DNA Databank – uses Synthetic Derivative for analysis REDCap (integration)

4. Synthetic Derivative (SD) Indexed by a one-way hash of MRN Notes are scrubbed of names, dates are shifted Front-end tool typically used for access and analysis Services are available to help deliver results for non-standard queries (temporal queries, controls matching, etc)

5. Research Derivative (RD) Fully identified repository of integrated clinical data Integrates many data sources across the enterprise – EDW, HEO, StarPanel to name a few Available exclusively for IRB-approved studies User front-end is still under development Some REDCap integration (labs), Recruitment Tool development underway All other results are delivered by analysts on a fee-for- service basis (work <= ~1 hour can be covered by our CTSA infrastructure grant)

6. Types of Requests Suited to the RD Any study requiring identifiable information Studies needing manual review (necessitating use of MRNs in StarPanel) Situations where cohorts or other identified data already exist, and need to be matched to other variables Time-sensitive requests (recruitment) Specialized data sets not available in SD

7. RD Datasets Codes – ICD9 & CPT4 Demographics, encounters Lab results Medications (Wiz, RxStar, PAML, others) Star documents (reports, etc.)– indexed Registries – Tumor, Cardiology (STS/ACC) Star Forms, some flowsheets

8. RD Request Steps Research Data Request Form IRB application if needed, or simple verification if already in place Population definition Variable (extract) definition Rinse and repeat

9. Leveraging VICTR Resources Record Counter (RC) – part of SD but open to anyone with a Vunet ID: https://biovu.vanderbilt.edu/RC/RC.html SD – see slides in other presentation (next) RD – email or call me, or fill out a Request form at https://starbrite.vanderbilt.edu/https://starbrite.vanderbilt.edu/ (https://starbrite.vanderbilt.edu/managedata/ datarequest.html )https://starbrite.vanderbilt.edu/managedata/ datarequest.html