Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model by Gerhard Leinenga, and Jürgen Götz Sci Transl Med Volume.

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Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model by Gerhard Leinenga, and Jürgen Götz Sci Transl Med Volume 7(278):278ra33-278ra33 March 11, 2015 Published by AAAS

Fig. 1. Establishing SUS in an AD mouse model. Gerhard Leinenga and Jürgen Götz Sci Transl Med 2015;7:278ra33 Published by AAAS

Fig. 2. SUS reduces Aβ plaques in an AD mouse model. Gerhard Leinenga and Jürgen Götz Sci Transl Med 2015;7:278ra33 Published by AAAS

Fig. 3. SUS treatment reduces different Aβ species. Gerhard Leinenga and Jürgen Götz Sci Transl Med 2015;7:278ra33 Published by AAAS

Fig. 4. SUS treatment rescues memory deficits in an AD mouse model. Gerhard Leinenga and Jürgen Götz Sci Transl Med 2015;7:278ra33 Published by AAAS

Fig. 5. SUS treatment reduces Aβ in a second cohort of AD mice. Gerhard Leinenga and Jürgen Götz Sci Transl Med 2015;7:278ra33 Published by AAAS

Fig. 6. Microglial phagocytosis and lysosomal uptake of Aβ induced by SUS treatment. Gerhard Leinenga and Jürgen Götz Sci Transl Med 2015;7:278ra33 Published by AAAS

Fig. 7. Altered morphology after ultrasound but unaltered numbers of microglia in SUS-treated mice. Gerhard Leinenga and Jürgen Götz Sci Transl Med 2015;7:278ra33 Published by AAAS