1. Slides last updated: March 2015

2. There are two main types of lung cancer 1 1.Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014, accessed on 12/03/2015. 11.5% 83.6%

3. NSCLC (83.6% of lung cancer) Lung Cancer (100%) Other NSCLC (19.1% of lung cancer) Squamous cell carcinoma (18.6% of lung cancer) Adenocarcinoma (44.1% of lung cancer) NSCLC can be further divided into different sub-types 1 1.Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014, accessed on 12/03/2015.

4. NSCLC: Adenocarcinoma Adenocarcinoma Adenocarcinoma lesions are usually peripherally located 2 Most frequent in women and non-smokers 2 Some patients have EGFR/ErbB1 mutations; these patients require a specific diagnosis and treatment approach 3 1.Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014, accessed on 12/03/2015. 2. Lortet-Tieulent J, Soerjomataram I, Ferlay J, et al. Lung Cancer 2014;84:13– 22. 3. National Comprehensive Cancer Network. NCCN guidelines version 5.2015 for non-small cell lung cancer. Available online at: http://www.nccn.org/professionals/physician_gls/pdf/nscl.pdf [accessed 12/03/2015]. 44.1% 1

5. 18.6% 1 NSCLC: Squamous cell carcinoma Squamous Cell Carcinoma 2 Squamous Cell Carcinoma lesions are generally centrally located, near bronchi Tends to spread locally Closely correlated with smoking 1.Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014, accessed on 12/03/2015. 2. Heighway J & Betticher DC. Atlas Genet Cytogenet Oncol Haematol. February 2004. 18.6% 1

6. 2.0% 1 NSCLC: Large cell carcinoma Large Cell Carcinoma Comprised of undifferentiated cells 2 Lesions are usually peripherally located but can occur anywhere 2 High tendency to metastasize 2 1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014, accessed on 12/03/2015. 2. Heighway J & Betticher DC. Atlas Genet Cytogenet Oncol Haematol. February 2004. 2.0% 1

7. 19.1% 1 NSCLC: Other Other, including Not Otherwise Specified (NOS) or Unknown A classification of NOS or unknown is usually due to ineffective sampling and examination 2 This classification is expected to decline in use due to more accurate biopsies and advances in immunohistochemistry and biomarker testing 2 1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014, accessed on 12/03/2015. 2. Righi L, Graziano P, Fornari A, et al. Cancer 2011;117:3416 ‒ 3423.