1. How and Why Drugs Work Chapter 5

2. Intended and Unintended Effects of Drugs Intended responses: - Reason for using the drug Unintended responses: - Side effects The main distinction between intended responses and side effects depends on the therapeutic objective.

3. Common Side Effects of Drugs Nausea or vomiting Changes in mental alertness Dependence - Withdrawal Allergic reactions Changes in cardiovascular activity

4. Common Side Effects of Drug

5. Dose-Response Many factors can affect the way an individual responds to a drug, including the following: - Dose - Tolerance - Potency

6. Dose-Response (continued) Additional factors - Pharmacokinetic properties: Rate of absorption Manner distributed throughout the body Rate metabolized and eliminated - Form of the drug - Manner in which the drug is administered

7. Dose- Response Curve

8. Margin of Safety The range in dose between the amount of drug necessary to cause a therapeutic effect and a toxic effect.

9. Potency vs. Toxicity Potency: The amount of drug necessary to cause an effect Toxicity: The capacity of a drug to do damage or cause adverse effects in the body

10. Drug Interaction Additive effects -Summation of effects of drugs taken concurrently Antagonistic (inhibitory) effects -One drug cancels or blocks effects of another Potentiative (synergistic) effects -Effect of a drug is enhanced by another drug or substance

11. Pharmacokinetic Factors That Influence Drug Effects Administration Absorption Distribution Inactivation Biotransformation and elimination

12. Forms and Methods of Taking Drugs Oral ingestion Inhalation Injection Topical application

13. Distribution Most drugs are distributed throughout the body in the blood. It takes approximately 1 minute for a drug to circulate throughout the body after it enters the bloodstream. Drugs have different patterns of distribution depending on their chemical properties.

14. Required Doses for Effects Threshold dose: The minimum amount of a drug necessary to have an effect Plateau effect: The maximum effect a drug can have regardless of the dose Cumulative effect: The buildup of drug concentration in the body due to multiple doses taken within short intervals

15. Time-Response Factors The closer a drug is placed to the target area, the faster the onset of action. Acute drug response: -Immediate or short-term effects after a single drug dose Chronic drug response: -Long-term effects after a single dose

16. Biotransformation Biotransformation: The process of changing the chemical or pharmacological properties of a drug by metabolism. The liver is the major organ that metabolizes drugs in the body. The kidney is the next most important organ for drug elimination.

17. Physiological Variables That Modify Drug Effects Age Gender Pregnancy © Pixtal/SuperStock

18. Adaptive Processes Tolerance: Changes causing decreased response to a set dose of a drug Dependence: The physiological and psychological changes or adaptations that occur in response to the frequent administration of a drug Withdrawal

19. Adaptive Processes

20. Tolerance Reverse tolerance (sensitization): Enhanced response to a given drug dose; opposite of tolerance Cross-tolerance: Development of tolerance to one drug causes tolerance to related drugs

21. Drug Dependence Physical Dependence (e.g.,withdrawal and rebound) Psychological Dependence (e.g., craving)

22. Psychological Factors Affecting Drug Effect Individual’s mental set Placebo effects

23. Addiction and Abuse The use of the term addiction is sometimes confusing. It is often used interchangeably with dependence, either physiological or psychological in nature; other times, it is used synonymously with the term drug abuse. A more accurate definition is the compulsive drug use despite negative consequences.

24. Addiction and Abuse (continued) Factors affecting variability in dependence/addiction: -Hereditary factors (genetic variants); responsible for 40–60% vulnerability -Drug craving

25. Addiction and Abuse (continued) Other factors contributing to drug use patterns: -Positive versus negative effects of drug -Peer pressure -Home, school, and work environment -Mental state