1. Slides last updated: March 2015

2. 1.Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray, F. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr, accessed on 11/03/2015. Lung cancer incidence and mortality Lung cancer is one of the most common cancers, with 1.8 million new cases in 2012 worldwide 1 Lung cancer is the most common cause of death from cancer, responsible for 19.4% of all cancer deaths in 2012 1

3. Rates of lung cancer incidence and mortality differ worldwide 1 58% of new lung cancer cases occur in developing countries Highest lung cancer rates are found in Northern America Lung cancer is the most common cancer in men and the third most common in women Lowest lung cancer rates are found in Western Africa Lung cancer is the 8 th most common cancer in this region Northern America Micronesia Eastern Asia More developed regions Western Europe Central and Eastern Europe Southern Europe Northern Europe Australia/New Zealand Polynesia World Western Asia Less developed regions South-Eastern Asia Caribbean Southern Africa South America Melanesia Northern Africa South-Central Asia Central America Eastern Africa Middle Africa Western Africa 806040200 406080 MaleFemale Incidence Mortality Estimated age-standardized rates (World) per 100,000 1.Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray, F. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr, accessed on 11/03/2015.

4. Lung Prostate Colorectum Stomach Liver Bladder Oesophagus Non-Hodgkin lymphoma Kidney Leukaemia Lip, oral cavity Pancreas Brain, nervous syst. Larynx Melanoma of skin 2000150010005000 ASR (W) rate per 100,000 Breast Colorectum Lung Cervix uteri Stomach Corpus uteri Ovary Thyroid Liver Non-Hodgkin lymphoma Pancreas Leukaemia Oesophagus Kidney Brain, nervous syst. 0500100015002000 ASR (W) rate per 100,000 Lung 1,242,000 1,099,000 Lung 583,000 491,000 Rates of lung cancer incidence differ between men and women 1 Incidence Mortality 1.Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray, F. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr, accessed on 11/03/2015.

5. Five-year survival trend Breast cancer Colo- rectal cancer Lung cancer High unmet medical need Survival rates for lung cancer are generally low 1 Survival rates vary depending on stage at diagnosis. The later the stage of diagnosis the lower the survival rates tend to be. PERCENTAGE (%) 1. SEER. Fast Stats Online. 5 year survival by diagnosis. 1975-2012. All races. All ages. Male and Female. Available online: seer.cancer.gov/faststats/selections.php, accessed on 09/07/2015. Prostate cancer

6. NSCLC (83.6% of lung cancer) Lung Cancer (100%) NSCLC makes up approximately 84% of lung cancer 1 Other NSCLC (19.1% of lung cancer) Squamous cell carcinoma (18.6% of lung cancer) Adenocarcinoma (44.1% of lung cancer) 1.Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014, accessed on 12/03/2015.

7. The distribution of NSCLC subtypes is changing 1 Since the 1980’s, squamous cell carcinomas have become relatively less common Meanwhile, adenocarcinomas have become relatively more common 1. Devasa S, Bray F, Vizcaino A, et al. Int. J. Cancer 2005: 117, 294–299 The reasons for these changes are unclear, but may be due to changes in the composition and filtering of cigarettes