1. Crimean-Congo hemorrhagic fever virus Syeda Zainab Ali Bukhari 12-10125

2. Hemorrhagic fever
A viral disease, disrupts clotting of the blood thus patients develop uncontrolled bleeding

3. CCHF (Crimean–Congo hemorrhagic fever)
CCHF (Crimean–Congo hemorrhagic fever) is a widespread tick-borne viral disease, caused by domestic and wild animals
Virus circulates in the body of an infected animal up to 1 week. Clinical disease is rare in infected animals but symptoms could be severe in infected humans.

4. Crimean Congo hemorrhagic virus
The virus which causes CCHF is a Nairovirus.
It is a ssRNA virus
Sporadic infection in people is caused by Hyalomma tick bite
Many birds are resistant to this disease. Ostriches are susceptible

6. Likely to infect…
Majority of cases are seen in those involved with the livestock industry i.e. agriculture workers, slaughterhouse workers and veterinarians.
Blood, sweat or saliva of infected patient or infected tissues
Infected from a tick bite.

7. Symptoms
Fever, myalgia (aching muscles), dizziness, neck pain and vomiting, backache, headache, sore eyes and photophobia.
There may be nausea, vomiting and sore throat earlier on which may lead to diarrhea and generalized abdominal pain.

8. Symptoms Hepatomegaly (liver enlargement) may also result
Other clinical signs may include tachycardia (fast heart rate), lymphadenopathy (enlarged lymph nodes) and a petechial rash (a rash caused by bleeding into the skin).

9. CCHF virus spreads after 1-3 day incubation period
CCHF virus spreads after 1-3 day incubation period. After 9-10 days patients start recovering. The mortality rate of CCHF is 30%.

11. Diagnosis
ELISA is used for the detection of IgG and IgM in the blood of the patient from about six days of illness.
Real time PCR
Virus isolation from blood samples

12. Treatment
An antiviral drug is given, ribavirin. Both oral and intravenous formulations.
Patient is kept in isolation and constantly monitored for blood volumes.
Immune plasma from recovered patients for therapeutic purposes has been used.

13. Prevention and Control
Isolate the patient.
Inform and educate people in your vicinity.
Personal protective measures. Avoid going to the areas where tick vectors are abundant.

14. Prevention and Control
Use repellents on the skin e.g. DEET.
Specimens of blood or tissues specimens should be handled carefully.
Needles and other surgical instruments should be safely disposed

15. Thank you :)