1. Status Report: Cyberinfrastructure Strategic Planning Activities BIO Advisory Committee November 17, 2005 Manfred Zorn, Chris Greer, Liz Blood, Sally O’Connor

2. Recent Events Office of Cyberinfrastructure established Search for Office Director – position posted Advisory Committee for Cyberinfrastructure Agency-wide Strategic Planning Process Underway Cyberinfrastructure Council established

3. CI Strategic Planning Ch. 1: Call to Action Ch. 2: Strategic Plan for High Performance Computing Ch. 3: Strategic Plan for Data, Data Analysis & Visualization Ch. 5: Strategic Plan for Education & Workforce Development Ch. 4: Strategic Plan for Collaboration, Communication & Remote Access CI “Vision” document

4. Charge to HPC Team to enable petascale science and engineering through the deployment and support of a world-class HPC environment comprising the most capable combination of HPC assets available to the academic community. Draft plan for 5-year strategy

5. Draft HPC Plan Specification, Acquisition, Deployment and Operation of Science-Driven HPC Systems Architectures Development and Maintenance of Supporting Software: New Design Tools, Performance Modeling Tools, Systems Software, and Fundamental Algorithms. Development and Maintenance of Portable, Scalable Applications Software Released September 26, 2005

6. HPC Team Progress High Performance Computing System Acquisition: Towards a Petascale Computing Environment for Science and Engineering NSF 05-625 Posted September 27, 2005 Initial Hardware Acquisition

7. Current HPC Team Members Abhi Deshmukh (ENG) Manfred Zorn (BIO) Frank Scioli (SBE)Debasish Dutta (EHR) Vladimir Papitashvili (OPP) Clifford Jacobs (GEO) Almadena Chtchelkanova (CISE) Celeste Rohlfing (MPS) Stephen Meacham (OCI)Jose Muñoz (OCI) Ex officio Deb Crawford (OCI)

8. Continuing efforts of HPC Team Continue developing details of the HPC requirements in the various domains Develop process to pick a representative set of six or seven application benchmarks for the FY07 HPC acquisition Other HPC issues: –catalyze the development of new HPC codes –transform existing approaches using algorithms better suited to the new types of HPC systems

9. BIO HPC efforts Define BIO continuum of HPC needs –Match BIO applications to HPC architecture Develop strategies to overcome barriers –Sociological barriers, e.g, data ownership –Technical barriers, e.g., data formats, metadata Other HPC issues: –catalyze the development of new HPC codes –transform existing approaches using algorithms better suited to the new types of HPC systems

10. Charge to Data Team Provides data resources, tools, and services Considers NSF portfolio Promotes interoperability and collaboration Promotes interagency partnerships Defines a comprehensive programmatic and policy framework Develop a 5-year strategy that:

11. Data Team Members Jim French (CISE) Chris Greer (BIO) Fillia Makedon (OCI)Dan Newlon (SBE) Nigel Sharp (MPS)Sylvia Spengler (CISE) Ex officio Deb Crawford (OCI) David Lightfoot (SBE)

12. Data Team Timeline Aug. 2, 2005 Organizational meeting Sep. 6Outline to CI Council Sep./Oct.Directorate input Nov.Full draft of strategic plan Jan., 2006Comments on strategic plan, Draft implementation plan

13. Data Team – Emerging Themes The National Science Foundation envisions a cyberinfrastructure universe in which data are routinely deposited in convenient locations, are regularly and easily consulted in well- documented form by specialists and non- specialists alike, are openly accessible while suitably protected, and are reliably preserved. Vision:

14. Data Team – Emerging Themes Working in partnership with the community and with other US and international agencies and organizations, NSF will promote the development of a system of digital data collections that is as robust as that that exists now for preservation of information in the print realm.. Strategy:

15. Charge to COVO Team  identifies the unique scientific opportunities afforded by collaboratories, observatories and virtual organizations (COVO),  describes the resources, tools and services to enable functionally- complete knowledge environments that are highly-interactive, widely accessible, and easily usable;  identifies opportunities to realize economies of scale and scope;  promotes interoperability and federalization;  promotes an effective, inclusive community governance strategy;  encourages strong partnerships among NSF directorates;  leverages investments made by other federal agencies and organizations, including the private sector; and  defines a flexible programmatic and policy framework Develop 5-year strategy that:

16. COVO Team Members Art Goldstein (GEO) Liz Blood (BIO) Bonnine Thompson (INT)Tom Baerwald (SBE) Randy Ruchti (MPS)Chuck Baudin (MPS) Kevin Thompson* (OCI)Joy Pauschke* (ENG) Ex officio Deb Crawford (OCI) Michael Turner (MPS)

17. COVO Team Timeline Oct. 19, 2005 Organizational meeting Nov. 14Outline to CI Council Nov./Dec.Directorate input Dec 30Full draft of strategic plan Feb 3, 2006Comments on strategic plan, Draft implementation plan

18. COVO Team – Emerging Themes Draft outline complete – pending CI Council approval –Vision –Guiding Principles –Strategies

19. Learning & Workforce Development (LWD Team) Team is now being formed, short timeline anticipated Ex Officio: Jim Collins (BIO), Deb Crawford (OCI) Sally O’Connor (BIO) will participate Other team members are being confirmed

20. Draft Charge to LWD Team Identifies CI-enabled opportunities in learning and workforce development Ensures that current and future generations of scientists and engineers have the necessary competencies Describes the resources, tools and services for community-developed learning environments Prepare a five-year strategic plan that:

21. Draft Charge to LWD Team (cont’d) Encourages strong partnerships among NSF directorates Leverages investments made by other agencies and the private sector Defines a flexible programmatic and policy framework for prioritizing and managing investments.

22. Challenges on Different Architectures “Loosely Coupled”“Massively Parallel” 1 101001000 Genome Annotation Molecular dynamics of protein machine Stochastic metabolic / regulatory network Small ODE Metabolic network Genome Assembly Whole genome protein threading Physics- based protein folding Population- based whole cell model