1 NHLBI Strategic Visioning Process: Charting Our Future Together Dr. Lenora JohnsonDirectorOffice of Science Policy, Engagement, Education, and CommunicationsFebruary 11, 2015NHLBI’s Strategic Visioning process is designed to engage the entire NHLBI community in identifying the most Compelling Questions and Critical Challenges in heart, lung, blood, and sleep research. We want to ensure that our partners help determine NHLBI’s future direction, and we welcome your participation in an ongoing process that will inform our priority setting, decision making, and resource allocation.
2 NHLBI Strategic Visioning Process: Charting Our Future Together Dr. Stephen C. MockrinDirectorDivision of Extramural Research ActivitiesDr. James KileyDirectorDivision of Lung DiseasesFebruary 11, 2015
3 Objectives for Today’s Webinar Strategic Visioning Process -- OverviewHow to contribute to the Strategic Visioning ProcessStrategic Goal AreasCompelling Questions (CQs) and Critical Challenges (CCs)Strategic Visioning ForumThere are two major objectives for this presentationthe 1st is to describe the overall strategic visioning processand the second is to describe your participation – in terms ofwhen you can participatewhere you can participatehow you can contributeThe three key elements of the Strategic Visioning Process arethe strategic goal areasthe Compelling Questionsand the Critical ChallengesThere are four strategic goal areas and within each of these strategic goals there will be a number of compelling questions and critical challenges.
4 Strategic Visioning Process – Overview and Community Input TimelineFall 2014Early 2016Fall 2014Winter 2015Spring 2015Summer 2015Summer 2015Fall 2015Early 2016NHLBI Synthesizes Input and Releases Draft Strategic Visioning Scientific PrioritiesNHLBI and Advisory Groups Plan Strategic Visioning FrameworkNHLBI Releases Strategic Visioning FrameworkNHLBI Community SubmitsCQs and CCsNHLBI Community Provides InputNHLBI and Advisory Groups Refine Scientific PrioritiesNHLBI Releases Strategic Visioning Scientific PrioritiesThis figure summarizes the SV process, starting from the Fall of 2014 on the left and proceeding to early 2016 on the far right. In terms of timing, we have divided the process into 7 stages (shown as boxes) and labeled them by seasons. You will notice two highlighted boxes – Spring 2016 and Summer 2016 – which are the stages you can provide input.In stage 1 – the Fall of we solicited ideas from the National Heart, Lung, and Blood Advisory Council, the NHLBI Board of Extramural Experts, and the NHLBI staff. This process informed the development of a Framework that details why and how we would like to solicit community input and includes examples of Questions and Challenges.In stage 2 – Winter 2015 – we will launch a Strategic Visioning website, make the Strategic Visioning Framework available, and begin the public input process. In stage 3 – Spring The NHLBI community contributes Questions and Challenges. There will be multiple channels for input, including , regular mail, and a platform called the Strategic Visioning Forum. All modes will allow contributors to submit new Questions and Challenges. The Strategic Visioning Forum will also allow participants to comment and vote on Questions and Challenges that were already contributed.In stage 4 -- Summer 2015 – The submissions will be reviewed and synthesized, and a Draft NHLBI Strategic Vision Scientific Priorities document will be released for public comment.In stage 5 – also in the Summer 2015 – The public will comment on the Draft Strategic Vision Scientific Priorities document.In stage 6 – Fall the NHLBI, working with its scientific advisory groups, will select a final prioritized list of Questions and Challenges.In stage 7 -- Early The final Strategic Vision Scientific Priorities document will be published and disseminated.Spring 2015Compelling Questions and Critical Challenges Submitted for NHLBI ConsiderationSummer 2015Public Comment on Draft Strategic Visioning Scientific Priorities
5 Strategic Visioning Goal Areas Goal 1: Promote Human HealthTo expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.Goal 2: Reduce Human DiseaseTo extend our knowledge of the pathobiology of heart, lung, blood, and sleep disorders and enable clinical investigations that advance the prediction, prevention, preemption, treatment, and cures of human disease.Goal 3: Advance Translational ResearchTo facilitate innovation and accelerate research translation, knowledge dissemination, and implementation science that enhances public health.Goal 4: Develop Workforce and ResourcesTo enable and develop a diverse biomedical workforce equipped with the essential research resources to pursue emerging opportunities in science. Goal 1: is to expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.This goal addresses the intrinsic value of an in-depth understanding of normal biology and physiology as essential to sustaining and enhancing human health.The intent of this goal is to explore normal human physiology at all levels, spanning the molecular, cellular, individual, and population levels.It encompasses basic, preclinical, and clinical research.Goal 2: is to extend our knowledge of the pathobiology of heart, lung, blood, and sleep disorders and enable clinical investigations that advance the prediction, prevention, preemption, treatment, and cures of human disease.It focuses on elucidating the fundamental mechanisms and molecular pathways of disease to enable interventions.This goal may span basic, preclinical, and clinical research, including clinical trials.Goal 3: is to facilitate innovation and accelerate research translation, knowledge dissemination, and implementation science that enhances public health.Goal 3 aims to facilitate and accelerate activities that promote the progression of research findings and technologies from the bench into clinical practice.It encompasses translation across the entire research spectrum (sometimes characterized as T0-T4), bridging basic to clinical, clinic to practice, and population to public health impact.Goal 4: is to enable and develop a diverse biomedical workforce equipped with the essential research resources to pursue emerging opportunities in science.It focuses on enabling the biomedical workforce to fully capitalize on emerging scientific opportunities:(1) by equipping today’s workforce with new skills and the necessary tools and resources; and(2) by cultivating a diverse next generation trained in cutting-edge science and the requisite multi-disciplinary skills.This goal spans all phases of research including basic, clinical, translational, and population studies.
6 Overview of Compelling Questions (CQs) and Critical Challenges (CCs)
7 What is a Compelling Question? What is a Critical Challenge? Strategic Visioning Process Objective: Develop Compelling Questions and Critical ChallengesObjective: Develop compelling questions (CQs) and critical challenges (CCs) to guide the Institute’s priorities, decision-making, and resource allocation over the next decade.What is a Compelling Question?A Compelling Question:Probes a specific line of inquiryIdentifies a crucial knowledge gap or opportunityTranscends an individual investigator- initiated programRequires NHLBI facilitationIs feasible within the next decadeWhat is a Critical Challenge?A Critical Challenge:Is a barrier or an impediment that hinders scientific progressOvercoming a critical challenge:Requires enabling tools, infrastructure or resourcesWill result in significant impactIs feasible to overcome within the next decadeFor each Strategic Goal, we will collectively identify compelling questions and critical challenges which, if answered or overcome, will significantly advance HLBS research.A compelling question is intended to probe a specific line of inquiry, identifies a crucial scientific knowledge gap, transcends an individual investigator-initiated program, requires NHLBI’s facilitation in order to be answered, and is feasible within the next decade.A critical challenge, on the other hand, is a barrier to an unexplored area or an impediment that hinders scientific progress. Critical challenges will generally identify needed resources, infrastructure, or tools that could catalyze major scientific advances if they are overcome.
8 Illustrative CQs and CCs Jim and Steve PresentNotes:Transition Slide
9 Goal 1: Promote Human Health - To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.Illustrative Compelling QuestionCompelling Question 1.1: What are the “protective” genetic variants that are associated with a resilient, healthy phenotype or that mediate an intrinsic “resistance” to the influence of risk factors that accelerate HLBS diseases throughout the human lifespan?Illustrative Critical ChallengeCritical Challenge 1.1: There is a need for the NHLBI to catalyze the development of tools and shared data resources – the “Heart, Lung, and Blood Systems Biology Connectome” – that facilitates the systematic characterization of the dynamic changes in complex molecular interactions that sustain normal HLB system functions under various physiological conditions. This open resource would comprehensively catalogue these genomic, epigenomic, and metabolic pathways, as well as provide tools to systematically probe them.Examples are for Goal 1The examples are just examples and do not indicate any institute priorities.More Illustrative examples can be found on the Strategic Visioning WebsiteIn addition to your question, you will also be asked to submit some additional information about compelling question or critical challenge.FeasibilityImpact
10 Gathering Community Feedback Strategic Visioning Forum for Submission of CQs and CCs
11 Strategic Visioning Forum Strategic Visioning Forum, a digital crowdsourcing tool, allows us to gain the broadest input possible.Benefits of crowdsourcingGenerate innovative ideasGet ideas from new and diverse sourcesEngagement of participantsNHLBI Strategic Visioning WebsiteStrategic Visioning ForumThe Strategic Visioning Forum will be a tool used to facilitate the ideation process in order to solicit internal stakeholder feedback.