1. Ultrasonic imaging parameters ~Attenuation coefficient Advisor: Pai-Chi Li Student: Mei-Ru Yang Wei-Ning Lee

2. ****Attenuation predicted by Biot’s theory (bone) ****Ultrasound attenuation in other tissues(breast dermis…) ***Ultrasound attenuation in bones (one transducers) ********** **** Ultrasound attenuation in bones (two transducers) 50 10173101 Attenuation coefficient TotalProcessSystemApparatusMethodCircuitDevice Ultrasound attenuation in signal processing *********

3. 引證族譜圖 Year EnterpriseVammenJorgensenLaugierBerger 6328695 1990 1992 2001 6086538 2000 1999Paper 1 Paper 2 Paper 3 Wear Paper 4 Paper 5 1998 1993 WSUMSSM Paper 6 Paper 7 Paper 8 1984 Yale U.Irvine Paper 9 5259384 5879301 5785656

4. Methods and Apparatus One transducer (pulse-echo mode) –Spectral - Shift –Log Spectral – Difference –Backscattering Two transducers(one transmitter and one receiver)

5. One Transducer Simplify the handling and avoid potential errors to misalignment or mismatching Differentiate the attenuation coefficients of adjacent tissues Problem : renewed reflection –The delay should preferably by adapted to space any mirror images of pronounced spikes away from the region to be analysis

6. Cont’d Log amplitude(dB) distance 1 MHz 5 MHz T S C T C B C

7. T Soft tissue Hard tissue Interpose a delay line (50mm) T delay line

8. Two Transducers Through-transmission method A pair of transducers coaxially in a water tank Submerge a sample between the transducers Signals were recorded both with and without the specimen in the acoustic path Can’t separate the contribution caused by effects in the soft tissue from the contributions caused by effects in the bone tissue

9. Apparatus t 1, t 2 : pulse-echo mode TR Water tank specimen

10. Spectral Shift Technique : transmitting pulse power spectrum : receiving pulse power spectrum T: time constant

11. Log Spectral Difference Technique

12. Cont’d Attenuation obeys Use amplitude and phase information of the pulse Ultrasound reflection at the water-specimen interface  produce error A w (f) ： amplitude spectrum with water path only A s (f) ： amplitude spectrum with the specimen inserted L : specimen thickness

13. Cont’d Given “n”, calculate attenuation coefficient β Minimize

14. Diffraction Correction Diffraction effect on attenuation estimate due to the two media with different ultrasound velocities Experimental Diffraction Correction technique –Using the spectrum of the reference media, i.e. water Ad(f, z) ： diffraction magnitude transfer function

15. Cont’d Fresnel parameter : S=Sa=zλ a /a 2 ensures that the water-specimen-water and water- only paths undergo equivalent diffraction effects Then, ： wavelength in water ： wavelength in specimen

16. Difficulties Theoretical value –Biot’s theory (for bone) –Ultrasound properties of mammalian tissues –Numerous parameters are required for the computation (bulk modulus, shear modulus, transmission coefficient, etc.) Three phantoms –Actual attenuation coefficients are unknown

17. Strategies for Attenuation Estimate Qualitative analysis –Use various specimens with largely different hardness –Observe the attenuation trend –Relationship between attenuation and frequency Quantitative analysis –Dispersion & reflection –Diffraction correction

18. Experiment Transducers: 3.5 MHz 5 MHz 7.5 MHz Pulse receiver Oscilloscope A/D: GaGe fs=100 MHz LabView Phantom

19. Preliminary Results Transmitting mode –Signal type: Gaussian –4 cycles, continuous –PRI: 300μs –Output voltage: ± 5 V Receiving mode –Capture length: 5 μs –No. of PRI: 1 –Sampling rate: 50 MHz

20. Cont’d

21. References Paper1 : “Attenuation coefficient and speed of sound in immature and mature rat cartilage: a study in the 30-70 MHz frequency range,” IEEE Ultra. Sym., 1999. Paper 2: “Prediction of ultrasound attenuation in cancellous bones using poroelasticity and scattering theories,” IEEE Ultra. Sym., 2001. Paper 3: “Ultrasonic wave propagation in cancellous and cortical bone: prediction of some experimental results by Biot’s theory,”J. Acous. Soc. Am.,Vol. 91, pp. 1106-1111, 1992. Paper 4: “Frequency dependence of ultrasonic backscatter from human trabecular bone: Theory and experiment,” J. Acous. Soc. Am. Vol.106, pp. 3659-3664, 1999 Paper 5: “Anisotropy of attenuation and backscatter in cancellous bone” IEEE Ultra. Sym., pp. 1325-1328, 1999.

22. Cont’d Paper6: Ping He, “Acoustic parameter estimation based on attenuation and dispersion measurements,” Proc. IEEE/EMBS, Oct. 29, Nov. 1, 1998 Paper7: Wei Xu, Jonathan J. Kaufman, “Diffraction correction methods for insertion ultrasound attenuation estimation,” IEEE Trans. On Biomedical Engineering, vol. 40, No. 6, June 1993 Paper8: Roman Kuc, “Estimating acoustic attenuation from reflected ultrasound signals: comparison of spectral-shift and spectral-difference approaches,” IEEE Trans. On Acoustics, Speech, and Signal Processing, vol. ASSP-32, No. 1, Feb. 1984 Paper9: Leeman, Ferrari, Jones, and Fink, “Perspectives on attenuation estimation from pulse-echo signals,” IEEE Trans. On Sonics and Ultrasonics, Vol. SU-31, No. 4, July 1984 Paper10: Parker, Lerner, and Waag, “Comparison of techniques for in vivo attenuation measurements,” IEEE Trans. On Biomedical Engineering,, vol. 36, No. 12, Dec 1988