1. Fruits and Vegetables and Lung Cancer Publication Smith-Warner, S. A., et al. Fruits, vegetables and lung cancer: a pooled analysis of cohort studies. International Journal of Cancer. 2003; 285:769- 776.

2. Nurses’ Health Study Netherlands Cohort Study New York State Cohort Iowa Women’s Health Study Canadian National Breast Screening Study Adventist Health Study Alpha-Tocopherol Beta-Carotene Cancer Prevention Study Health Professionals Follow-up Study Cohort Studies Included in the Pooled Analysis of Fruits, Vegetables and Lung Cancer Total = 430,281 # cases = 3,206 Smith-Warner, et al. 2003

3. Study Baseline # of Cohort Cases Adventist Health (W) 17,990 20 Adventist Health (M)12,526 31 ATBC 6,771 298 Canadian National 56,837149 Health Professionals44,350244 Iowa Women’s 33,828433 Netherlands Cohort (W) 62,412131 Netherlands Cohort (M) 58,279843 New York State (W) 21,045130 New York State (M) 27,936392 Nurses’ Health (a) 88,307156 Nurses’ Health (b) 68,307379 Cohort Studies in the Pooled Analysis of Fruits and Vegetables and Lung Cancer Smith-Warner, et al 2003

4. Median Fruit and Vegetable Intakes (g/d) Study Total Total Fruits Vegetables Adventist Health (W)354162 Adventist Health (M)310 151 ATBC 121 94 Canadian National 314221 Health Professionals 300 293 Iowa Women’s 339 195 Netherlands Cohort (W) 207 164 Netherlands Cohort (M) 155 157 New York State (W) 290188 New York State (M) 258 186 Nurses’ Health (a) 272150 Nurses’ Health (b) 329259 Smith-Warner, et al 2003

5. Fruits and Vegetables and Lung Cancer: Pooled Multivariate RR by Quintile Quintile Total Fruits Total Veg. RR (95% CI) RR (95% CI) 1 1.00 1.00 2 0.82 (0.73-0.91) 0.94 (0.83-1.05) 3 0.78 (0.67-0.90) 0.87 (0.76-0.99) 4 0.83 (0.74-0.94) 0.90 (0.80-1.02) 5 0.77 (0.67-0.87) 0.88 (0.78-1.00) p for trend <0.001 0.12 p for het. for Q5 0.56 0.76 Smith-Warner, et al 2003

6. Relative Risk.1.51510 Combined NHS(b) NHS(a) NYS_m NYS_f NLCS_m NLCS_f IWHS HPFS CNBSS ATBC AHS_m AHS_f Study-Specific Multivariate Relative Risks of Lung Cancer and Fruit Intake (Quintile 5 vs. 1) Smith-Warner et al, 2003

7. Relative Risk Combined Study-Specific Multivariate Relative Risks of Lung Cancer and Vegetable Intake (Quintile 5 vs. 1) Smith-Warner et al, 2003

8. Pooled Multivariate Relative Risk of Lung Cancer and Total Fruit Intake Relative Risk Intake (g/day) 0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 <100 100 - <200200 - <300300 - <400 >400 # cases: 799 765 581 417 444 Smith-Warner et al, 2003

9. Pooled Multivariate Relative Risk of Lung Cancer and Total Vegetable Intake Intake (g/day) Relative Risk # cases: 631 1222 657 282 214 0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 <100 100 - <200200 - <300 300 - <400 >400

10. Pooled Multivariate Relative Risks of Lung Cancer and Specific Foods Food RR (95% CI) >1/2 vs. 0 serving/d Apples, pears 0.80 (0.68-0.94) Bananas 1.04 (0.89-1.22) Oranges, tangerines 0.74 (0.58-0.95) Orange/grapefruit juice 0.82 (0.71-0.94) Carrots 0.91 (0.75-1.11) Tomatoes 0.83 (0.67-1.03) Smith-Warner, et al 2003

11. Total Fruits and Lung Cancer: Pooled Multivariate RR by Smoking Status Quartile Never Past Current n=259 n=981 n=1915 1 1.00 1.00 1.00 2 0.72 0.85 0.83 3 0.78 0.85 0.85 4 0.59 0.85 0.82 (0.34-1.04) (0.69-1.05) (0.68-0.99) p for trend 0.16 0.43 0.02 p for het. due to smoking status for Q4 = 0.39 Smith-Warner, et al 2003

12. Total Vegetables and Lung Cancer: Pooled Multivariate RR by Smoking Status Quartile Never Past Current n=259 n=981 n=1915 1 1.00 1.00 1.00 2 0.94 0.97 0.84 3 1.02 0.93 0.87 4 0.90 0.97 0.86 (0.58-1.40) (0.76-1.24) (0.74-1.00) p for trend 0.75 0.83 0.14 p for het. due to smoking status for Q4 = 0.72 Smith-Warner, et al 2003

13. Total Fruits and Lung Cancer: Pooled Multivariate RR by Cell Type Quartile Adeno. Small Squamous n=956 n=538 n=901 1 1.00 1.00 1.00 2 0.84 0.78 0.70 3 0.84 0.92 0.74 4 0.84 0.93 0.75 (0.71-0.99) (0.71-1.23) (0.59-0.96) p for trend 0.10 0.71 0.01 p for common effects by cell type for Q4 = 0.51 Smith-Warner, et al 2003

14. Total Vegetables and Lung Cancer: Pooled Multivariate RR by Cell Type Smith-Warner, et al 2003 Quartile Adeno. Small Squamous n=956 n=901 n=659 1 1.00 1.00 1.00 2 0.88 1.04 0.86 3 0.97 1.07 0.86 4 0.91 0.98 0.94 (0.75-1.11) (0.77-1.26) (0.78-1.12) p for trend 0.53 0.92 0.84 p for common effects by cell type for Q4 = 0.63