1. BIOLOGY FORM 5
1.2 - The Circulatory
System

2. THE HUMAN HEART

3. LEARNING OUTCOMES
Explain how blood is propelled through the human circulatory system,
Explain briefly how blood pressure is regulated,
Compare & contrast the circulatory systems in the following humans, fish & amphibians.
Conceptualise the circulatory system in humans.

4. The Structure & Function of the Human Heart
The 3rd component (PUMP) of circulatory system
Situated between the two lungs in the thoracic cavity
The organ responsible for generating the pressure to pump blood through the network of blood vessels
A Dark red, cone-shaped, muscular organ
Weight : grams in an adult
Made up of four chambers – two upper thin-walled atria, two lower thick-walled ventricles

7. HUMAN HEART SEMI-LUNAR VALVE SUPER VENA KAVA AORTA RIGHT ATRIUM
PULMONARY ARTERY
PULMONARY VEIN
PULMONARY VEIN
LEFT ATRIUM
TRICUSPID VALVE
RIGHT VENTRICLE
LEFT VENTRICLE
HUMAN HEART

8. SEMI-LUNAR VALVE
BICUSPID VALVE
TRICUSPID VALVE

9. The valves in the heart ensure that blood flows only in one direction
Tricuspid valve – right atrium & right ventricle
Bicuspid valve – left atrium & left ventricle
Semi-lunar valve – at the base of aorta & pulmonary artery
The heart is made up of cardiac muscle which is myogenic (it contracts & relaxes automatically throughout life)

10. The rhythmic contractions are generated within the cardiac muscle itself & are not initiated by nerves.
The heart functions like two pumps with different pressure systems.
Right pump  deoxygenated blood  lungs
Left pump  oxygenated blood  body
Sinoatrial (SA) node (specialised cardiac muscle cell) located in the right atrial wall, near the entrance of the superior vena cava.
Function like a pacemaker  causing the atria to contract simultaneously  force blood into ventricles

11. Atrioventricular (AV) node (lying at the base of the right atrium)
The excitatory waves stimulate the AV node  generates its own electrical impulses which are conducted by specialised muscle fibres called bundle of His fibres & Purkinje fibres to the walls of ventricles  contract simultaneously & blood is pumped out of the heart.
Right ventricles which is less muscular pumps the blood into the pulmonary artery  lungs

12. Left ventricle is thicker & more muscular than the right ventricles  generate a greater pressure to pump blood through aorta & to other arteries in the body.

15. How does the blood in the veins flow back to the heart?
Normal movement  contraction of skeletal muscles squeezes the veins, increased pressure pushes open the valves in the veins to force the flow of blood towards the heart.
The valves in the veins prevent back flow of the blood
The residual heart pressure
Inhalation  the inspiratory movements lower the thoracic pressure & helps to draw the blood along the main veins towards the heart.
Gravity helps to return blood in those veins above the heart.

16. contraction of
skeletal muscle
around veins

17. FACTORS MODIFYING THE HEART RATE
SA node can initiate heartbeat on its own. The heart rate may be modified by certain other factors.
(a) the sympathetic nerve carrying impulses to the heart can increase the heart rate
(b) the parasympathetic nerve carrying impulses to the heart slows down the heart rate.

18. When excited  an increased secretion of the hormone epinephrine which causes the heart to beat faster
(a) an increase in the partial pressure of CO2 in the blood or a decrease in pH increase the heart rate
(b) a fall in partial pressure of CO2 in blood decreases the heart rate.

19. Heart rate also increase when body temperature is when there is a decrease in blood pressure

20. Regulatory Mechanism of blood pressure
Blood pressure – the force of the blood exerted by the pumping heart on the walls of the arterial blood vessels.
Arterial blood pressure is highest during contraction of the ventricles (ventricular systole) & lowest during diastole.
Normal human blood pressure – 120/80 mm Hg
Can be measured by using a sphygmomanometer
Blood pressure is regulated by a negative feedback mechanism.

22. Stretch-sensitive baroreceptors – located in the arch walls of the aorta & carotid arteries (supply blood to the brain).
Monitor the pressure of blood flowing to the brain & to the body.
An increase in blood pressure stretches the baroreceptors  impulses are sent to the cardiovascular centre in medulla oblongata to help regulate blood pressure.
Impulses sent via parasymphatetic nerve to the heart  slow down the heartbeat  smooth muscles of arteries relax, decrease the resistance of blood flow in the blood vessels  blood pressure decrease

23. The widening of blood vessels = vasodilation
The weaker cardiac muscle contraction & lower resistance of blood flow in blood vessels  blood pressure , back to normal value
If blood pressure low (in a state of shock)  baroreceptors less stimulated  send nerve impulses at a slower rate to the cardiovascular centre  stimulation of SA node by the sympathetic nerve  stronger cardiac muscle contraction as well as the smooth muscles in the walls of arteries  increase the resistance of blood flow in the blood vessels.
Narrowing of blood vessel  vasoconstriction

24. CIRCULATORY SYSTEM IN FISH, AMPHIBIANS & HUMANS

25. CIRCULATORY IN HUMANS, FISH &HIBIANS
CIRCULATORY SYSTEM IN FISH
Single circulatory system – blood flows through the heart only once for each circulation.
Heart  Deoxygenated blood  gills oxygenated blood  body  heart
Blood pressure drops  collected in sinuses (large spaces)  atrium

27. CIRCULATORY SYSTEM IN HUMANS
Double circulatory system – blood flows through the heart only twice for each circulation.
The pulmonary circulation & systemic circulation.
Pulmonary circulation – right ventricle  deoxygenated blood  lungs (via pulmonary arteries)  pulmonary veins  left atrium

28. CIRCULATORY SYSTEM IN HUMANS
Systemic circulation – left ventricle  oxygenated blood  body (via aorta)  superior & inferior vena cava  right atrium.
Complete double circulatory system  heart being divided into two  right pump (to lungs) & left pump (to body parts).
Advantages : oxygenated blood returns to heart to be pumped again  increases the pressure of the blood  speeding up the delivery.

29. CIRCULATORY SYSTEM IN AMPHIBIANS
Double circulatory system – blood flows through the heart only twice for each circulation.
The pulmonary circulation & systemic circulation.
Three-chambered heart  two atria & one ventricle.
Some mixing of oxygenated & deoxygenated blood in ventricle  enter the systemic circulation (incomplete double circulatory system)  less efficient.

31. CIRCULATORY SYSTEMS ORGANISMS CIRCULATORY SYSTEM CHARACTERISTICS
HUMANS
COMPLETE DOUBLE CLOSED CIRCULATORY SYSTEM
The blood enters the heart twice during one complete cycle.
The oxygenated & deoxygenated blood not mixing together
FISH
SINGLE CLOSED CIRCULATORY SYSTEM
An atrium & a ventricle
The deoxygenated blood enters the atrium & then the ventricle
The blood enters the heart once
AMPHIBIANS
INCOMPLETE DOUBLE CLOSED CIRCULATORY SYSTEM
Two atria, one ventricle
Mixing of oxygenated blood & deoxygenated blood in the single ventricle.
INSECTS
OPENED CIRCULATORY SYSTEM
Blood flow in haemocoel

32. TEST YOURSELF
WITH
WAJA 1.3

33. EXERCISE 1.2
The walls of the left side of the heart are generally thicker than those of the right side of the heart, and the wall of the ventricles are thicker than those of the atria. Suggest reasons for these differences.
Describe the similarities and differences between the arteries and veins.