1. Research Team of Elucidating Pathophysiology & Discovering Targets in Metabolic Disorders

2. Anti-inflammatory effects of PPAR gamma agonist Role of Foxc2 & Snail in steoporosis, Obesity, & bnormal Glucose Metabolism Genetic Risk of Posttransplantation Diabetes Mellitus Role of Parathyroid hormone in bone formation Prevention & Treatment for Diabetes & its complications Regeneration of Thyroid using Ad- AAV hybrid Vector To Elucidate pathophysiology and To discover Drug Target in Metabolic Disorders

3. Endocrine Research DIABETES BONE METABOLISM THYROIDPITUITARY

4. ○ Vision And Objectives VISION Elucidate the Pathophysiology of Metabolic Disorder and Discover the Molecular Targets of Metabolic Disorders

5. ○ Vision And Objectives 1. To Prevent & Treat Diabetes & its complications 2. To discover Anti-inflammatory effects of PPAR gamma agonist 3. To elucidate Role of Foxc2 & Snail as a treatment target in Osteoporosis, Obesity, & Abnormal Glucose Metabolism 4. To Find a Role of Parathyroid hormone in bone formation 5. To Develop Regeneration Therapy of Thyroid using Ad-AAV hybrid Vector 6. Research on Genetic Risk of Posttransplantation Diabetes Mellitus OBJECTIVES

6. ○ Organization and Participants Institute of Endocrine Research, Diabetes Center, Division of Endocrinology & Metabolism, Yonsei University College of Medicine Lee, Hyun Chul: Diabetes, Drug Development Lim, Sung Kil: Bone Metabolism, Obesity Lee, Eun Jig: Thyroid, Pituitary, Gene Therapy Cha, Bong Soo: Diabetes, PPAR gamma Kang, Eun Seok: Diabetes, Genetic Epidemiology Rhee, Yumie: Bone Metabolism

7. ○ Research Fields 1. To Prevent & Treat Diabetes & its complications 2. To discover Anti-inflammatory effects of PPAR gamma agonist 3. To elucidate Role of Foxc2 & Snail as a treatment target in Osteoporosis, Obesity, & Abnormal Glucose Metabolism 4. To Find a Role of Parathyroid hormone in bone formation 5. To Develop Regeneration Therapy of Thyroid using Ad-AAV hybrid Vector 6. Research on Genetic Risk of Posttransplantation Diabetes Mellitus

8. ○ Contact Point Director: Sung Kil Lim Address: Yonsei University College of Medicine, Department of Internal Medicine, 134 Shinchon Seodaemun, Seoul, Korea 120-752 Tel: 82-2-2228-1948 E-mail: LSK@yuhs.ac Website : http://sev.iseverance.com/class_main.asp?cat_no=1805