1. ONCODEATH Sensitization and resistant determinants of cancer cells to death receptor related therapies Contract No: LSHC-CT-2006-037278 Kick off meeting Athens, 1 December 2006

2. Contract Details (1) Specific Targeted Research Projects Specific Targeted Research Projects Started date: 1 st November 2006 Started date: 1 st November 2006 Duration: 36 months Duration: 36 months Community financial contribution: 2,344,900.00€ Community financial contribution: 2,344,900.00€

3. Contract Details (2) Reporting periods: Reporting periods: P1: From month 1 to month 12 P1: From month 1 to month 12 P2: From month 13 to month 24 P2: From month 13 to month 24 P3: From month 25 to the last month of the project P3: From month 25 to the last month of the project Reports submission: Reports submission: P1 – period P1 & P3 – periods P2 + P3 P1 – period P1 & P3 – periods P2 + P3 Within 45 days from the end of the reporting periods Within 45 days from the end of the reporting periods

4. Contract Details (3) Community financial contribution: Community financial contribution: Paid to the coordinator on behalf of the contractors – Distributed as soon as possible Payments: Payments: Pre-financing: 938,108.00€ - within 45 days from the entry into force of the contract Pre-financing: 938,108.00€ - within 45 days from the entry into force of the contract Intermediate payments: Intermediate payments: With an audit certificate: With an audit certificate: Payment to settle the amounts justified and accepted Payment to settle the amounts justified and accepted Intermediate pre-financing of 80% to the subsequent period and the next 6 months Intermediate pre-financing of 80% to the subsequent period and the next 6 months Without an audit certificate: Without an audit certificate: Intermediate pre-financing of 80% to the subsequent period and the next 6 months Intermediate pre-financing of 80% to the subsequent period and the next 6 months within 45 days from the approval by the Commission of the reports – necessary not less than 70% of a pre- financing has been used

5. Amendments Necessary the identification of the nature and the details of the request Necessary the identification of the nature and the details of the request Submitted in writing only by the coordinator on behalf of the consortium Submitted in writing only by the coordinator on behalf of the consortium Approval or rejection between 45 days of its receipts Approval or rejection between 45 days of its receipts

6. Overall budget

7. Consortium Agreement Based on Model Consortium Agreement provided by relevant working-group of the EU Based on Model Consortium Agreement provided by relevant working-group of the EU Main Subjects covered: Main Subjects covered: Organizational and Management Structure Organizational and Management Structure Party’s responsibilities and authority Party’s responsibilities and authority Confidentiality Confidentiality Liabilities Liabilities Intellectual Property Rights Intellectual Property Rights Distributed for comments

8. Obligations Forms A & A4 – signed and send until the end of December Forms A & A4 – signed and send until the end of December Pre-financing paid until 15 of December 2006 (?) and distributed ASAP Pre-financing paid until 15 of December 2006 (?) and distributed ASAP Consortium Agreement signed and send until the end of December Consortium Agreement signed and send until the end of December Launching of project’s Web Site until …… Launching of project’s Web Site until ……