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Cancer Historically agents given systemically – Agents that kill rapidly dividing cells Find therapeutic dose  Kills tumor cells w/o killing patient –

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Presentation on theme: "Cancer Historically agents given systemically – Agents that kill rapidly dividing cells Find therapeutic dose  Kills tumor cells w/o killing patient –"— Presentation transcript:

1 Cancer Historically agents given systemically – Agents that kill rapidly dividing cells Find therapeutic dose  Kills tumor cells w/o killing patient – Lots of side effects Localized/targeted delivery is the holy grail – Nanomedicine!! – Also protection from degradation and increased solubility

2

3 Nanoparticles – drug throughout Nanocapsules – drug w/in coating PEGylation – makes stealthy Ligand – binds to cell receptor for targeting

4 Tumor Vasculature Irregularly shaped, big, and leaky Lack of lymph drainage High vessel density

5 Passive Targeting  EPR Small drugs enter tumor and leave Particles enter and stay – Long circulation time key

6 Active Targeting EPR + something that binds tumor cells specifically

7 Targeting  Interfere with signaling when bind (targeting ligand and drug)  Ab tethered to drug  Ligand + drug  depends upon over-expression of surface molecules by tumor cells

8 Paige

9 Daruwalla, Cancer Science, 2010; 101; 1866-1874 Paige

10 Daruwalla, Cancer Science, 2010; 101; 1866-1874 MoCR IC 50 =1.2  M MCF-7 IC 50 =0.8  M HT-29 IC 50 =0.85  M DLD-1 IC 50 =0.8  M Paige

11 Daruwalla, Cancer Science, 2010; 101; 1866-1874 Shrinidhi

12 Daruwalla, Cancer Science, 2010; 101; 1866-1874 Shrinidhi

13 Daruwalla, Cancer Science, 2010; 101; 1866-1874 Shrinidhi

14 Daruwalla, Cancer Science, 2010; 101; 1866-1874 Anna

15 Daruwalla, Cancer Science, 2010; 101; 1866-1874 Anna

16 Daruwalla, Cancer Science, 2010; 101; 1866-1874 Anna

17 Daruwalla, Cancer Science, 2010; 101; 1866-1874 Felix

18 Kevin

19 Lehtinen, PLOS One, 2012; 7(7); e41410- Kevin

20 Lehtinen, PLOS One, 2012; 7(7); e41410- Inseong

21 Lehtinen, PLOS One, 2012; 7(7); e41410- Inseong

22 Lehtinen, PLOS One, 2012; 7(7); e41410- Maura background non-targeted pre-targeted direct target

23 Lehtinen, PLOS One, 2012; 7(7); e41410 Maura

24 Lehtinen, PLOS One, 2012; 7(7); e41410- Michael

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