1. Revolutionizing Allergy Treatment Current Trend in the Treatment & Management of Allergic Rhinitis

2. 2 Allergy Suffers in Canada

3. 3 Relative Prevalence of Allergen (%) Sources: identified in allergic patients

4. 4 Seasonal or Perennial Allergies Allergies in America Exe. Summary; Aug. 23, 2007.

5. 5 Allergic rhinitis is one of the most common diseases About ten million Canadians suffer from seasonal allergies or seasonal allergic rhinitis Fall is the worst time of the year. Shorter days and longer nights that start in mid-August stimulate pollination in the ragweed plant Seasonal and perennial rhinitis affects 4 to 40% of the population and is increasing Prevalence in 16-year-old children rose from 12 % to 23 % from 1958 to 1970 Allergic Rhinitis Affects many Canadian Adults and Children

6. 6 Quality Of Life More than 62 percent of sufferers say allergies significantly impact their day-to-day lives, including affecting sleep patterns and ability to perform at work. Residents of Manitoba / Saskatchewan are affected the most (69%), followed by Ontarians (66%), then Quebecers (60%).

7. 7 Males Vs Female Females are impacted more severely %

8. Allergy Season in Canada ProvinceJanFebMarAprilMayJuneJulyAugSept.OctNovDec BC Prairies Ontario Quebec Atlantic All Prov. Molds Animal dander/ saliva House Dust Mite Cockroach Grass Tree Ragweed Weed

9. 9 Visit to the Health Care Practitioners N = 2500 Allergies in America Exe. Summary; Aug. 23, 2007. Allergy Sufferers %

10. 10 AR a Major Contributor to Health related Absenteeism Mean Annual Productivity Loss ($) Per Employee *P<0.05 for Allergic rhinitis /hay fever vs. other conditions. Lamb CE, et al. Curr Med Res Opin. 2006; 22:1203-1210.

11. 11 AR Imposes a Significant Burden on Quality of Life AR is Associated With: Fatigue and daytime sleepiness Daily activity impairment Reduced work productivity Impaired cognitive functioning Reduced learning abilities Impaired sleep Impaired quality of life Marshall PS, et al. Psychosom Med. 2002;64:684-69; Stuck BA, et al. J Allergy Clin Immunol.2004;113:663-668; ousquet J, et al. J Allergy Clin Immunol. 2006;117:158-162; Tanner LA, et al.Am J Manag Care. 1999;5(suppl 4):S235-S247; Blanc PD, et al. J Clin Epidemiol. 2001;54:610-618; Wilken JA, et al. Ann allergy Asthma Immunol. 2002;89:372-380; Marshal PS, et al. Ann Allergy Asthma Immunol. 2000;84:403-410; Vuurman EFPM, et al. Ann Alllergy. 1993;71:121-126;Leger D, et al. Arch Intern Med. 2006;166:1744-1748.

12. 12 Use of OTC Medications AR Sufferers Who Used Medications in Past 4 Weeks Allergies in America Exe. Summary; Aug. 31, 2007. %

13. 13 Impact of Family History on Diagnosis of AR No Family History One Parent With AR Both Parents With AR 57/334 (17.1%) 11/21 (52.4%) 31/120 (25.8%) Total, N = 816 No Allergic diseases, n=449 (some children had more than one allergic disease) Rhinitis, n = 99 Gerrard JW, et al. Ann Allergy. 1976;36:10-15.