1. Current Areas of Space-Related Health Research Role of oxidative stress in –Cancer –Cataracts Bone loss –Vitamin D, calcium, vitamin K –Non weight-bearing exercise to sustain bone health Melatonin and sleep cycle regulation Presenter: Paul M. Coates Agency/Organization: NIH Office of Dietary Supplements

2. Promising Areas for Space-Related Health Research Collaborations Dose-response studies of vitamin D and calcium in maintaining bone health Mechanisms to protect against free radical damage to lens proteins

3. Existing Resources to Facilitate Space-Related Health Research NIH Botanical Research Centers Program –Purdue University-University of Alabama at Birmingham Project: Polyphenols, singlet oxygen and protein damage in the eye (Stephen Barnes, Ph.D. and Om Srivastava, Ph.D.)

4. The ICR/f rat - model for lens cataracts Sprague-Dawley Rat ICR/f Rat A colony of ICR/f rats has been established at UAB

5. Lens cataracts in ICR/f rats Nuclear, mature Cortical, early Cortical, mature