1. Lymphatic System

2. Functions of the Lymphatic System 1.Return interstitial fluid to bloodstream 2.Transport lipids and lipid-soluble vitamins in the bloodstream 3.Production and maturation of lymphocytes 4.Generates an immune response against antigens in interstitial fluid

3. Lymphatic System

4. Lymph Lymph is fluid in lymphatic vessels Comprised of: Interstitial fluid Solutes Foreign materials

5. Lymphatic Capillaries Closed-ended tubes; among blood capillary beds GI tract contains specialized lymph capillaries called lacteals –collect lipids and lipid-soluble vitamins

6. Lymphatic Vessels Lymphatic capillaries merge to form lymphatic vessels –Resemble venules Possess valves similar to veins Afferent lymphatic vessels  into lymph node Efferent lymphatic vessels  away from lymph node Lymphatic vessels merge  lymphatic trunks

7. Lymphatic Trunks

8. Lymphatic Ducts Lymphatic trunks  Lymphatic ducts Right lymphatic duct - –Returns lymph from right side of head/neck, upper limb and thorax Thoracic duct - largest lymphatic vessel –collects lymph from rest of body

9. Lymphatic Cells Macrophages –Monocytes that have migrated –Phagocytize foreign substances Nurse cells –Secrete hormones in thymus Dendritic cells –In lymph nodules –Antigen-presenting cells Lymphocytes

10. Types of Lymphocytes Three types of lymphocytes: 1.T-lymphocytes (T-cells) 2.B-lymphocytes (B-cells) 3.NK cells

11. T-Lymphocytes 70-85% of lymphocytes Can recognize a particular antigen Main types:  Helper T-lymphocytes  Cytotoxic T-lymphocytes  Memory T-lymphocytes

12. Helper T-Lymphocytes Also called CD4 or T4 cells Many types, each responds to a different antigen T4 cells initiate and oversee the immune response 1.Present antigen to other lymphocytes 2.Secrete cytokines - hormones that activate other lymphatic cells HIV infects these cells –Shuts down immune response

13. Cytotoxic T-Lymphocytes Also called CD8 or T8 cells Come in direct contact w/infected or foreign cells and kill them Must be activated by helper T-cell that presents an antigen to it

14. Immune Response of T-Lymphocytes

15. Memory T-Lymphocytes Arise from T cells that have encountered antigen Mount faster response than initial exposure

16. B-Lymphocytes 15-30% of body lymphocytes Produce immunoglobins (Ig), or antibodies, to a single antigen Become activated when presented with antigen from helper T- cell –Undergo division to two cell types: Most become plasma cells – produce antibodies –Live less than a week Some become memory B cells –Live weeks to years –Confer lifetime immunity

17. B-Lymphocytes and Their Role in the Immune Response

18. NK (Natural Killer) Cells Small percentage of all lymphocytes Can kill a wide variety of infected cells and some cancerous cells

19. Lymphatic Organs Tonsils – trap antigens Thymus – T cell maturation Lymph nodes – filter antigens from lymph Spleen

20. 1.Initiates immune response when antigens found in blood 2.Reservoir for erythrocytes and platelets 3.Phagocytizes old, defective erythrocytes and platelets 4.Phagocytizes bacteria and other foreign materials