1. CNS Therapy, AG SET (Systolic Extinction Training) We are the defibrillator for chronic pain.

2. CNS Therapy, AG SET (Systolic Extinction Training) We are the defibrillator for chronic pain.

3. Problem Chronic pain is pain that lasts longer than six months. It can be mild or excruciating, episodic or continuous, inconvenient or totally incapacitating. Fibromyalgia, Migraine, Lower Back Pain, TMD, … Over 100 million Americans suffer from chronic pain, a huge potential market. An unpleasant sensory and emotional experience 1/31/15CNS Therapy, AG Confidential

4. Solution - SET A new non-invasive and low risk medical device Cardiac gated electrical stimulation to the hand. Disrupts pain patterns and encourages learning. combined with Behavioral Operant Therapy and E-learning Changes patient and partner pain adaptations, behaviors, cognitions, rewards, and movement, 5 weeks, 20 hours, highly successful 1/31/15CNS Therapy, AG Confidential

5. How it works simplified Pain is perception. With chronic pain, the brain has learned not to inhibit peripheral inputs and the person is constantly or intermittently in a state of pain. This brain pattern has been adopted and is maintained due to stress, psychology, and other factors. We discovered that these patterns are associated with measurable weakness in the autonomic nervous system (ANS). Our device is able to use the ANS to disrupt these patterns and renew itself through 8 minute cardiac gated electrical stimuli. When the pattern is upset, the brain is more receptive to learning. We use this opportunity, through operant conditioning and behavioral training, to correct the behaviors, cognitions adaptations, and reward structures that maintain the pain. The use of the device and therapy is individualized and guided by a patient and therapist E-learning program that tracks results and insures standardization. It has a long term effect and can be refreshed if needed. Works for over ½ of the people. They cannot use medication or have personality disorders and must be willing to work to change behaviors. 1/31/15CNS Therapy, AG Confidential

6. Spin off From scientists Dr. Richard H. Gracely, Dr. Bill Maixner, and Ollie Monbureau at the University of North Carolina, USA and from the Lab of Professor Kati Thieme, Phd., head of the Department of Medical Psychology, University of Marburg, Germany. Patent Pending Presented at the IASP, Buenos Aires 1/31/15CNS Therapy, AG Confidential

7. Traction Patent filed Published Theory Licensed IP from UNC Miniaturized Device (1st cardiac gated stim device ever) Treated over 180 Patients with multiple therapists Proved acceptance from the Pain Community Prof. Thieme earned the German pain prize for 2012. Organized multicenter study Waiting for a regulatory approved device. 1/31/15CNS Therapy, AG Confidential

8. US Distribution Step 1. – 510K approved device Step 2. – Present to: 93,000 Psychologists 60,000 Chiropractors 200,000 Physical Therapists 4,000 Pain Specialists Per patient leasing model – low upfront cost for the provider. 1/31/15CNS Therapy, AG Confidential Fibromyalgia Syndrome The absence of proof is not the proof of absence. Leonardo Da Vinci Undertreated Americans in Pain 116 million (Institute of Medicine Report 2011)

9. Competition Medical Doctors, Implants, and Drugs – Low effect for chronic pain, side effects, fast/easy prescription, harmful over time, invasive, $$$$$, risky, increasing dosages, adaptation. Traditional Therapy – slow, often not effective, changing the mind without the body is difficult and expensive. TENS, bio- and neurofeedback, yoga, meditation, … - checker board results, short term effect, studies inconclusive. None use patient biological heterogeneity. 1/31/15CNS Therapy, AG Confidential

10. Testimonials My pain is completely gone. I am pain-free. I can sleep deeply and feel refreshed in the morning. The stiffness of my muscles is gone. I sense much more power than before. I feel so awake. My muscles are more flexible thus I can take stairs much easier than before and faster. I went back to work and am happy to fulfill the tasks like everybody else. My husband changed his behaviors: He helps me only when I have ask him to. We talk about our kids, friends, our jobs, and our wishes and interests. I run three times the week for 6 miles and do not have any pain anymore. I feel relaxed, see the natural beauty more intensely, and can laugh again. 1/31/15CNS Therapy, AG Confidential

11. More Info www.setmarburg.com Patent and posters www.setmarburg.com/iasp-2014 Scientific Papers and Theory www.setmarburg.com/paper Contact: Switzerland – klein@bluewin.ch Germany – kati.thieme@staff.uni-marburg.de USA – mmathys@gmail.com 1/31/15CNS Therapy, AG Confidential