1. Honors Biology Chapter 7 Beyond Mendelian Genetics

2. Many Human Phenotypes Follow Mendelian Pattern One gene / two alleles = 1 trait

3. Genetic Disorders Rare heritable illnesses Most lethal disorders are recessive

4. Cystic Fibrosis

5. Huntington’s Disease – Dominant

6. Some Deleterious Genes Are Sex-Linked X-linked Recessive – Hemophilia (Bleeders Disease)

7. Hemophilia

9. X-linked Dominant Retinitis Pigmentosa

10. Non-Mendelian Genetics Complex Patterns of Inheritence Traits do not segregate according to Mendel’s Laws – X inactivation – Incomplete Dominance – Codominance – Polygenic Traits Epistasis – Multiple Alleles – Environmental Influences – Others

11. X-Inactivation

13. Epistasis

14. Incomplete Dominance

15. Codominance

17. Multiple Alelles

18. Sex-linked Traits

21. Polygenic Traits

25. Gene Linkage

26. Karyotypes Prepared from blood, bone marrow, amniotic fluid, placenta

27. Karyotypes

28. Karyotypes Detect Abnormal #

29. Karyotypes Detect Structural Defects

30. Pedigrees