1. Parkinson’s patient & doctor aiding system Performed by: Alexander Kinko Stanislav Shapiro Barukh Trabelsi Instructor: Boaz Mizrachi Duration: 2 Semesters Characterization Presentation Part 1 - Winter 2009 Characterization Presentation Part 1 - Winter 2009

2. The Parkinson’s patient often suffers from involuntary seizures, that are unnoticeable to him, but tire his muscles and cause great pain. The appearance of the tremor is random. Muscles’ behaviour is very similar to that, as they were intensively used during some kind of hard work. Parkinson’s patient must have a periodic physiotherapeutic treatment, in order to relief the pain, caused by the cramped muscles. Patients can significantly improve quality of life, if were given some kind of an “alarm”, when the tremor starts. Consequently, the unwanted tremor can be stopped and the seizures of the muscles can be prevented. Introduction

3. Project’s Basic Concept PMD  PC Interface USER  PC Interface Parkinson’s Patient Portable Mobile Device PC

4. Table Of Contents Project’s Goals Project’s Overview (Semester A) Project’s Overview (Semester B) Technical Requirements Project’s Basic Block Diagram Suggested Parkinson’s Flow Detection Project’s Implementation Components’ Choice Estimated Timeline

5. Design a portable low-power system which: Identifies presence of tremor. Analyzes vibrations and detects a Parkinson’s tremor. Notifies the user about appearing of unwanted tremor (“alarm”). Enables better tracking of the disease by storing data, describing specific tremor’s appearance, like:  Starting time  Duration  Strength (amplitude)  Frequency Runs on a daily basis, powered by rechargeable battery, that is recharged by the solar cells or by connection to the external power source. Low battery indicator alerts user when battery is low. Project’s Goals

6. Project’s Goals (continuation) Designing PCB and appropriate packaging, resulting in a small low-power Portable Mobile Device (PMD), like an ordinary wrist watch. Creating a unique set of software for PC and PMD, which enables performing of the following tasks:  Downloading data from portable device.  Performing of the data processing on downloaded data and displaying the appropriate statistics on PC.  Creating database and storing it for the further inspection by the patient / doctor.

7. Project’s Overview (semester A) Stanislav and Barukh: Choosing components for the project, suitable for low-power applications. Designing a digital part of the project (schematics). Designing, manufacturing and assembling of the PCB for PMD. Performing basic debug. Alexander: Designing the power part of the project (solar cells, battery recharge and power managing). Designing and production of the appropriate packaging for PMD. Assisting to Stanislav and Barukh in the integration between power and digital part of the project and the items related to production of PCB.

8. Project’s Overview (semester B) Stanislav and Barukh: Debugging the hardware of the PMD device. Designing software for embedded hardware of the PMD that includes recognition of the unique nature of Parkinson’s tremor and storing the basic parameters on the PMD’s memory. Creating low-level drivers for basic interface to the PC Alexander: Assisting to Stanislav and Barukh in the debug of PMD. Designing a unique high-level software for PC, that enables communication with PMD, creating the database, performing various graphs and storing the database for further inspection by patient / doctor.

9. Technical Requirements Autonomous portable system worn on the Parkinson’s patient wrist. Recognition of a unique nature of Parkinson’s tremor (2÷10 Hz). Recognition of maximum 2 Parkinson’s attacks per minute. Storing of the parameters describing each Parkinson’s attack in the non-volatile on-device memory. Minimal period for storing the parameters - 7 days. Low-power rechargeable battery application. Alert for “low-battery” state. Notification to patient on appearing of Parkinson’s attack by:  Vibration (depends on vibration motor availability)  Buzzer / LED indication. Physical dimensions of the PMD are like ordinary wrist watch. Interconnection to PC for performing extended data processing and better tracking.

10. Project’s Basic Block Diagram IR Accelerometer Controller EEPROM Data Control Buzzer + LED Vibration Motor User Control User Interface Infrared Transceiver PC FIFO INT when FIFO is full USB Vibration Motor Control Buzzer+LED Control RTCC Memory Control Internal Memory Parkinson’s Detection Comm. Control Accelero- meter Control

11. YesNo Suggested Parkinson’s Flow Detection Start Sample Data Digital B.P.F. Parkinson’s Tremor ? Store Parkinson’s tremor parameters in the PMD’s memory

12. Project’s Implementation A Accelerometer ADXL 345 (3-Axis) (Analog Devices) PIC Controller PIC24FJ256GB106 (MicroChip) IRDA Transceiver TFBS6711 (Vishay) PC Power Manager BQ24032A (Texas Instruments) DC-DC TPS63000 (Texas Instruments) Rechargeable Battery LIR2450/2032 120/40 mAh (Dantona) Solar Cell 5V@5mA Buzzer F# 1192551 (Murata) 1-Mbit Serial EEPROM 25AA1024 (MicroChip) Infrared USB Push Buttons (Control) Portable Mobile Device (PMD) Vibration Motor LA3R5-448 (Copal-Nidec)

13. Accelerometer - ADXL345 (Analog Devices) Built-In FIFO - seldom wake up of PIC for analysis Very low power Low price Controller - PIC24FJ256GB106 (MicroChip) Low power modes Lots of data storage space Internal hardware implemented RTC (Real Time Clock) Components’ Choice

14. Serial EEPROM - 25AA1024 (MicroChip) 1 Mbit + SPI interface Very high reliability (1M erase/write cycles & data retention > 200 years) Low price & very small package Vibration motor - LA3R5-448 (Nidec-Copal) Low price Very small Buzzer - PKLCS1212E4001-R1 (Murata) Low price and very small (12x12x3 mm)

15. Power manager chip - BQ24032A (TI) Suitable for Li-Ion Battery Two sources of external power: USB + solar cell Low price DC-DC converter- TPS63000 (TI) High efficiency (96%) Low price Solar cell - (Alternative/Emcore (?)) Excellent power/size ratio Rechargeable battery - LIR 2450/2032 (Dantona) Capacity of: 120/40 mAh Small Size (button-cell) & low price

16. Estimated Timeline

17. Any Questions...?