1. Lab#5 Preparation of effervescent granules Presentation to students of health college Monday, April 04, 2010 by: TA/ Mohammad Al- Mermesh, BSc., PGC,

2. 1.Prepare 20 gm of effervescent base sodium Bicarbonate 53 % citric acid 19 % tartaric acid 28 % Calculations: Prepare 25 gm & 5 gm extra …. Base alone Sodium bicarbonate = 25 x 53/100 = 13.25 gm Citric acid = 25 x 19/100 = 4.75 gm Tartaric acid = 25 x 28/100 = 7 gm Alcohol = 25 x 15 ml/100 = 3.75 ml

3. Prepare 20 gm of effervescent granules containing 10 % Iron Ammonium citrate Calculations: Base + drug Drug = 25 x 10/100 = 2.5 gm Wight of the base = 25 – 2.5 = 22.5 gm Wight of sodium bicarbonate = 22.5 x 53/100 = 11.9 gm Wight of citric acid = 22.5 – 19/100 = 4.3 gm Wight of tataric acid = 22.5 x 28/100 = 6.3

4. Procedure: 1.Weigh the required amount of all ingredients (sod., citric, tartaric), grind the powder in mortar to finely ground powder then pass through sieve no. 60 2. Mix all ingredient powders homogenously in a porcelain mortar, then add wetting agent (alcohol 95 %) to form coherent mass 3.The coherent mass passed through sieve no 12, by pressing in one direction 4. the collected granules are dried in a hot oven of 40° C for 10 5. Pack the final product I a specific container

5. Uses: Iron deficiency anemia Role of each ingredients: Iron: Active Ingredient Citric Tartaric Sod. Alcohol: Moistening Agent } Base

6. Thank You