1. James Anderson, M.D., Ph.D. Director Division of Program Coordination, Planning, and Strategic Initiatives October 27, 2011 The NIH Common Fund

2. Common Fund Programs FY2011 HRHR Molecular Libraries IR CTSAs HMP Epigenomics

3. ■ Enabling Infrastructure ■ Rapid Access to Intervention Development (RAID) ■ Molecular Libraries and Imaging Common Fund programs catalyze research across a broad spectrum of diseases/conditions ■ New Tools, Technologies, Data ■ Library of Integrated Networks of Cellular Signatures (LINCS) ■ Human Microbiome Project

4. LINCS is providing comprehensive data on the global response of signaling networks to perturbagens. Perturbagens Phenotypic assays Cell types Data generation, analysis, integration Functional annotation with existing knowledge

5. 1. Is the program truly transforming – could it dramatically affect how biomedical research is conducted within a predictable timeframe? Questions for LINCS to consider in planning for its second phase: 2. Can the transformative outcome be accomplished or milestones reached within the 5-10 yr period of funding from the Common Fund? 3. Will the outcomes synergistically promote and advance the individual missions of NIH ICs to promote health? CF programs should enable, strengthen, and promote IC-funded research. 4. Is the program sufficiently complex that it requires coordination of the efforts of multiple ICs? Is the initiative not easily assignable to the mission of a single IC? 5. Is the proposed initiative something that no other entity is likely or able to do? If other entities are also engaged, what is the gap that the CF will fill? How will related activities be coordinated?