1. MacLennan Selected Risks and Benefits after 5 Years of combined estrogen and progestogen HRT for all women aged 50-79 (WHI Study, 2002) OESTROGEN WITH PROGESTOGEN Breast Cancers 8 Pulmonary Embolism 8 Bowel and Uterine Cancers 10 Fractures Hip and Spine 10,000 Women Years Increase Decrease Stroke 8 CVD* 7 * Not statistically significant

2. MacLennan Selected Risks and Benefits after 7 Years of estrogen only HRT for all women aged 50-79 (WHI Study, 2004) OESTROGEN ONLY 8 Breast Cancers* Pulmonary embolism* 3 5 CVD* 12 Fractures Hip and Spine 10,000 Women Years Increase Decrease Stroke 12 * Not statistically significant Bowel Cancer* 1

3. MacLennan Combined Estrogen + Progestogen HRT outcomes when initiated under age 60. (Data from 5,522 women in WHI Study) Breast Cancer 2 Pulmonary Embolism 1 Stroke 4 10,000 Women Years Increase Decrease CVD 7 Deaths 13 Diabetes 56 All Fractures 59........ ESTROGEN AND PROGESTOGEN

4. MacLennan Estrogen only HRT outcomes when initiated under age 60 (Data from 3,310 women in WHI Study) 8 Breast Cancer Pulmonary Embolism 1 2 Stroke 56 All Fractures 10,000 Women Years Increase Decrease 11 CVD 3 Total Deaths 59........ 22 Diabetes 22........ ESTROGEN ONLY