1. DNA Structure/Function

2. RECALL … 4 classes of macromolecules –Carbohydrates –Lipids –Proteins –NUCLEIC ACIDS!!! –Subunit: NUCLEOTIDES

3. Nucleic Acid Examples DNA – deoxyriboNUCLEIC ACID (de – without, oxy – oxygen, ribo – ribose sugar) Store and pass genetic information Code for proteins RNA – riboNUCLEIC ACID Protein synthesis Subunits of DNA/RNA: nucleotides

4. DNA Very longVery long thin molecule made up of linked nucleotides Double stranded helix –Twisted ladder Determines traits of EVERY LIVING ORGANISM

5. Nucleotide Structure 3 parts –Sugar (deoxyribose or ribose) –Phosphate (P with oxygens attached) –Nitrogen base Adenine Thymine Guanine Cytosine

6. Nucleotide Structure 2 classes of nucleotides –Purines Adenine Guanine –Pyrimidines Thymine Cytosine Purines are PURE – like A n G els P y rimidines – Y like Th y mine and C y tosine

7. Nitrogen Base Pairing Adenine Thymine 4-eva Guanine Cytosine

8. Nitrogen Base Pairing Adenine Thymine Guanine Cytosine = Hydrogen Bond

9. Nitrogen Base Pairing Adenine Thymine CytosineGuanine ThymineAdenine CytosineGuanine AdenineThymine Guanine Cytosine = Hydrogen Bond

10. Nitrogen Base Pairing Adenine Thymine CytosineGuanine ThymineAdenine CytosineGuanine AdenineThymine Guanine Cytosine Sugar + Phosphate backbone

12. Compl-e-ment – complement –To complete, finish, or fill something up NOT this kind… Compl-i-ment - compliment –“My students are the best in the school!”

13. What is the COMPLEMENTARY DNA STRAND? EXAMPLE 1 3’ end 5’ end ATTGACCATTGATAGCCGAATA TAACTGGTAACTATCGGCTTAT EXAMPLE 2 5’ end 3’ end TCTTCGGAACATTAGTCGAGGC AGAAGCCTTGTAATCAGCTCCG

14. Now you try! Find the complementary DNA strand! 1.TAG ACC CAG CCC 2.CCG CAC CTG TTA AAA