1. Alcohol and Ovarian Cancer Publication Genkinger, JM, et al.. Br J Cancer 2006 Mar 13;94(5):757-62. Genkinger, JM, et al. Alcohol intake and ovarian cancer risk: A pooled analysis of ten cohort studies. Br J Cancer 2006 Mar 13;94(5):757-62.

2. Genkinger et al, 2006 Swedish Mammography Cohort (SMC) Netherlands Cohort Study (NLCS) New York State Cohort (NYSC) Iowa Women’s Health Study (IWHS) Canadian National Breast Screening Study (CNBSS) Cohort studies in the pooled analysis of alcohol intake and ovarian cancer Cancer Prevention Study II Nutrition Cohort (CPS II) Breast Cancer Detection Demonstration Project Follow-up Study (BCDDP) Total cohort size= 529,638 Total # of cases = 2,001 Nurses’ Health Study (NHSa, NHSb), Nurses’ Health Study II (NHS II), Women’s Health Study (WHS)

3. Genkinger et al, 2006 Cohort studies in the pooled analysis of alcohol intake and ovarian cancer Study Follow-upYearsBaselineCohort#Cases Baseline Age Range, years BCDDP1987-199932,88514240-93 CNBSS1980-200049,61322340-59 CPS II 1992-200161,20227850-74 IWHS1986-200128,48620855-69 NLCS1986-199562,41220855-69 NYSC1980-198722,5507750-93 NHSa1980-198680,19512034-59 NHSb1986-200259,53831540-65 NHS II 1991-200091,5025227-44 SMC1987-200461,10328540-74 WHS1993-200432,46610445-89

4. Genkinger et al, 2006 Median Intakes (Interquartile Range) of Alcohol Among Drinkers by Cohort Study Median Intake(g/day) Among Drinkers CohortPercent of Drinkers Total Alcohol Intake Alcohol Intake from Wine Alcohol Intake from Beer Alcohol Intake from Spirits from Spirits BCDDP52 3.1 (0.9-10.4) 1.4 (0.4-4.6) 0.9 (0.3-1.9) 2.2 (0.5-6.5) CNBSS77 6.6 (2.4-14.9) 3.1 (1.0-7.1) 1.7 (0.9-3.7) 2.3 (1.1-6.8) CPS II 53 4.3 (1.1-11.3) 1.4 (0.7-5.8) 0.9 (0.9-2.8) 2.1 (1.0-11.0) IWHS45 3.6 (1.7-11.2) 1.7 (0.9-3.0) 1.8 (1.1-5.7) 2.1 (1.2-6.5) NLCS68 4.1 (1.4-12.0) 3.2 (1.2-9.6) 1.1 (0.5-2.8) 4.6 (1.1-12.1) NYSC78 1.9 (0.5-9.5) --------- NHS(a)68 5.5 (1.8-12.1) 1.5 (0.9-4.7) 1.8 (1.0-5.5) 2.0 (1.1-6.0) NHS(b)65 5.0 (1.9-12.4) 1.8 (0.9-5.6) 1.8 (1.0-5.5) 2.0 (1.1-6.0) NHS II 57 2.8 (1.5-6.6) 1.5 (0.9-3.0) 2.0 (1.1-4.9) 1.2 (1.2-2.1) SMC67 2.8 (1.5-4.6) 1.8 (1.6-3.3) 0.9 (0.4-1.8) 1.0 (0.9-1.0) WHS60 3.8 (1.8-10.2) 1.7 (0.9-5.5) 1.8 (0.9-3.4) 2.1 (1.2-6.5)

5. Genkinger et al, 2006 Study-Specific and Pooled Multivariate Adjusted RR and 95% CI for Ovarian Cancer According to Intake of Total Alcohol Study Categories of Alcohol Intake (g/day) 01-4.95-14.915-29.9 >30 BCDDP 1.00 (Ref) 1.25 (0.84-1.87) 1.39 (0.82-2.35) 1.70 (0.87-3.33) 2.21 (0.92-5.31) CNBSS 1.00 (Ref) 0.90 (0.61-1.33) 1.21 (0.81-1.80) 1.10 (0.67-1.81) 1.27 (0.71-2.25) CPS II 1.00 (Ref) 1.07 (0.81-1.41) 0.85 (0.59-1.22) 0.82 (0.43-1.53) 0.79 (0.39-1.58) IWHS 1.00 (Ref) 1.28 (0.94-1.75) 0.87 (0.53-1.41) 0.71 (0.31-1.64) 0.75 (0.30-1.88) NLCS 1.00 (Ref) 1.06 (0.73-1.52) 1.07 (0.67-1.70) 0.77 (0.39-1.53) 1.79 (0.83-3.85) NYSC 1.00 (Ref) 0.98 (0.58-1.65) 0.28 (0.08-0.96) 0.41 (0.09-1.81) 0.53 (0.07-4.02) NHSa 1.00 (Ref) 0.90 (0.58-1.40) 0.82 (0.49-1.36) 0.92 (0.44-1.91) 0.78 (0.32-1.87) NHSb 1.00 (Ref) 1.13 (0.86-1.50) 0.85 (0.60-1.20) 1.52 (1.01-2.29) 0.87 (0.49-1.56) NHS II 1.00 (Ref) 0.94 (0.52-1.72) 0.73 (0.29-1.83) 0.60 (0.08-4.50) 1.59 (0.21-12.1) SMC 1.00 (Ref) 1.04 (0.80-1.35) 1.04 (0.68-1.59) 1.19 (0.29-4.85) --- WHS 1.00 (Ref) 0.78 (0.48-1.27) 1.10 (0.65-1.87) 1.04 (0.43-2.49) 1.66 (0.64-4.32) Cases75472932012276 Pooled 1.00 (Ref) 1.06 (0.95-1.18) 0.96 (0.84-1.11) 1.09 (0.89-1.35) 1.12 (0.86-1.44)

6. Genkinger et al, 2006 Pooled Age and Multivariate Adjusted RR and 95% CI for Ovarian Cancer According to Intake of Alcohol from Specific Beverages Categories of Alcohol Intake (g/day) WineRange01-4.95-14.9 >15 Cases96571917466 Age RR 1.00 (Ref) 1.04 (0.94-1.15) 1.05 (0.89-1.25) 1.21 (0.92-1.60) MV RR 1.00 (Ref) 1.03 (0.93-1.14) 1.03 (0.86-1.23) 1.18 (0.89-1.57) Beer Cases14623964818 Age RR 1.00 (Ref) 1.11 (0.98-1.25) 0.76 (0.57-1.02) 1.40 (0.87-2.25) MV RR 1.00 (Ref) 1.09 (0.97-1.24) 0.75 (0.56-1.01) 1.38 (0.85-2.25) Spirits Cases133538013970 Age RR 1.00 (Ref) 1.01 (0.89-1.15) 1.03 (0.78-1.37) 1.17 (0.85-1.61) MV RR 1.00 (Ref) 1.01 (0.89-1.15) 1.02 (0.75-1.38) 1.16 (0.85-1.57)

7. Genkinger et al, 2006 Pooled Multivariate RR and 95% CI for a 15g/day Increment in Total Alcohol Intake by Levels of Hormonal/Reproductive Ovarian Cancer Risk Factors, Continuous Model FactorCases Relative Risk (95% CI) P-value, test for Interaction Hormonal/Reproductive Parity (live birth) Parity (live birth) < 1< 1< 1< 1518 1.02 (0.88-1.20) > 1 1435 1.02 (0.94-1.12) >0.99 Oral Contraceptive Use Oral Contraceptive Use Never1124 1.02 (0.88-1.18) Ever599 1.05 (0.96-1.16) 0.41 Hormone Replacement Therapy Hormone Replacement Therapy Never634 1.02 (0.84-1.23) Past239 1.19 (0.99-1.44) Current211 1.10 (0.90-1.35) 0.39 Menopausal Status at Diagnosis Menopausal Status at Diagnosis Premenopausal140 0.72 (0.39-1.32) Postmenopausal1301 1.05 (0.94-1.16) 0.24

8. Genkinger et al, 2006 Pooled Multivariate RR and 95% CI for a 15g/day Increment in Total Alcohol Intake by Levels of Nutritional Factors, Continuous Model FactorCases Relative Risk (95% CI) P-value, test for Interaction Nutritional Methionine Intake (Median) Methionine Intake (Median) Low990 1.02 (0.94-1.12) High1011 1.04 (0.85-1.26) 0.34 Folate Intake (Median) Folate Intake (Median) Low743 0.97 (0.86-1.09) High748 1.05 (0.89-1.24) 0.18 Multivitamin Use Multivitamin Use No959 1.01 (0.90-1.13) Yes513 1.01 (0.83-1.23) 0.56

9. Genkinger et al, 2006 Pooled Multivariate RR and 95% CI for a 15g/day Increment in Total Alcohol Intake by Levels of Other Ovarian Cancer Risk Factors, Continuous Model FactorCases Relative Risk (95% CI) P-value, test for Interaction Other Smoking Status Smoking Status Never914 0.97 (0.84-1.13) Past499 1.09 (0.96-1.23) Current285 1.05 (0.87-1.28) 0.52 Body Mass Index (kg/m 2 ) Body Mass Index (kg/m 2 ) <23 707 1.00 (0.90-1.11) 23-<25 23-<25416 1.06 (0.93-1.21) 25-<30 25-<30566 1.07 (0.93-1.23) >30 261 1.03 (0.80-1.33) 0.74