1. Overview Industry Overview Impacted Industries Science Business Issues Examples Where do you fit? Getting Involved Websites Other Resources

2. Statistics

3. Impact of Biotechnology Nutrition Human Health Crop Production Industrial Products Slide courtesy of Dick Kouri

4. The Business of Biotechnology Slide courtesy of Dick Kouri

5. $500 billion market New products: additives, botanicals, foods, and health foods that will improve nutrition Food Companies - $300B in Sales for the Top 30 Companies Additives - $4-8 B (Dominated by Roche) Growing Markets –Health Foods - $100 B –Botanicals – $0.5 B Nutrition Slide courtesy of Dick Kouri

6. Crop Production $786 billion market New products: herbicides, fungicides, fertilizers, seeds, and crop outputs that are high value and environmentally friendly Major Players –Monsanto –Bayer (Office in RTP) –Novartis –Syngenta Local Companies –Paradigm Genetics –Crop Solutions Slide courtesy of Dick Kouri

7. Industrial Products $135 billion market New products: fibers, industrial enzymes, specialty chemicals, paper and pulp for new and improved processes

8. Human Health $400 billion market New products: antibiotics, diagnostics, vaccines, nutraceuticals, and pharmaceuticals for disease prevention and treatment Major Players: All Big Pharma Local Companies –See NC Biotech website

9. Science Basics –Cell –DNA-RNA-protein Applications –Genomics Gene Therapies –Proteomics Activating process –Monoclonal Antibodies

10. Business Issues Time and funding Small molecules vs. molecule and problems –Pills vs. Injection Manufacturing –Complicated – can’t make enough

11. Examples Top drugs –Amgen Small Companies –AlphaVax

12. Where do MBAs fit in? Business Development –Business Plan Writing –Licensing and Partnerships Marketing and Sales –Big Pharma –Marketing Strategy -> Developing Partnerships –Market Research Market Sizing Competitive Intelligence –Sales Rotations Finance –Investor relations –Funding strategies for start-ups –Corporate finance for larger firms

13. How to Get Involved CED – www.cednc.orgwww.cednc.org –Volunteer for events through e-club –Biotech Forum – 2 nd Monday Biotech Club Events VCIC Competition Entrepreneurship Club Speaker Series

14. Websites Biotech Club website –List of applicable sites NC Biotech Center –www.ncbiotech.orgwww.ncbiotech.org

15. Other Resources Brookings Institution Report –www.brook.edu/dybdocroot/es/urban/publications/biotech.p dfwww.brook.edu/dybdocroot/es/urban/publications/biotech.p df PHRMA Report on New Medicine Development for Biotech –www.phrma.org/newmedicines/resources/2002-10-21.93.pdfwww.phrma.org/newmedicines/resources/2002-10-21.93.pdf S&P 500 Industry Overview – OCS Library From Alchemy to IPO – The Business of Biotechnology by Cynthia Robbins-Roth The Million Dollar Molecule by