1. Factor II Deficiency By Jessica Johnson Medical Terminology II December 2, 2004

2. Background Infant weighed 2.6 kg Apgar 8,9,9 Uncomplicated delivery Umbilical bleeding at birth Vitamin K given intra-muscular

3. What is it A congenital disorder Deficient blood clotting due to a low level of vitamin K Affects males and females with equal frequency =

4. Prothrombin Vitamin K- dependent proenzyme that functions in coagulation (helps the blood to clot)

5. Symptoms Umbilical cord bleeding at birth Nose bleeds Abnormal menstrual bleeding Abnormal bleeding after birth Bleeding after trauma Bleeding after surgery Easy bruising

6. Signs and Tests Prolonged prothrombin time (long clotting time) Prolonged partial thromboplastin time Factor II assay showing decreased activity Levels of prothrombin ranging from 2% to 50% of normal 2% -50%= normal

7. Treatments Mild cases –Plasma infusion Severe Cases –Prothrombin complex concentrates (PCCs) –Plasma replacement therapy

8. Prevention Genetic counseling Vitamin K