1. The Heart Cardiology

2. Physical Characteristics Situated between the lungs in the mediastinum About the size of a clenched fist Cone or pyramid shape, tilting to the left Apex - inferior portion Base - superior portion

3. Pericardium - 3 layers Fibrous pericardium - outer layer Serous pericardium - inner layer parietal layer visceral layer (epicardium) Pericardial cavity - space between the parietal and visceral layers that is filled with pericardial fluid Pericardial fluid - lubrication,reduces friction

4. Heart Wall Epicardium - outermost layer visceral pericardium Myocardium - middle layer cardiac muscle involuntary, striated, short, branched cells intercalated discs Endocardium - inner layer lines the chambers and covers the valves simple squamous epithelium

5. Heart Chambers Two upper atria ; two lower ventricles Atria are the receiving chambers Ventricles are the distributing chambers Interatrial septum separates atria Interventricular septum divides ventricles Auricles are external flaps Left ventricle very thick

7. Heart Valves Atrioventricular valves tricuspid (right) bicuspid or mitral (left) chordae tendineae papillary muscle Semilunar valves aortic semilunar pulmonary semilunar three pocketlike cusps

9. Valve Disorders Rheumatic Fever - group A, B-hemolytic Streptococcus pyogenes Heart Mumur stenosis incompetent valves Mitral valve prolapse (MVP)

10. Blood Flow through the Heart The heart receives blood from the superior vena cava, inferior vena cava and the coronary sinus Right atrium->tricuspid valve->right ventricle-> pulmonary semilunar valve-> pulmonary trunk>pulmonary arteries-> lungs-> pulmonary veins->left atrium->mitral valve->left ventricle>aortic semilunar valve -> aorta

11. Pulmonary & Systemic Circulation Pulmonary circulation - refers to blood going through the right side of the heart to the lungs Systemic circulation - involves the left heart. Oxygenated blood from the lungs flows into the left atrium, enters the left ventricle, out through the aorta into the body’s tissue, and back via systemic veins to the right atrium

12. Coronary Circulation The aorta branches into the left and right coronary arteries

13. Blood flow through myocardium Left coronary artery Anterior interventricular artery Circumflex artery Right coronary artery Posterior interventricular artery Marginal artery Arterial anastomoses

16. Venous Drainage Great cardiac veins Coronary sinus Right atrium

18. Cardiac Conduction System Sinoatrial (SA) node Pacemaker of the heart Atrioventricular (AV) node Atrioventricular bundle (Bundle of His) Left and right bundle branches Purkinje fibers Modification by the ANS and hormones

19. Cardiac Physiology

20. Electrocardiogram - ECG P wave - atrial depolarization QRS complex - ventricular depolarization T wave - ventricular repolarization Atrial repolarization is masked by the larger QRS complex

22. Arrhythmias Abnormal Heart Rhythms Heart block - blockage in the AV node Tachycardia - >100 beats per minute Bradycardia - <60 beats per minute Fibrillation - uncoordinated quivering Flutter - rapid contractions PVC - premature ventricular contraction PAC - preatrial contraction

23. Terms Myocardial infarction (MI) - heart attack Infarction - tissue death due to loss of blood supply Ischemia - decreased blood flow causing hypoxia Angina pectoralis - chest pain related to coronary problems

24. Cardiac Cycle Cardiac cycle consists of one complete cycle of contraction and relaxation Contraction phase - systole Relaxation phase - diastole Complete cycle - 0.8 seconds Phases : relaxation period, ventricular filling, ventricular systole Normal heart rate - 75 beats/minute

25. Cardiac Output CO = Stroke volume x Heart rate Amount of blood passing through a ventricle in 1 minute SV = Amount of blood that is pumped by a ventricle per beat (approx. 70 ml) HR = number of beats per minute

26. Examples Rest - CO = 70ml/beat x 75 beats/min = 5250ml/minute =5.25 liters/minute Exercise - CO = 140ml/beat x 150 beats/min = 21,000ml/minute = 21 liters /minute

27. Factors influencing stroke volume “Frank - Starling law of the heart” Critical factor = stretch of cardiac muscle Preload - how much blood enters a ventricle during diastole Contractility - forcefulness of a contraction Afterload - pressure needed before ventricle ejection occurs

28. Regulation of Heart Rate Cardiovascular Center Medulla Sympathetic nervous system Cardiac accelerator nerves Parasympathetic nervous system Vagus nerve Baroreceptors - monitor pressure aortic arch carotid arteries Chemoreceptors - monitor chemicals aortic/carotid bodies Hormones, age, fitness,gender