1. BY Ronald Mensah

2.   Introduction  Fluorination methods  Fluorination in Medical chemistry  Conclusion  Writing Component  References  Questions Outline

3.  Introduction  What is fluorine?  Location on the periodic table  Electronegativity  Ionization energy  Natural abundance http://www.ebi.ac.uk/chebi/searchId.do? chebiId=24065. accessed on 10/2/2014

4.   Electrophilic Fluorinations  Nucleophilic Fluorinations Procedures

5.  What occurs in electrophilic fluorination reaction?  Cationic fluorine atom  N-F and 0-F reagent  Removal of electron density Electrophilic Fluorination

6.  Electrophilic addition

7.   Direct displacement with fluoride  Protic vs aprotic solvent  tetrabutylammoniumfluoride(TBAF)  Other Regents  HF  (diethylamino)-sulfur trifluoride (DAST)  Use of transition metals Nucleophilic fluorination. http://www.sigmaaldrich.c om/catalog/product/aldric h/216143?lang=en&region= US

8.  Nucleophilic Fluorination mechanism H---F

9.   Orthogonal reactivity of Hydrogen and Fluoride  H + vs F +  H - vs F -  enzyme activity design  5-fluorouracil (5-FU)  pyridoxal phosphate (PLP)-dependent enzyme- catalyzed reactions Medicinal Chemistry

10.  5-fluorouracil (5-FU)

11.  DFMO (Eflornithine) http://upload.wikimedia.org/wikipe dia/commons/a/a2/Eflornithine_OD C_Reaction_Mechansim.png

12.  Conclusion

13. 

14.  References  Banks, Alton. "Fluorine." Journal of Chemical Education 67.5 (1990): 373. ACS. Web  Kirk, Kenneth L. "Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments." Organic Process Research & Development 12.2 (2008): 305-21.  Lal, G. Sankar, Guido P. Pez, and Robert G. Syvret. "Electrophilic NF Fluorinating Agents." Chemical Reviews 96.5 (1996): 1737-756. Print.

15.  Questions?