1. 1825 Erie Canal, linking the Hudson River to Lake Erie, is opened for traffic

2. 1830 President Jackson signs the Indian Removal Act, which authorizes the forced removal of Native Americans living in the eastern part of the country to lands west of the Mississippi RiverIndian Removal Act

3. 1831 Nat Turner, an enslaved African American preacher, leads the most significant slave uprising in American history. Nat Turner

4. 1836 Texas declares its independence from Mexico Texas

5. 1838 More than 15,000 Cherokee Indians are forced to march from Georgia to Indian Territory in present-day Oklahoma. Approximately 4,000 die from starvation and disease along the “Trail of Tears.”Cherokee IndiansIndian Territory

6. 1845 U.S. annexes Texas by joint resolution of Congress The term “manifest destiny” appears for the first time. It expresses the belief held by many white Americans that the United States is destined to expand across the continent.

7. 1846 U.S. declares war on Mexico in effort to gain California and other territory in Southwest

8. 1848 Gold is discovered at Sutter's Mill in California

9. 1850 Compromise of 1850: California is admitted as a free state, Utah and New Mexico territories are left to be decided by popular sovereignty, and the slave trade in Washington, DC, is prohibited. Compromise of 1850CaliforniaUtahNew Mexicopopular sovereignty, Washington, DC,

10. 1854 Congress passes the Kansas-Nebraska Act, establishing the territories of Kansas and Nebraska (May 30). The legislation repeals the Missouri Compromise of 1820 and renews tensions between anti- and proslavery factions.Kansas-Nebraska Act