1. A reason to do IT Running IT for a Global Biotech Company Roberto Tolini Manager Corporate Engineering CERN 05Jul2005

2. A reason to do IT  Our Industry  Our Company  Our IT Function  Our IT infrastructure Agenda

3. A reason to do IT Demographics - Aging population in industrialized countries and associated healthcare needs are growing A significant number of important medical needs remain unmet and a new set of diseases are emerging New technologies are accelerating the discovery process and could facilitate the discovery of new therapeutic agents The rapid evolution of medical practices and novel clinical approaches to address healthcare issues will lead to new opportunities (efficacy, safety, convenience, and pharmaeconomics) The Biotech Industry

4. A reason to do IT Biotech has delivered on its promises: - over 100 compounds now approved - several blockbusters Biotech R&D will continue to be productive: - Approximately 500 biotech compounds in development - A significant number of pending regulatory filings - Many major new drug approvals and launches expected Biotechnology is no longer a niche. Big Pharma is coming! Biopharmaceutical Benchmarks Source: Walsh G., Nature Biotechnology, Vol. 21, 8, Aug. 2003, p.867 The Biotech Industry

5. A reason to do IT  Our Industry  Our Company  Our IT Function  Our IT infrastructure Agenda

6. A reason to do IT Serono Profile Who we are: Fully integrated global biotech company (R&D, Mfg, M&S) with almost 100 years of history in biologic therapies operate in 45 countries sales in over 100 countries 4,600 employees worldwide 6 recombinant products on the world market revenues of $2.3 billions in 2004 Largest biotech company in Europe Third largest biotech company worldwide Platform of new technologies

7. A reason to do IT A Global Biotech Leader 3rd Biotech worldwide, 1st biotech outside USA 29% 45% 40% 63% 10% 47% 81% 65% Lead Product as % of Revenues 2003 Reported Revenues

8. A reason to do IT Reproductive Health Neurology: Multiple Sclerosis Growth and Metabolism Dermatology: Psoriasis Our Products

9. A reason to do IT Our types of proteins Human hormones (messages between organs) Human cytokines (messages between cells) Molecules which influence hormones and cytokines LIF Anastrozole IL18-BP Onercept TBP-1

10. A reason to do IT  Our Industry  Our Company  Our IT Function  Our IT infrastructure Agenda

11. A reason to do IT Application Hosting Services Voice & Data Telecom Services IT Research & Development IT Customer Value Delivery Governance Organisation Structure We concentrate our forces on five global strategic units

12. A reason to do IT Organisation Structure We created and manage three main regions USA Services 25% staff HQ Services 50% staff Affiliates Services 25% staff

13. A reason to do IT We are a global organisation of 140 employees supporting 4’600 users in more than 60 locations and from 30 different countries in the world. Global Presence North America  Argentina  Brazil  Uruguay  Venezuela  Colombia  Mexico Latin America  Australia  New-Zealand Japan Europe, Middle-East, Africa Asia-Pacific Oceania  Singapore  Korea  Hong-Kong  Taiwan  Thailand  China  Switzerland  France  UK  Germany  Austria  Netherlands  Sweden  Danemark  Finland  Norway  Czech Rep.  Slovakia  Poland  Lithuania  Russia  Croatia  Italy  Spain  Canada  USA  Puerto Rico  Portugal  Greece  Israel  South Africa  Egypt  Tunisia  Algeria  Morocco  Turkey  Jordan  Saudi Arabia  United Arab Em.

14. A reason to do IT  Our Industry  Our Company  Our IT Function  Our IT infrastructure Agenda

15. A reason to do IT Overall picture 2 main DataCenters: Geneva and Boston 2 main DataCenters: Geneva and Boston A mirror site has been created in Boston to maintain business continuity in case of major disaster Consolidation and centralization of all business applicationsConsolidation and centralization of all business applications Over the past 7 years, we have built a highly centralized IT environment. All subsidiaries of the Group access their enterprise application resources remotely in our headquarters. WW local sites WW local sites Telecom is playing a critical role in allowing WW sites to run business.

16. A reason to do IT IT environment overall picture Heterogeneous environments (AIX, Solaris, Windows, Linux, Novell Netware, etc…) Heterogeneous applications (ERP, Documentum, File Servers, Clinical, etc…) and storage (IBM ESS, HDS95xx and Centera)

17. A reason to do IT Some Statistics 3’000 Desktops 1’500 Laptops 20Me-mails/year35’000calls/year1’500cyber-attacks/year 400 Servers 500Applications 60 Terabytes of Data 120 Telecom Lines 100 New projects per year

18. A reason to do IT Facts What we have today: 400 servers in Datacenters > 10 storage systems WW (EMC2, HDS and IBM) 1 IBM3494 library and 1 disk library (HQ) 1 tape library in Boston 2 backup copies AND offsite archiving Daily backup amount: 500GB HQ and 100GB Boston Total data on library: around 42TB (HQ) Total offsite tapes: over 6000 And we are still growing…

19. A reason to do IT Main challenges Availability vs processing power We need to ensure application availability 24/7 Minimize downtime (SLA engagment) Provide appropriate service levels per application type Data growing Storage space increase Backup window shrinking Performances Long-term archiving (business and legal requirements) Data accessibility Data availability in a reasonable time Telecom connections WW  cost and peformances Restore  time and reliability Long-term archiving  technology AND accessibility

20. A reason to do IT Biotech market is rapidly expanding and full of challenges and oppurtunities Serono has a broad portfolio of products but it’s still investing in new therapeutic areas IT @ Serono has both the challenge to run business- related application and scientific application Our goal is to provide a scalable and flexible architecture able to fullfill technological and business requirements Today’s main challenges in the Business area are main about application availability and data growth rather than processing power. Summary