1. INDIANAUNIVERSITYINDIANAUNIVERSITY January 2002 INGEN's advanced IT facilities Craig A. Stewart stewart@iu.edu

2. INDIANAUNIVERSITYINDIANAUNIVERSITY License terms Please cite as: Stewart, C.A. INGEN's advanced IT facilities. 2002. Presentation. Presented at: Department of Medical Genetics (IU School of Medicine, Indianapolis, IN, 8 Jan 2002). Available from: http://hdl.handle.net/2022/15222 http://hdl.handle.net/2022/15222 Note: The same basic presentation was given repeatedly in various departments at the IU School of Medicine. Rather than store the same slide deck repeatedly, this example from early in 2002 was uploaded to ScholarWorks, representative of the slide deck used throughout the year of 2002. Other presentations given with this slide deck include: –Stewart, C.A. 2002. INGEN's advanced IT facilities. Presentation. 19 Mar, Department of Endocrinology, IU School of Medicine, Indianapolis, IN. –Stewart, C.A. 2002. INGEN's advanced IT facilities. Presentation. 20 May, 2002. School of Informatics, Indianapolis, IN. –Stewart, C.A. 2002. INGEN's advanced IT facilities. Presentation. 18 Jun, Wells Center, IU School of Medicine, Indianapolis, IN. –Stewart, C.A. 2002. INGEN's advanced IT facilities. Presentation. 15 Oct, Indiana Health Industry Forum meeting, Indianapolis, IN. –Stewart, C.A. 2002. INGEN's advanced IT facilities. Presentation. Presented to Division of of Nephrology, IU School of Medicine, Indianapolis, IN. 4 November, 2002. Except where otherwise noted, by inclusion of a source url or some other note, the contents of this presentation are © by the Trustees of Indiana University. This content is released under the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/). This license includes the following terms: You are free to share – to copy, distribute and transmit the work and to remix – to adapt the work under the following conditions: attribution – you must attribute the work in the manner specified by the author or licensor (but not in any way that suggests that they endorse you or your use of the work). For any reuse or distribution, you must make clear to others the license terms of this work. 2

3. INDIANAUNIVERSITYINDIANAUNIVERSITY IT@IU in a nutshell Academic programs in IT through computer science, library and information sciences, engineering and technology, and most notably through new School of Informatics CIO: Vice President Michael A. McRobbie ~$100M annual budget Technology services offered university- wide

4. INDIANAUNIVERSITYINDIANAUNIVERSITY IU School of Medicine in a nutshell Located primarily at IUPUI 2 nd largest School of Medicine in the US History of accomplishment in identifying genetic basis of disease (certain forms of alcoholism, Huntington ’ s, bipolar disorder) Key assetts: –Regenstrief Institute –Imaging

5. INDIANAUNIVERSITYINDIANAUNIVERSITY Indiana Genomics Initiative Funded by a 3-year, $105M grant from the Lilly Endowment (a private charitable trust). Intended to be seed money that is heavily leveraged Goals: –Perform basic and applied research that will result in improved human health and health care. –Enhance central Indiana ’ s high-tech economy http://www.ingen.iu.edu/

6. INDIANAUNIVERSITYINDIANAUNIVERSITY INGEN Comprised of a mix of Programs (primary research areas) Cores (supportive functions, which may also be research areas in their own right). Direct oversight by President Brand; lead by Executive Committee (which includes VP McRobbie); general operational guidance by Operations Committee (Program & Core Directors)

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8. INDIANAUNIVERSITYINDIANAUNIVERSITY Major Accomplishments to date IU ’ s Teraflop SP Recruitment of Eric Meslin as Director, IU Center for Bioethics (and InGen Bioethics core) Genetics department head hire imminent Bioinformatics director hire close

9. INDIANAUNIVERSITYINDIANAUNIVERSITY New Initiatives Central Indiana Life Sciences Initiative –Central Indiana Corporate Partnership (CICP) –City of Indianapolis –Indiana University –Purdue University –Indiana Health Industry Forum (IHIF) –$1.5B total investment (this includes existing as well as newly committed funds) $12M in new Indiana Proteomics Consortium, a commercial venture between Eli Lilly and Co., ARTI (IU), and the Purdue Research Foundation

10. INDIANAUNIVERSITYINDIANAUNIVERSITY IT and InGen InGen ’ s IT core is a critical part of the infrastructure for the initiative as a whole –Supercomputing –Massive Data Storage –Visualization IT is one of the paths by which InGen should enhance the Indiana Economy

11. INDIANAUNIVERSITYINDIANAUNIVERSITY Oct 17 2001 IU/IBM announcement IU tripled the capacity of its IBM, to > 1 TFLOPS (a trillion mathematical operations per second). IU ’ s SP is the largest university-owned supercomputer in the US Large part of this acquisition made possible via funding from InGen IU and IBM also announced a partnership in developing new supercomputer applications for the life sciences “ … The teraflop supercomputer is a key first component of INGEN's IT infrastructure and will provide a major boost to scientific progress at IU in this area. “ IU Vice President fpr Information Technology & CIO Michael A. McRobbie

12. INDIANAUNIVERSITYINDIANAUNIVERSITY Photo: Tyagan Miller. May be reused by IU for noncommercial purposes. To license for commercial use, contact the photographer

13. INDIANAUNIVERSITYINDIANAUNIVERSITY IBM SP highlights 1.005 TFLOPS, currently 50 th on Top500 list 632 processors 484 GB total memory Mostly Power3+, but includes one 16-processor Power4-based Regatta node To be distributed across IUB and IUPUI campuses using I-Light infrastructure

14. INDIANAUNIVERSITYINDIANAUNIVERSITY Massive Data Storage IU has a large massive data storage system based on IBM and STK tape robotic systems. A new STK storage silo was just installed in Indianapolis. These will be expanded with 100s of TeraBytes (TBs) of tape storage in order to support INGEN IU ’ s massive data storage system is based on HPSS (High Performance Storage System) which provides for excellent security. Mirrored storage in Indianapolis and Bloomington should provide safety in data storage

15. INDIANAUNIVERSITYINDIANAUNIVERSITY Photo: Tyagan Miller. May be reused by IU for noncommercial purposes. To license for commercial use, contact the photographer

16. INDIANAUNIVERSITYINDIANAUNIVERSITY Advanced Visualization UITS, IU School of Medicine, and IUPUI Computer & Information Science have already collaborated to create 3-DIVE (3-D Interactive Volume Explorer) InGen will add 3-D visualization environments to the IU School of Medicine to enable new ways of gaining insight in biomedical research

17. INDIANAUNIVERSITYINDIANAUNIVERSITY 3-DIVE

18. INDIANAUNIVERSITYINDIANAUNIVERSITY Sun E10000 IU is a Sun “ Center of Excellence ” and plans to pursue collaborative research with Sun in the area of Chemical Informatics Photo: Tyagan Miller. May be reused by IU for noncommercial purposes. To license for commercial use, contact the photographer

19. INDIANAUNIVERSITYINDIANAUNIVERSITY Example INGEN IT development projects Parallel techniques for rendering PET scan images Protein Family Annotator (Possible IBM partnership project) Computational phylogenetics Biologist ’ s Portal DiscoveryLink as a means to interconnect IU School of Medicine databases (Possible IBM partnership project)

20. INDIANAUNIVERSITYINDIANAUNIVERSITY AVIDD Distributed facility for management, Analysis, and Visualization of Instrument- Driven Data $1.8M grant from NSF Consists of computational, data storage, and visualization components

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22. INDIANAUNIVERSITYINDIANAUNIVERSITY Critical elements Distributed Linux cluster, initially IA32, later addition of McKinley-based nodes Distributed visualization environments, including small-scale devices placed in individual laboratories Capability to handle large data sets and do “ pre-emptive processing ” Educational component, especially at IUN

23. INDIANAUNIVERSITYINDIANAUNIVERSITY General HPC strategy thoughts Maintenance prepaid, bundled in with purchase Vendor partnerships large and small Programming support and outreach area critical component of expanding fields affected and number of users HPC systems become attractors for faculty hires

24. INDIANAUNIVERSITYINDIANAUNIVERSITY Important URLs University Information Technology Services: www.indiana.edu/~uits/ –InGen IT Core: www.indiana.edu/~rac/bioinformatics/ingen.ht ml IU Teraflop SP announcement: www.indiana.edu/~rac/outreach.html IT@IU: it.iu.edu