1. “If I could do it over again, I’d publish that paper in PLoS Biology.” James Watson 50 th anniversary of the publication of DNA structure Eagle Pub, Cambridge, U.K.

3. What is the Public Library of Science?

4. A non-profit organization of scientists committed to making the world’s scientific and medical literature a public resource.

5. How?

6. By promoting open-access publishing,

7. By promoting open-access publishing, generating tools for mining scientific texts and data,

8. By promoting open-access publishing, generating tools for mining scientific texts and data, and making the literature comprehensible to non-specialists.

9. Why is open access important?

10. For authors to reach the largest possible audience.

11. For readers to have access to the entire literature in a given field— all in one information space.

12. For downloading, printing, copying, and archiving articles.

13. For full-text searching and mining beyond boolean text searches.

15. Speaking of “pay to read them,”

16. did you know that

17. science publishing is a $9 billion industry?

18. science publishing is a $9 billion industry? And that a few dominant corporations take profit margins that often exceed thirty percent?

19. Yet they archive papers in disparate,

20. Yet they archive papers in disparate, expensive-to-access,

21. Yet they archive papers in disparate, expensive-to-access, hard-to-search information spaces.

22. It doesn’t have to be that way.

24. Nine Core Principles

25. Open Access

26. Anyone, anywhere with an internet connection can read our journals,

27. Open Access Anyone, anywhere with an internet connection can read our journals, search them in a centralized information space,

28. Open Access Anyone, anywhere with an internet connection can read our journals, search them in a centralized information space, and share their content with anyone else.

29. Open Access Anyone, anywhere with an internet connection can read our journals, search them in a centralized information space, and share their content with anyone else.

30. Open Access Scientific Integrity

31. Open Access Scientific Integrity Scientific quality and relevance are the sole considerations in editorial decisions.

32. Open Access Scientific Integrity Scientific quality and relevance are the sole considerations in editorial decisions.

33. Open Access Scientific Integrity Excellence

34. Open Access Scientific Integrity Excellence We aim for it.

35. Open Access Scientific Integrity Excellence We aim for it. In everything we do.

36. Open Access Scientific Integrity Excellence We aim for it. In everything we do.

37. Open Access Scientific Integrity Excellence Breadth

38. Open Access Scientific Integrity Excellence Breadth PLoS Biology today...

39. Open Access Scientific Integrity Excellence Breadth PLoS Biology today... PLoS Medicine October 2004...

40. Open Access Scientific Integrity Excellence Breadth PLoS Biology today... PLoS Medicine October 2004... And that’s just the beginning.

41. Open Access Scientific Integrity Excellence Breadth PLoS Biology today... PLoS Medicine October 2004... And that’s just the beginning.

42. Open Access Scientific Integrity Excellence Breadth Cooperation

43. Open Access Scientific Integrity Excellence Breadth Cooperation We prefer to work with other publishers and organizations than to work alone.

44. Open Access Scientific Integrity Excellence Breadth Cooperation We prefer to work with other publishers and organizations than to work alone.

45. Open Access Scientific Integrity Excellence Breadth Cooperation Financial Fairness

46. Open Access Scientific Integrity Excellence Breadth Cooperation Financial Fairness We charge a fair price to authors who can afford it.

47. Open Access Scientific Integrity Excellence Breadth Cooperation Financial Fairness We charge a fair price to authors who can afford it.

48. Open Access Scientific Integrity Excellence Breadth Cooperation Financial Fairness Community Engagement

49. Open Access Scientific Integrity Excellence Breadth Cooperation Financial Fairness Community Engagement We were founded as a grassroots organization,

50. Open Access Scientific Integrity Excellence Breadth Cooperation Financial Fairness Community Engagement We were founded as a grassroots organization, and we’re committed to remaining one.

51. Open Access Scientific Integrity Excellence Breadth Cooperation Financial Fairness Community Engagement We were founded as a grassroots organization, and we’re committed to remaining one.

52. Open Access Scientific Integrity Excellence Breadth Cooperation Financial Fairness Community Engagement Internationalism

53. Open Access Scientific Integrity Excellence Breadth Cooperation Financial Fairness Community Engagement Internationalism Science has no borders.

54. Open Access Scientific Integrity Excellence Breadth Cooperation Financial Fairness Community Engagement Internationalism Science has no borders.

55. Open Access Scientific Integrity Excellence Breadth Cooperation Financial Fairness Community Engagement Internationalism Science Is a Public Resource

56. Open Access Scientific Integrity Excellence Breadth Cooperation Financial Fairness Community Engagement Internationalism Science Is a Public Resource Especially when the public pays for it.

57. Open Access Scientific Integrity Excellence Breadth Cooperation Financial Fairness Community Engagement Internationalism Science Is a Public Resource Especially when the public pays for it.

58. Financial Fairness Community Engagement Science Is a Public Resource Open Access Scientific Integrity Excellence Internationalism Breadth Cooperation

59. Financial Fairness Community Engagement Science Is a Public Resource Open Access Scientific Integrity Excellence Internationalism Breadth Cooperation

60. Financial Fairness Community Engagement Science Is a Public Resource Open Access Scientific Integrity Excellence Internationalism Breadth Cooperation

61. Lead the Next Scientific Revolution. Publish Your Best Work in

62. Lead the Next Scientific Revolution. Publish Your Best Work in

63. Why again?

64. It’s good for science.

65. And you’ll be in good company.

66. So Support Open Access.

67. Everywhere.

72. www.plos.org