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Organ-System-Based Integration of Biochemistry: Cells Do It; Can We Do It as Well? Eric Niederhoffer Southern Illinois University School of Medicine

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Presentation on theme: "Organ-System-Based Integration of Biochemistry: Cells Do It; Can We Do It as Well? Eric Niederhoffer Southern Illinois University School of Medicine"— Presentation transcript:

1 Organ-System-Based Integration of Biochemistry: Cells Do It; Can We Do It as Well? Eric Niederhoffer Southern Illinois University School of Medicine http://www.ebi.ac.uk/microarray/biology_intro.html nutrition informational macromolecules hemostasis/thrombosis cytoskeleton/extracellular matrix extracellular/intracellular communications bioenergetics/metabolism proteins/enzymes

2 Organ-System-Based Integration of Biochemistry Basic Sciences Clinical Sciences Y1 (Carbondale) Y2Y3 clerkships Y4 electives CRR SSB ERG HII C NB ERG Anatomy BSS Biochemistry Doctoring Genetics Histology Pharmacology Physiology PHP Doctoring Genetics Immunology Microbiology Neoplasia Pathology Pharmacology Radiology

3 CRR Unit Organization SAQs (mc, T/F, short answers) MU & EOU Exams (clinical scenarios) Familial hyperlipidemia nutrition/metabolism Genetics MC SOB MC Lifestyle MC CVD MC F&E MC Shock MC Collagen/anemia Nutrition Surfactant G proteins/ signal transduction Clinical markers G proteins/ signal transduction Electrolyte imbalance Cholesterol/lipoproteins/plaques/lipid processing SCD ASD PE COPD Arrhythmia MI PSGN CHF Hb gene/product/defect Glycolysis/2,3-BPG, PPP/GSH RBC structure HbO 2 /CO 2 ECM/proteases/antiproteases/  1AT Chem panels G proteins/signal transduction Coagulation/clinical markers Cardiac markers Amino acid processing/urea cycle Ion channels/membrane transport ATP production Overview of gene expression Ion channels/action potentials Thrombolytic agents Muscle contraction/energy production Filtration barrier Clinical markers Clinical markers/BNP

4 ePBLM Organization Sickle Cell Disease Red blood cells: structure and function, glycolysis (2,3-BPG), pentose phosphate pathway, glutathione Introduction to genetics (basic principles) Introduction to molecular biology of gene expression: transcription, translation, protein processing Hemoglobin structure: HbA (  2  2 ), HbF (  2  2 ), HbA 2 (  2  2 ), HbS; overview of hemoglobin function Complete blood count: RBC parameter (Hct, Hb content, MCV, MCHC) and WBCs Structure and function of the spleen Pathogenesis and natural history of sickle cell disease Introduction to child development: Denver development chart, normal milestones Introduction to immunology: cause of inflammation and pain (cytokines and phagocytes)

5 The Best and Worst at Times Best Features Integration with other disciplines/clinical medicine overlap/redundancy of topics clinical relevance low priority Worst Features Perceived orphan topics Competition with other disciplines Non-biochemistry resources

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