Presentation is loading. Please wait.

Presentation is loading. Please wait.

Classification of anemia Functional classification: Functional classification: Hypoproliferative destruction (infective hematopoiesis). Clinical classification:

Similar presentations


Presentation on theme: "Classification of anemia Functional classification: Functional classification: Hypoproliferative destruction (infective hematopoiesis). Clinical classification:"— Presentation transcript:

1 Classification of anemia Functional classification: Functional classification: Hypoproliferative destruction (infective hematopoiesis). Clinical classification: Clinical classification: Causes of anemia (blood loss, IDA, hemolysis). Quantitative classification: Quantitative classification: HematocritHematocrit HemoglobinHemoglobin Blood cell indices (MCV, MCH, MCHC).Blood cell indices (MCV, MCH, MCHC). Reticulocytes count.Reticulocytes count.

2 Red cell indices MCV (mean corpuscular volume) The average volume of RBC The average volume of RBCHct =  10(fl) RBC count (m/µL) e.g. Hct= 40% RBC=5.0 (m /µL) MCV= 40/5.0  10 = 80 fl NR= fl

3 MCH (mean corpuscular hemoglobin) The average content of Hb in average RBC. The average content of Hb in average RBC. It is directly proportional to the amount of Hb and RBC size. It is directly proportional to the amount of Hb and RBC size. Hb (m/µL) RBC count (m/µL)  10 (pg) MCH = e.g. Hb = 14 g/dl (m/µL) RBC = 4 (m/µL) MCH= 14/4  10 = 35 pg NR= pg

4 MCHC (mean corpuscular hemoglobin concentration) Express the average concentration of hemoglobin per unit volume of RBC. Express the average concentration of hemoglobin per unit volume of RBC. It defined as the ratio of the weight of hemoglobin to volume of RBC. It defined as the ratio of the weight of hemoglobin to volume of RBC. Hb (g/dl) Hct (%)  100 (%) MCHC= e.g. Hb = 14 g/dl Hct = 45 % MCHC 14/45  100 = 31% NR= 32-36%

5 Symptoms of Anemia Hemoglobin/Hematocrit Normal or High Check other Causes of symptoms e.g. Cardiac Pulmonary Low RBC indices MCV < 80 MCHC < 32 Serum iron and Total Iron binding capacity of Ferritin Low Iron IDA, chronic diseases, Renal diseases Normal Hb electrophoresis for Thala. High Iron BM exam For Sideroblastic anemia MCV=80-96 History of acute blood loss Auto immune Hemolytic anemia Anemia of chronic Diseases Anemia of infection MCV > 98 B12 and folate levels Low B12 PA, GI problems Severe malnutrition. Low folate Folate malnutrition GI problems Liver disease High or Normal MPD Liver Disease

6 Normal red cell morphology

7 Hypochromic Hyperchromic Macrocytic Microcytic

8 IDA Target cells Sickle cells Poikiolocytosis Stomatocytes Acanthocytes Ovalocyte Spherocytes Nucleated RBC


Download ppt "Classification of anemia Functional classification: Functional classification: Hypoproliferative destruction (infective hematopoiesis). Clinical classification:"

Similar presentations


Ads by Google