Presentation on theme: "Classification of anemia"— Presentation transcript:
1 Classification of anemia Functional classification:Hypoproliferative destruction (infective hematopoiesis).Clinical classification:Causes of anemia (blood loss, IDA, hemolysis).Quantitative classification:HematocritHemoglobinBlood cell indices (MCV, MCH, MCHC).Reticulocytes count.
2 Red cell indices MCV (mean corpuscular volume) The average volume of RBCHct= 10 (fl)RBC count (m/µL)e.g. Hct= 40%RBC=5.0 (m /µL)MCV= 40/5.0 10 = 80 flNR= fl
3 MCH (mean corpuscular hemoglobin) The average content of Hb in average RBC.It is directly proportional to the amount of Hb and RBC size.HbMCH = (pg)RBC count (m/µL)e.g. Hb = 14 g/dlRBC = 4 (m/µL)MCH= 14/4 10= 35 pgNR= pg
4 MCHC (mean corpuscular hemoglobin concentration) Express the average concentration of hemoglobin per unit volume of RBC.It defined as the ratio of the weight of hemoglobin to volume of RBC.Hb (g/dl)MCHC= (%)Hct (%)e.g. Hb = 14 g/dlHct = 45 %MCHC 14/45 100 = 31%NR= 32-36%
5 Hemoglobin/Hematocrit Symptoms of AnemiaNormal or HighHemoglobin/HematocritCheck otherCauses of symptomse.g. Cardiac PulmonaryLowRBC indicesMCV > 98MCV < 80MCHC < 32MCV=80-96History of acute blood lossAuto immune Hemolytic anemiaAnemia of chronic DiseasesAnemia of infectionB12 and folate levelsSerum iron and Total Iron binding capacity of FerritinLow IronIDA, chronic diseases, Renal diseasesNormalHb electrophoresis for Thala.High IronBM examFor Sideroblastic anemiaLow B12PA, GI problemsSevere malnutrition.Low folateFolate malnutritionGI problemsLiver diseaseHigh or NormalMPDLiver Disease
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