1. Acute Treatment of Hyponatraemia

2. Sodium concentration less than 135meq/L ICCU treats those with much lower levels, or very acute drops (as they are symptomatic)

3. Background Remember the value is a concentration Hyponatraemia is usually XS water Water balance is mediated via ADH In hyponatraemia there’s usually either an ADH problem (too much), or it has been overwhelmed (primary polydipsia)

4. Pseudohyponatraemia Serum is 93% water and electrolytes, 7% fat and protein. If fat increased (e.g. Propofol infusion syndrome) or protein increased (e.g. myeloma) the water component proportion is reduced. The Na conc of the water component is unchanged. The Na conc of the sample is reduced.

5. Osmolarity 2(Na+K)+Urea+Glc Urea is an ineffective solute as crosses cell membrane. The effects of Glucose usually small as rarely high. Na main determinant As water moves freely, this is the osmolarity of total body water.

6. Osm is usually reduced in hyponatraemia As expected (osm = 2(Na+K)+Urea+Glc) Unless the issue is: –Advanced renal failure Can’t pass dilute urine so water can’t be excreted, which would decrease osm BUT urea increases. –The addition of osmolar active molecules drawing water into the ECF. Mannitol, Glucose, Alcohol – Gap between measured and calculated

7. High ADH Volume depletion leading to ADH & RAAS activation. –True (D&V, Bleeding, Thiazide diuretics) –Effective Vasodilation in liver fauilure Pump failure (cardiac) –Nb in these conditions chronic Na conc <130 = end stage SIADH

8. Endocrine Causes Hypothyroid Addisons Mechanisms unclear

9. Others Exercise & Ecstasy –XS fluid intake combined with RAAS activation Primary Polydipsia –Oral water intake so high that ADH overwhelmed.

10. History & Examination Volume Status Signs Ht, renal, liver failure Hypothyroidism & Addisons Causes of volume depletion Lung Ca or neurological disorders

11. Check Serum Osm Expect it to be low. If high consider osmolar active molecules & advanced renal failure

12. Check Urine Osm This is to exclude Primary Polydipsia & to track treatment response. If primary polydipsia maximally dilute urine (osm<100) Urine osm will decrease if a cause of increased ADH is treated (in reality this is only true hypovolaemia) It will be fixed in SIADH – see later

13. Urine Sodium Conc To help dx hypovolaemia. If present urine Na conc <25 – the body is retaining salt and water (more water than salt).

14. Treatment If volume deplete give volume If overloaded fluid restrict If SIADH fluid restrict Treat underlying disease Treat more quickly if acute (<1 day) Treat more quickly if seizures or unconscious

15. Demyelination A complication of over-enthusiastic correction. Not a risk if <1 day as the CNS protective measures are not yet in place, and it is these measures that cause the issue. Raise conc by <10/24hrs and <1/hour A rise of 5-6 is said to be enough to correct seixures / decreased LOC

16. Fluid restriction Aim is to decrease water Commonly 800ml/day Must be <UOP or isn’t restriction! If UOP <800 other measures required.

17. If volume depleted Isotonic saline (although it won’t be isotonic as osm decreased). –Is a salt load (fluid conc > serum conc) –Switches off ADH –Treats the underlying disorder

18. TBW (L) = 60% weight (1L=1kg) A 50kg woman has a Na conc of 110meq/L Her TBW is therefore 30L (0.6x50)

19. TBW (L) = 60% weight (1L=1kg) A 50kg woman has a Na conc of 110meq/L Her TBW is therefore 30L (0.6x50) Her total body sodium amount is 110x30 = 3300meq

20. TBW (L) = 60% weight (1L=1kg) A 50kg woman has a Na conc of 110meq/L Her TBW is therefore 30L (0.6x50) Her total body sodium amount is 110x30 = 3300meq ECV = 1/3 of TBW = 10L Her extracellular Na amount is 110X10 = 1100meq

21. TBW (L) = 60% weight (1L=1kg) A 50kg woman has a Na conc of 110meq/L Her TBW is therefore 30L (0.6x50) Her total body sodium amount is 110x30 = 3300meq ECV = 1/3 of TBW = 10L Her extracellular Na amount is 110X10 = 1100meq She is given 1000ml 0.9%NaCl, containing 154meq Na Extracelular Na amount is now 1254 (1100+154) TBW is now 31L

22. TBW (L) = 60% weight (1L=1kg) A 50kg woman has a Na conc of 110meq/L Her TBW is therefore 30L (0.6x50) Her total body sodium amount is 110x30 = 3300meq ECV = 1/3 of TBW = 10L Her extracellular Na amount is 110X10 = 1100meq She is given 1000ml 0.9%NaCl, containing 154meq Na Extracelular Na is now 1254 (1100+154) TBW is now 31L Her new Na conc is 3454/31 = 111meq/L

23. TBW (L) = 60% weight (1L=1kg) A 50kg woman has a Na conc of 110meq/L Her TBW is therefore 30L (0.6x50) Her total body sodium amount is 110x30 = 3300meq ECV = 1/3 of TBW = 10L Her extracellular Na amount is 110X10 = 1100meq She is given 1000ml 0.9%NaCl, containing 154meq Na Extracelular Na is now 1254 (1100+154) TBW is now 31L Her new Na conc is 3454/31 = 111meq/L Her ECV is now 1254/110 = 11.4L –(It has increase by >1L as the sodium has drawn water out of the cells)

24. TBW (L) = 60% weight (1L=1kg) A 50kg woman has a Na conc of 110meq/L Her TBW is therefore 30L (0.6x50) Her total body sodium amount is 110x30 = 3300meq ECV = 1/3 of TBW = 10L Her extracellular Na amount is 110X10 = 1100meq She is given 1000ml 0.9%NaCl, containing 154meq Na Extracelular Na is now 1254 (1100+154) TBW is now 31L Her new Na conc is 3454/31 = 111meq/L Her ECV is now 1254/110 = 11.4L So in hypovolaemia 1L saline increases Na conc by about 1meq/L and increases ECV by just over a litre.

25. SIADH Increased ADH whatever the water status is (inappropriate) Sodium handling is intact (regulated by Aldosterone) Pathogenesis –Increased ADH leads to increased TBW and decreased Na conc. –The hypervolaemia triggers increased Na and water loss –The patient is now euvolaemic but with decreased sodium amount –Potassium is also excreted to reduce cellular swelling

26. Causes Medication Surgery Malignancy Infection CNS disease It’s therefore not a diagnosis on it’s own!

27. Treatment Fluid restriction if possible Not possible if: –Seizures or unconcious –Associated with SAH (risk of vasospasm) Nb differentiate from CSW by volume status In these situations give fluid

28. Fluid Tx in SIADH The solute conc in the administered fluid MUST be > that of the urine. In SIADH the urine Osm is fixed (as ADH is unchanged) so if increased solute increased urine output & vice versa. The aim is to make the patient loose water not gain Na

29. If urine osm is 616meq/L and serum Na conc is 120meq/L 1000ml 0.9%NaCl given (osm = 308) –Initially Na conc will rise (154>120) –But the increased Na will be excreted (not hypovolaemic and RAAS system unaffected) –To excrete 308 osm with a fixed urine osm of 616, 500ml urine will be passed. –1000ml in, 500ml out so water increased, Na conc decreases further.

30. So in SIADH…. Fluid restrict if you can Give hypertonic saline if you can’t