Presentation on theme: "Essentials of Primary Care 2008: Anxiety Disorders"— Presentation transcript:
1Essentials of Primary Care 2008: Anxiety Disorders Descartes Li, M.D.Associate Clinical ProfessorUniversity of California, San FranciscoWhat are the emotions? Emotions not that easily definedSad, mad, glad and scaredDefine anxiety: “Fight or Flight”Anxiety (also called solicitude) is a psychological and physiological state characterized by cognitive, somatic, emotional, and behavioral components. These components combine to create the painful feelings that we typically recognize as anger, fear, apprehension, or worry. Anxiety is often accompanied by physical sensations such as heart palpitations, nausea, chest pain, shortness of breath, stomach aches, or headache. The cognitive component entails expectation of a diffuse and certain danger. Somatically the body prepares the organism to deal with threat (known as an emergency reaction): blood pressure and heart rate are increased, sweating is increased, bloodflow to the major muscle groups is increased, and immune and digestive system functions are inhibited (the 'fight or flight' response). Externally, somatic signs of anxiety may include pale skin, sweating, trembling, and pupillary dilation. Emotionally, anxiety causes a sense of dread or panic and physically causes nausea, diarrhea, and chills. Behaviorally, both voluntary and involuntary behaviors may arise directed at escaping or avoiding the source of anxiety and often maladaptive, being most extreme in anxiety disorders. However, anxiety is not always pathological or maladaptive: it is a common emotion along with fear, anger, sadness, and happiness, and it has a very important function in relation to survival.Neural circuitry involving the amygdala and hippocampus is thought to underlie anxiety. When confronted with unpleasant and potentially harmful stimuli such as foul odors or tastes, PET-scans show increased bloodflow in the amygdala. In these studies, the participants also reported moderate anxiety. This might indicate that anxiety is a protective mechanism designed to prevent the organism from engaging in potentially harmful behaviors.
2Anxiety Disorders Epidemiology Assessment and Diagnosis Review of Anxiety DisordersTreatments
3QuestionWhat is the prevalence of panic disorder in patients with coronary artery disease?2%5%10%50%75%
4QuestionWhat is the prevalence of panic disorder in patients with coronary artery disease?Answer: % (choices 3 or 4)Fleet et al. Is panic disorder associated with coronary artery disease? A critical review of the literature. J Psychosom Res 2000 Apr-May;48(4-5):
5Epidemiology Disorder Prevalence in primary care population (n=965) Twelve-month prevalence estimates for anxiety in the general population: 18.1% (Arch Gen Psychiatry. 2005;62: )DisorderPrevalence in primary care population (n=965)PTSD8.6% (83)GAD7.6% (73)Panic d/o6.8% (66)Social phobia6.2% (60)At least one d/o19.5% (188)Kroenke K et al. Anxiety Disorders in Primary care: Prevalence, Impairment, Comorbidity, and Detection. Ann Intern Med. 2007;146:
6Cardiac Presentations of Anxiety GAD was the primary dx among 20% of patients with atypical chest pain (1).55% of patients with chest pain and normal coronary arteries (2).50% of patients seeking cardiac evaluation (3).Kane, F et al. Angina as a symptom of psychiatric illness. Southern Med J 1988;81:Wulsin LR et al. Axis I disorders in ER patients with atypical chest pain. Int J Psychiatry Med 1991;21:37-46Logue MB et al. Generalized anxiety disorder patients seek evaluation for cardiological symptoms at the same frequency as patients with panic disorder. J Psychiatr Res 1993;27:55-59.We retrospectively studied all patients who had normal coronary angiograms at The Methodist Hospital during the year 1984 (8% of all angiograms). Patients were surveyed eight to 18 months after angiography. Of the 216 patients (83% of total sample), 130 were female and 86 male. Sixty-three percent of the women and 50% of the men satisfied the criteria for generalized anxiety disorder, and 20% satisfied the criteria for panic attacks. On the Brief Symptom Inventory (BSI) Somatization Scale, 64% had scores above the average reported for psychiatric outpatients. Eighty-one percent received only reassurance about the absence of heart disease, and 25% received continuing nitrate therapy in the absence of heart disease. A majority of these patients remain untreated functional "cardiac neurotics" with untreated anxiety symptoms. We make suggestions regarding a clinical profile to identify these patients and appropriate measures to avoid prolonged disability.To examine the contribution of psychopathology to emergency room (ER) visits for atypical chest pain, we administered two screening measures and the Structured Clinical Interview for DSM III-R (SCID) to thirty-five subjects within seventy-two hours of their ER visit. Follow-up SCID interviews were completed in thirty subjects at five to twelve months. Sixty percent of the sample had an initial Axis I diagnosis, predominately affective (34%) and anxiety (46%) disorders. Forty percent had multiple diagnoses initially. The most common diagnoses were panic disorder (31%) and major depression (23%). At follow-up 47 percent had Axis I diagnoses, 30 percent had multiple diagnoses, with only slightly decreases rates for panic disorder (27%) and major depression (17%). Many subjects had lost, gained, or switched diagnoses by follow-up, in spite of one consistent rater and a few subjects seeking treatment. ER physicians often do not recognize these psychiatric disorders in chest pain patients. The high risk of suicide in panic disorder and depression, and the high cost of disability in recurrent chest pain make it essential that ER physicians include these disorders in the differential of atypical chest pain.Although panic disorder (PD) and generalized anxiety disorder (GAD) have similar somatic symptoms, panic attacks with chest pain and/or palpitations may seem more likely to be mistaken for heart attacks because of their acute onset. One would therefore expect that PD patients are more likely than GAD patients to seek cardiological consultations. In a survey of 146 PD and 154 GAD patients entering a multi-site drug trial, we found virtually identical rates of such consults. Approximately 50% of each patient group sought medical evaluation for cardiac symptoms. Furthermore, 40% of each group had standard treadmill evaluations and 33% reported having an echocardiogram. This study suggests that future epidemiological studies in cardiology populations should include probes for generalized anxiety disorder.
7GI Presentations of Anxiety: Irritable Bowel Syndrome StudyLifetime prevalence of GADCurrent rate of GAD1. Walker et al. (n=47)58%25%2. Lydiard et al. (n=35)28%13%Walker EA et al. Psychiatric illness and irritable bowel syndrome: a comparison with inflammatory bowel disease . Am J Psychiatry 1990;147:Structured psychiatric interviews and psychological self-report measures were administered to 28 patients with irritable bowel syndrome and 19 patients with inflammatory bowel disease. Significantly more of the patients with irritable bowel syndrome had lifetime diagnoses of major depression, somatization disorder, generalized anxiety disorder, panic disorder, and phobic disorder. They had significantly more medically unexplained somatic symptoms, and most had suffered from psychiatric disorders, particularly anxiety disorders, before the onset of their irritable bowel symptoms.2. Lydiard RB et al. Prevalence of psychiatric disorders in patients with irritable bowel syndrome. Psychhosomatics 1993;34:Thirty-five patients with irritable bowel syndrome were referred from the gastroenterology service and underwent structured psychiatric interviews to assess the prevalence of psychiatric illness. Thirty-three (94%) of 35 patients were found to have a lifetime prevalence of any Axis I disorder; the predominant diagnoses were mood and anxiety disorders. Theoretical and practical implications of these findings are discussed.1. Walker EA et al. Psychiatric illness and irritable bowel syndrome: a comparison with inflammatory bowel disease . Am J Pyshciatry 1990;147:2. Lydiard RB et al. Prevalence of psychiatric disroders in patients with irritable bowel syndrome. Psychhosomatics 1993;34:
8Anxiety Disorders Epidemiology Assessment and Diagnosis Review of Anxiety DisordersTreatments
9Case VignetteA 27-year-old woman has dissociative (feelings of unreality) symptoms accompanied by nightmares, hypervigilance, and anger that continue 6 weeks after being a victim of an armed robbery and assault. What diagnosis, if any, should she receive?Acute Stress DisorderPost-Traumatic Stress DisorderGeneralized anxiety disorderObsessive-Compulsive DisorderAnxiety Disorder, not other specified
10Case Vignette Answer Post-Traumatic Stress Disorder Acute Stress Disorder lasts for less than 4 weeks, whereas PTSD lasts more than 4 weeks. PTSD also generally emphasizes avoidance symptoms, but these can overlap with dissociative symptomatology.
11The Three S’s of the Psychiatric Interview S – Stressors/triggersS – SuicidalityS – Substance Abuse
12Screening Questions“Over the last two weeks, how often have you been bothered by the following problems?”Feeling nervous, anxious, or on edgeNot being able to stop or control worrying0-not at all, 1-several days, 2-more than half the days, 3-nearly every dayScore of 2 or greater, has sensitivity of 0.86, and specificity of 0.70 for any anxiety disorderKroenke K et al. Anxiety Disorders in Primary care: Prevalence, Impairment, Comorbidity, and Detection. Ann Intern Med. 2007;146:
13Key QuestionsIs there an underlying medical disorder or substance abuse?Is the anxiety triggered (cued) or not?Are there panic attacks?
14Is the anxiety cued or uncued? Anxiety disordersIs the anxiety cued or uncued?No cuesCued (or triggered)Panic attacks?Specific object or situation specific phobiaSocial situation social phobiayesnoReminder of traumatic event PTSDclosed in spaces (no help) agoraphobiaOCD, GAD or Anx d/o nosPanic disorder
15Anxiety Disorders Epidemiology Assessment and Diagnosis Review of Anxiety DisordersTreatments
16Anxiety disorders Panic Disorder Agoraphobia Social Phobia (Social Anxiety Syndrome)Specific PhobiaObsessive-Compulsive DisorderPost-Traumatic Stress DisorderAcute Stress DisorderGeneralized anxiety disorderAdjustment disorder, with anxious featuresAnxiety Disorder, not other specified
17Panic Disorder Key Diagnostic Points Panic attacks can occur in a number of Anxiety Disorders in addition to Panic DisorderThe diagnosis of Panic Disorder requires the presence of recurrent unexpected (uncued) panic attacks.The uncued panic attacks of Panic Disorder can progress, over time to the cured attacks of Specific Phobia or Social Phobia (and vice versa).
18Panic Attacks: A Syndrome Not specific to Panic DisorderOccurs in social phobia, specific phobia, PTSD and OCDMay herald depressionMay be secondary to:underlying medical conditionmedication side effectillicit drug use
19Panic AttackEpisodes have a sudden onset and peak rapidly (usually in 10 minutes or less)Often accompanied by a sense of imminent danger or doom and an urge to escapeFrequently presents to ER with fear of catastrophic medical event (e.g., MI or stroke)
20Panic AttackDiscrete period of intense fear or discomfort accompanied by four or more of following:PalpitationsSweatingTremblingChokingChest painDizzy, faintDerealizationNumbnessChills or hot flashesFear of losing control, going crazyFear of dying, passing out
21Panic Disorder Recurrent unexpected panic attacks Followed by one or more of the following:Anticipation of additional attacksWorry about implications of attacksChange in behaviorWith or without Agoraphobia
22AgoraphobiaAnxiety about being in situations from which escape might be difficultUsually secondary to panic attacksAvoided situations include: driving, bridges, tunnels, elevators, airplanes, malls, long lines, sitting in middle of row, etc.
23Post-Traumatic Stress Disorder Requires history of traumaThree clusters of symptomsRe-experiencing (flashbacks, nm’s)Avoidance and numbingArousal (insomnia, hypervigilance)Duration of more than one month
24Obsessive-compulsive disorder Patient usually has obsessions and compulsions:Obsessions are recurrent and persistent thoughts, impulses, or images that are experienced, at some time during the disturbance, as intrusive and inappropriate and that cause marked anxiety or distress. The person recognizes that the obsessional thoughts, impulses, or images are a product of his or her own mind.Compulsions are repetitive behaviors or mental acts that the person feels driven to perform in response to an obsession, or according to rules that must be applied rigidly. Generally, they are not connected in a realistic way with what they are designed to neutralize or prevent, or are clearly excessive.
25Obsessive-compulsive disorder Treatments include:SSRI’s: usually high dose, take longer for effectClomipramine (Anafranil)Behavior Therapy:Exposure-Response Prevention4) Psychosurgery for treatment-refractory casesresponse preventionexposureIncreased anxietyobsessionscompulsionsdesensitizationDecreased anxiety
26Obsessive-compulsive disorder Typical obsessions:Typical compulsionsContamination: Fear of dirt or germs, bodily waste or fluids (a feeling of dirtiness)Repeated washing/cleaning, ritual behavior or thinkingOrdering: Concern with order, symmetry (balance) and exactnessConcern with order, symmetry (balance) and exactnessPerfectionism: Worry that a task has been done poorly, or a mistake has been madeChecking drawers, door locks and appliances to be sure they are shut, locked or turned off(see also hypochondriasis)Intrusive thoughts: blasphemous, sexual, violentRitual behavior or “superstitious thinking”“I might use it later.”hoarding
27Specific Phobia, Social Phobia, Acute Stress Disorder Anxiety Disorder, NOS Social Phobia (often overlaps with Avoidant Personality Disorder)Common, but often difficult to treatSpecific PhobiaUsually best treated with desensitization, but medication augmentation occasionally indicated
28Generalized Anxiety Disorder Excessive worries for at least six months about real life problems such as school and work performance.Accompanied by anxiety symptoms3 or more of the following:Restlessness or feeling keyed-up or on edgeEasy fatigabilityTrouble concentratingIrritabilityMuscle tensionSleep disturbance
29Case vignetteFor the past three months, a 38yo depressed man has been obsessed with thoughts that he is evil and guilty of being insensitive to others. He has intrusive thoughts that he should kneel down in front of his co-workers in the weekly staff meeting and ask their forgiveness. He tries to ignore these thoughts and suppress them by repeatedly counting the number of ceiling tiles in the room when the thoughts occur.He periodically recognizes that the concerns are excessive but he cannot control them.
30Case vignette Which ONE of following diagnoses is most likely? Post-traumatic stress disorderGeneralized anxiety disorderObsessive-compulsive disorderObsessive-compulsive personality disorderMajor depressive disorder
31Case vignette (answer) Which ONE of following diagnoses is most likely?Answer: e) Major depressive disorderGuilty ruminations may be part of a depressive syndrome and MDD takes precedence over OCD in this case. However, mood-incongruent obsessions (eg, sexual obsessions) might lead one to MDD co-morbid with OCD.OCD is different from OCPD.
32Anxiety Disorders Epidemiology Assessment and Diagnosis Review of Anxiety DisordersTreatments
33Case VignetteA 77yo male, widowed Chinese retired accountant, who is healthy except for mild hypertension and a history of chronic multiple somatic complaints, now complains of a “heavy head”, as well as ongoing complaints of anxiety, decreased energy and insomnia for the past several months or years (hx is vague). Screening neuro exam is unremarkable. Routine labs done two months ago are also noncontributory.
34Case Vignette Question Which of the following is the MOST appropriate in the management of this patient?The goal should be complete remission of symptoms.Initiate citalopram 20mg daily.Avoid discussing social issues with patient.Instruct patient to return to clinic for follow-up “as needed”.Instruct patient to go to Emergency Department “as needed”.
35Case Vignette Answers Discussed “Curing the patient” should not be the goal in this situationAntidepressants can be helpful for subclinical anxious syndromes.Focus on social issuesRegular visits decreases inadvertent reinforcement of symptom production.As above.
36Health Anxiety and Hypochondriasis Fear or belief of potential of serious illnessMisinterpretation of bodily sensationsPersists despite appropriate medical reassuranceLasts for at least six monthsVariant of OCD?(Fallon BA, Qureshi, AI, Laje G, Klein B: Hypochondriasis and its relationship to obsessive-compulsive disorder. Psychiatr Clin North Am 2000; 23: )Variant of OCD? Differs in two important waysOcd suffers think thoughts, obsessions are senseless and/or irrational and try to suppress themAlso, therefore tend to keep disorder private
37Hypochondriasis and Health Anxiety From the Greek hypochondriumAffected individuals frequently investigate symptoms through reading or the Internet (cyberchondria)“Every physical symptom must have an explanation.”
38Hypochondriasis and Health Anxiety Reassurance may reinforce fear, particularly if it reduce anxiety temporarily“Sick role” may reinforce behaviorsPhysical de-conditioning may increase somatic sensationsSocial isolation (eg, staying home from work) may worsen somatic preoccupation.
39Hypochondriasis: Treatment Possible treatment modalities include:SSRI’sCognitive-behavioral therapy (CBT)Education about health beliefsGreeven A, et al: Cognitive behavior therapy and paroxetine in the treatment of hypochondriasis: a randomized controlled trial. Am J Psychiatry 2007; 164:91-99Treating Health Anxiety: A Cognitive-Behavioral Approach, by Taylor and Asmundson, Guilford Publications, 2004
40Anxiety Disorders Epidemiology Assessment and Diagnosis Review of Anxiety DisordersTreatments
41Anxiety Disorder Treatments PsychotherapyPsychopharmacologicalEffectiveness = [efficacy of treatment] X [degree to which the patient is engaged in treatment]*Robustness = difficulty in administering a particular treatment(eg, pharmacotherapy more robust than psychotherapy)* I will turn to this issue in the workshop
42Psychotherapy of Anxiety Disorders Behavior TherapyAnxiety disorders are conceptualized as arising from avoidance behaviors. Therefore, treatment is directed at having the individual desensitize to avoided stimuli through exposure and other behavioral interventions. Internal mental states are relatively unimportant.Cognitive TherapyAnxiety disorders are conceptualized as arising from cognitive distortions. Thus, treatment is directed at changing unproductive or intrusive thought patterns. The individual examines his or her feelings and learns to separate realistic from unrealistic thoughts.Cognitive-Behavioral Therapy (CBT)Combination of cognitive and behavior therapies.Relaxation TechniquesRelaxation techniques help individuals develop the ability to cope more effectively with the stresses and physical symptoms contributing to anxiety (eg,breathing retraining and exercise).
43Self-Help Books for Anxiety Disorders Anxiety and Phobia Workbook, by E. BourneStop Obsessing, by E. Foavan Boeijen et al. Efficacy of self-help manuals for anxiety disorders in primary care: a systematic review. Fam. Pract. 22: , 2005.Bower P et al. The clinical and cost-effectiveness of self-help treatments for anxiety and depressive disorders in primary care: a systematic review. Br J Gen Pract 2001; 51: 838–845.Newman et al. Self-help and minimal-contact therapies for anxiety disorders: is human contact necessary for therapeutic efficacy? J Clin Psychol 2003; 59: 251–274.
44Websites Anxiety Disorders Association of America http://www.adaa.org/ The Anxiety and Phobia Internet Resouce (TAPIR)
46AntidepressantsSSRI’s (selective serotonin reuptake inhibitors)– first line (fairly safe in OD), recommend 9m minimum duration of treatmentside effects: a) “long term”: weight gain (moderate), sexual side effects (in around 35%)b) “short term”:nausea, diarrhea, headache, rash, insomnia, sweatingc) “serotonin syndrome” – usually in combo with two or more serotonergic agents: restlessness confusion, flushing, tremor progressing to hyperthermia, hypertonicity, rhabdomyolysis, deathFluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), fluvoxamine (Luvox), citalopram (Celexa), escitalopram (Lexapro)
47Antidepressants Other antidepressants Mirtazapine (Remeron): sedation and weight gainVenlafaxine (Effexor): Mixed NE and 5HT activity, increases BP, similar side effect profile to ssri’sDuloxetine (Cymbalta): Also mixed NE and 5HT activityBuproprion (Wellbutrin): low rate of sexual side effects or weight gain, associated with increase rate of seizures, not for use in patients with eating disorders, prior seizure d/oNefazodone (Serzone)5-HT2 blocker, often recommended for anxious depression, black box warning for liver failure, low rate of sexual se’sTrazodone (Desyrel) – usually prescribed as a hypnotic (ie, sleep aid)
48Anxiolytics Buspirone – partial agonist of 5HT1a 5-20mg tid, takes 2-6 weeksno w/d sx, easy to use, may be preferred in elderlyBenzo’s
50Anxiety Disorders Benzos Anxiolytics– benzodiazepines (BDZ)All share same mechanism of actionVary by speed of onset, metabolism and duration of actionShorter-acting usually means faster speed of onset: eg,alprazolam (Xanax)triazolam (Halcion)Longer-acting: diazepam (Valium), clonazepam (Klonopin), lorazepam (Ativan)
52Anxiety Disorders Benzos Anxiolytics– benzodiazepinesMain side effects include: sedation, ataxia, amnesia, potential for abuseGenerally useful for short-term anti-anxiety, tolerance frequently develops within 1-2 weeksShould not be discontinued abruptly (esp. shorter acting bdz’s): taper over 1-3 weeks
53BDZ’s and the geriatric patient: It’s not just about addition Benzodiazepines associated with:Sleep disturbanceCognitive difficultyImpairment in activities of daily livingMotor vehicle accidentsGait disturbance (with concomitant increased risk of hip fractures)[references next slide]
54References1. Hemmelgarn B, Suissa S, Huang A, Boivin JF, Pinard G. Benzodiazepine use and the risk of motor vehicle crash in the elderly. JAMA. 1997;278:27–31.2. Pomara N, Tun H, DaSilva D, Hernando R, Deptula D, Greenblatt DJ. The acute and chronic performance effects of alprazolam and lorazepam in the elderly: relationship to duration of treatment and self-rated sedation. Psychopharmacol Bull. 1998;34:139–53.3. Ried LD, Johnson RE, Gettman DA. Benzodiazepine exposure and functional status in older people. J Am Geriatr Soc. 1998;46:71–6.4. Wang PS, Bohn RL, Glynn RJ, Mogun H, Avorn J. Hazardous benzodiazepine regimens in the elderly: effects of half-life, dosage, and duration on risk of hip fracture. Am J Psychiatry. 2001;158:892–8.5. Glass J, Lanctot KL, Herrmann N, Sproule BA, Busto UE. Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits. BMJ. 2005;331:1169–73.6. Stewart S. The effects of benzodiazepines on cognition. J Clin Psychiatry. 2005;66 (suppl 2):9–13.
55Clinician Attitudes Geriatric patients have low rate of addiction. “If it works and she doesn’t abuse it, who cares?”Continuation is compassionate; discontinuation is harsh.“In the greater scheme of things I have a feeling there are other problems that are much, much worse.”Geriatric patients will be resistant to even discussing it.Tapering off benzodiazepines will require a lot of time.
56Getting patients off Benzo’s Does abruptly stopping a BDZ cause problems?180 chronically anxious patients rx’d for 6 weeks with diazepam (avg dose 25mg/d), then:a) switched to placebob) continued on diazepam for 8 more weeks, then switched to placeboc) continued on diazepam for 16 more weeks , then switched to placeboRickels, K K. Long-term diazepam therapy and clinical outcome. JAMA. Vol:250, no:6, page:767-71 1983.
57Getting patients off Benzo’s Results: only 2/61 (3%) in first group experienced withdrawalOther groups had 18% withdrawal rateMain predictive factor: duration of previous BDZ treatment >8 monthsIf >8m, withdrawal rate = 43%if <8m, withdrawal rate = 5%Rickels, K K. Long-term diazepam therapy and clinical outcome. JAMA. Vol:250, no:6, page:767-71 1983.
58Getting patients off Benzo’s Take home message:Short term usage (<6 weeks) unlikely to lead to significant problems with withdrawal.Patients who have been on BDZ’s for more than one year will need more careful tapering.Rickels, K K. Long-term diazepam therapy and clinical outcome. JAMA. Vol:250, no:6, page:767-71 1983.
59SummaryAnxiety Disorders are common in primary care and are frequently associated with somatic complaints.Screening for anxiety disorders can be done by two questions:“Over the last two weeks, how often have you been bothered by the following problems?”Feeling nervous, anxious, or on edge?Not being able to stop or control worrying?
60SummaryThere are a finite number of anxiety disorders (seven) and an accurate diagnosis leads to appropriate treatment.There are multiple efficacious treatments for anxiety disorders, both pharmacological and psychosocial.Patient engagement is a key factor is improving effectiveness.