1. Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc. Collaborative Drug Discovery, Inc. CDD Database Archive, Mine, and (selectively) Collaborate Collaborative Drug Discovery, Inc. Burlingame, CA

2. Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc. Who We Are A private company, founded in 2004. Products: CDD Vault, CDD Collaborate, CDD Public –CDD Agile Custom Services Working with thousands of leading researchers using CDD on six continents Provides secure cloud-based collaborative drug discovery embracing academic, non-profit, and for-profit company researchers (cultures) in invitation-only groups –Affordable, easy-to-use, yet extremely powerful SAB: –Christopher Lipinski, PhD (ex Pfizer) –James McKerrow, MD PhD –David Roos, PhD –Adam Renslo, PhD –Wes Van Voorhis, MD PhD –Jim Wikel (ex Eli Lilly)

3. Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc. CDD Successfully Builds Collaborative Drug Discovery Communities Published Review in Drug Discovery Today 2009 (14: 261-270). $1.89M Tuberculosis B&MGF Project Thousands of scientists engaged:

4. Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc. Typical Lab: The Data Explosion Problem

5. Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc. CDD Vault - the database for your private data

6. Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc. Collaborate Mode 1 – Big Pharma with single login to multiple CROs/Biotech groups Consolidated CDD DB Collaborator 1Collaborator 2 Collaborator 4 Collaborator 3

7. Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc. Collaborate Mode 2 – p2p Individual Labs securely sharing data subsets CDD DB group 1 CDD DB group 2 CDD DB group 3 CDD DB group 4

8. Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc. CDD Platform Integrated Product s: CDD Vault = Secure place for your own data CDD Collaborate = Ability to selectively share subsets of data with trusted colleagues CDD Public = Published Data collections, from the CDD community, Chemical Vendors, Scientific SAR you can mine with private data

9. Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc. Collaborative Dashboard for Secure To-the-Minute Global R&D Tracking

10. Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc. CDD Search Results View

11. Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc. Heat Maps, Controls, & Plate Statistics

12. Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc. CDD Vault and CDD Collaborate In the Cloud (log in securely into to your database from any computer). We host the server for you Highly secure, all traffic encrypted, server in a secure professionally hosted environment, encrypted backups, much more. Secure and low TCO

13. Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc. New Types of Offerings for a Rapidly Changing Industry CDD Community: tap into global R&D via crowd-sourcing –CDD proven TB example w/ the Bill & Melinda Gates Foundation CDD Alliance: better management of your collaborations CDD Customize: fast, good, and cost-effective = agile –Highly adaptable, innovative solutions – see p2p example: CDD Collaborate

14. Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc. Special thanks to ChemAxon: Marvin Calculator Plugins JChem Cartridge Flexible Toolkits for Modern Web Development –Ruby on Rails –Java –MySQL, Oracle, etc. Contact: Barry A. Bunin PhD Cell: (650) 219-4153 bbunin@collaborativedrug.com Collaborative Drug Discovery, Inc. bbunin@collaborativedrug.com www.collaborativedrug.com Acknowledgement & Contact