1. Cell Division SOL: BIO 6 a-c

2.  The student will investigate and understand common mechanisms of inheritance and protein synthesis.  Key concepts include:  a)cell growth and division;  b)gamete formation; and  c)cell specialization.

3. Cell Growth  In most cases, living things grow by producing more cells  The cells of an adult animal are no larger than the cells of a young animal, there are just more of them

4. Limits to Cell Growth  There are 2 reasons why cells divide instead of continuing to grow indefinitely  The larger a cell becomes, the more demands it places on its DNA  Also, the cell has more trouble moving enough nutrients & wastes across the cell membrane

5. Cell Division  Some cells divide constantly: cells in the embryo, skin cells, gut lining cells, etc. Epithelial Cell Intestinal Cell 7 week old embryo

6. Cell Division  Other cells divide rarely or never. Brain Cell – Nerve cell Spinal Cord Cell- Nerve cell Cardiac Cell (Heart Muscle)

7. Cell Division Vocabulary  somatic cell – a body cell; a cell whose genes will not be passed on to future generations.  sex or germ cell - a cell that is destined to become a gamete (egg or sperm); a cell whose genes can be passed on to future generations.

8. Cell Division Vocabulary  diploid (2N) – a cell with 2 chromosome sets in each of its cells; all body (somatic) cells  haploid (N) – a cell with 1 chromosome set in each of its cells; all gametes (sperm, eggs)

9. Cell Division  2 kinds of cell division:  1. Mitosis: division of somatic cells  2. Meiosis: creation of new sex cells Sperm cellsHuman egg cell Pancreatic cells

10. Cell Cycle  A typical cell goes through a process of growth, development, and reproduction called the cell cycle.  Most of the cycle is called interphase. INTERPHASE

11. Cell Cycle  The longest phase in the cell cycle is interphase.  The 3 stages of interphase are called G 1, S, and G 2.

12. Cell Cycle  Cells spend most of their time in G 1 : it is the time when the cell grows and performs its normal function.  Control of cell division occurs in G 1 : a cell that isn’t destined to divide goes into G 0.

13. Cell Cycle  The S phase (“Synthesis”) is the time when the DNA is replicated. Parent strands Daughter strands

14. Cell Cycle  G 2 is the period between S and mitosis.  DNA replication is checked and the cell is getting ready to divide.

16. Cell Division  All living cells come from other living cells.  During mitosis, the nucleus of the cell divides, forming two nuclei with identical genetic information.

17. Mitosis  Mitosis produces two genetically identical cells.  Mitosis is referred to in the following stages: prophase, metaphase, anaphase, and telophase.

18. Prophase  In prophase, the cell begins the process of division.  The chromosomes condense.

19. chromatin duplicated chromosome

20. Prophase  Nuclear envelope disappears.

21. Prophase  Centrioles migrate to opposite poles of the cell.  Asters and spindle fibers form. Aster and the mitotic apparatus in an animal cell

22. Draw Prophase

23. Prophase 3 4 5 1 2

24. Prophase 3 4 5 Centriole 2

25. Prophase 3 4 5 Spindle fibers

26. Prophase Aster 4 5 Centriole Spindle fibers

27. Prophase Aster Sister chromatids 5 Centriole Spindle fibers

28. Prophase Aster Sister chromatids Centromere Centriole Spindle fibers

29. Metaphase  The chromosomes line up at the equator of the cell (metaphase plate), with the centrioles at opposite ends and the spindle fibers attached to the centromeres. Centriole Spindle fibers Metaphase plate

31. Draw Metaphase

32. Anaphase  In anaphase, the centromeres divide.  At this point, each chromosome goes from having 2 sister chromatids to being 2 separate chromosomes

33. Anaphase  The spindle fibers contract and the chromosomes are pulled to opposite poles.

34. Draw Anaphase

35. Telophase  In telophase the cell actually divides.  The chromosomes are at the poles of the cell.  The nuclear envelope re- forms around the two sets of chromosomes.

36. Draw Telophase

37. Cytokinesis  The division of the cytoplasm.  In animal cells, a Cleavage Furrow forms and separates Daughter Cells Cleavage furrow in a dividing frog cell.

38. Cytokinesis  In plant cells, a Cell Plate forms and separates Daughter Cells. Cell Plate forming

39. ANIMAL VS. PLANT MITOSIS  ANIMAL CELL  Centriole and aster present  Daughter cells separated by cleavage furrow  PLANT CELL  No visible centriole or aster  Daughter cells separated by cell plate

40. Mitosis: Can you name the stages? 1 2 3 4 5

41. Prophase 2 3 4 5

42. Mitosis: Can you name the stages? Prophase Metaphase 3 4 5

43. Mitosis: Can you name the stages? Prophase Metaphase Anaphase 4 5

44. Mitosis: Can you name the stages? Prophase Metaphase Anaphase Telophase 5

45. Mitosis: Can you name the stages? Prophase Metaphase Anaphase Telophase Cytokinesis

46.  Phases of mitosis - IPMATC Interphase Cytokinesis

47.  Phases of mitosis - IPMATC I mportant P eople M ust A nalyze T asks C orrectly I mpatient P eople M ay A ttack T eachers C onstantly

48. Onion Root Mitosis