1. The PC Program captures drug exposures from participating PCs using a standard electronic system to record calls from the public; RADARS System personnel perform quality control checks to verify coding accuracy Included in analysis were intentional exposure (IE) cases and associated medical outcomes involving individuals 50 years of age and older IE cases from 1Q2009 – 2Q2010 were analyzed Cases involved: suspected suicide, misuse, abuse, intentional unknown, or withdrawal  Opioids: buprenorphine, fentanyl, hydrocodone, hydromorphone, oxycodone, oxymorphone, methadone, morphine, tapentadol, and tramadol  Stimulants: amphetamines and methylphenidate Multivariate logistic regression was used Covariates included; gender, age, methadone, opioids, multiple drug exposures Methadone use was separated from opioid use due to the potential differences between methadone abusers and other prescription drug abusers Model 1 explored associations between attempted suicide vs. other intentional exposure reasons (Figure 1) Model 2 explored associations between suicide completion vs. non-completion in a group subset from those used in model 1 (Figure 2) Suicidal Behaviors Involving Prescription Drugs in Individuals 50 Years of Age and Older as Identified by the RADARS® System Poison Center Program J Davis¹, H Miller¹, E Winter¹, R Dart 1,2, RADARS® System Poison Center Group 1 Rocky Mountain Poison & Drug Center - Denver Health, Denver, CO 2 University of Colorado School of Medicine, Aurora, CO Introduction Relationships between suicide attempts and completed suicides using prescription opioids and stimulants may vary by age and gender Objectives Compare suspected suicide vs. other intentional exposures involving opioid drug types and stimulants as reported to RADARS ® System Poison Center (PC) Program Evaluate risk factors for suicide attempts and suicide completions involving prescription opioids vs. stimulants Differentiate trends of suicide attempts and suicide completions ResultsConclusions Among individuals 50 years of age and older, the odds of a suicide attempt decrease with increasing age In this sample, multiple drugs exposure was not a significant risk factor for suicide attempt, but it was a significant risk factor for suicide completion RADARS ® System Participating Poison Centers Arizona Poison and Drug Information Center: Boesen K. Banner Good Samaritan Poison and Drug Information Center: Stevens D, Welch S. Blue Ridge Poison Center: Holstege CP, Bechtel LK, Wenger, KL. California Poison Control System: Alsop JA. Central Ohio Poison Center: Baker SD. Central Texas Poison Center: Borys D. Children’s Hospital of Michigan: Smolinske S. Cincinnati Drug and Poison Information Center: Bond GR, Pierce B. Connecticut Poison Control Center: McKay C, Sangalli B. Florida Poison Information Center – Jacksonville: Schauben JL, Sollee D. Florida Poison Information Center – Miami: Bernstein J, Weisman RS. Florida Poison Information Center – Tampa: Kimball T, Cullen T. Georgia Poison Center: Geller RJ, Wright N. Hennepin Regional Poison Center: Anderson D, Lintner C. Illinois Poison Center: Wahl M, DesLauries C, Kubic A. Indiana Poison Center: Mowry JB. Iowa Statewide Poison Control Center: Bottei E, Kalin L, Ringling S. Kentucky Regional Poison Center: Spiller HA. Long Island Regional Poison and Drug Information Center: Caraccio T, Jao D. – (closed December 2010) Louisiana Poison Center: Ryan M. Maryland Poison Center: Doyon S. Massachusetts/Rhode Island Poison Center: Burns Ewald M, Sheroff A. Missouri Regional Poison Center: Weber J, Enders S, Odom C. Nebraska Regional Poison Center: Jacobitz K, Rasmussen M. New Jersey Poison Information and Education System: Ruck B, Marcus S, Rego R. New York City Poison Control Center: Hoffman, R, Mercurio-Zappala, M. North Texas Poison Center: Abron D, Uzoegwu L, Gardner M. Northern New England Poison Center: Simone KE, Bubar J. Northern Ohio Poison Center: Aleguas A. Oklahoma Poison Control Center: McGoodwin L, Schaeffer S. Oregon Poison Center: Giffin S, McKeown N. Palmetto Poison Center: Michels J. Pittsburgh Poison Center: Krenzelok E, Kurta D. Regional Poison Control Center of Alabama: Liebelt E, Slattery A. Rocky Mountain Poison & Drug Center: Dart RC, Westberry RS. South Texas Poison Center: Fernández MC, Cobb DB, Villarreal, CL. Tennessee Poison Center: Kumar S. Texas Panhandle Poison Center: Jaramillo J, Rivers R. The Ruth A. Lawrence Poison & Drug Information Center Serving Finger Lakes: Barton N, McFarland S, Rekkerth D. – (closed December 2010) The University of Kansas Hospital Poison Control Center (KS): Lowry J, Oller L. Upstate New York Poison Center: Cantor, R, Stork, C, Caliva, M. Virginia Poison Center: Rose SR, Waring E. Washington Poison Center: Martin T, Chew A, Von Derau K. West Texas Regional Poison Center: Artalejo L, Baeza S. West Virginia Poison Center: Scharman EJ. Western New York Poison Center: Joshi P. – (closed December 2010) Wisconsin Poison Center: Kostic M. Suicide Attempt Associations Suicide Completion Associations odds ratio95% Clodds ratio95% Cl Female gender1.3231.212 - 1.4451.3540.812 – 2.257 Age (years)0.9840.979 - 0.9891.0230.995 – 1.050 Methadone0.6180.490 - 0.7801.7940.645 – 4.988 Opioids0.9660.773 – 1.2071.0710.340 – 3.372 Multiple drugs0.9550.925 – 1.1052.3921.267 – 4.514 Financial Support: The RADARS® System is a public non-profit organization providing post-marketing surveillance of prescription medications to pharmaceutical manufacturers. The authors are all employees of Denver Health and Hospital Authority, which operates the RADARS® System. Several manufacturers of controlled substances are subscribers to the RADARS® System. The authors have no direct financial relationships or non-financial relationships with pharmaceutical companies outside of their roles at the Rocky Mountain Poison & Drug Center. Methods 8,667 Intentional exposures met criteria Suicide AttemptsSuicide Completions 5,365 (61.9% of IEs)66 (1.2% of attempts) 58% female65% female mean age 57.7 (sd 8.0)mean age 59.0 (sd 7.6)