1. CRNnet PopMedNet Experience 7/27/2015 David Tabano Institute for Health Research Kaiser Permanente Colorado

2. Objectives Overview of CRNnet functionality What we’ve done Where we’re headed 2

3. Goal of CRNnet Provide network infrastructure to conduct rapid QA, prep-to-research (PTR) analyses across multiple research institutions within the CRN 3

4. Goal of CRNnet SAS Distribution- Establish quasi-automation of SAS queries through CRN – Enable users to manage CRN queries through PopMedNet (PMN) Datamart Client (DMC) 4

5. The DMC in CRNnet The DMC is a software application that communicates with CRNnet through a secure IP address – Essentially a secure file transfer software specifically calibrated for PMN networks Data, files are transferred over a secure https connection Requires user credentials Tested by KP IT under the SPAN grant for cross-site scripting, SQL injection, etc, and has since been improved further with additional Microsoft security applications 5

6. CRNnet Query Volume, Jan-Jul 2015 6

7. 7 PTR/QA requests, 1/2015 – 7/2015 TypeDescriptorSiteQueriedResponding (Business Days) PTR 1019KPNC 981.375 PTR 1020KPNC 540.5 PTR 1025GHC 1191.444 PTR 1028GHC 11103.4 PTR 1029KPNC 431.333 QA RADIOTHERAPYGHC 993.5 QA SMOKINGGHC 431 QA TUMOR STAGEGHC 10 4.778 PTR CRN Descriptive PaperGHC 7613.7 PTR CRC CRN PosterGHC 11 6.2 PTR 1033GHC 1190.8 PTR 1036GHC 1064.3 PTR 1037KPNC 1193 TOTAL 8.697.463.72

8. SAS Query Functionality Automated processing of SAS programs submitted through CRNnet AutomateSASbatch.bat – Command File (DOS executable) – Communicates between DMC and programs at local site; drives the entire query SAS WinZip/7Zip (where available) 8

9. Supporting Files SAS.exe EditSection.sas CRNnet Standard Vars.sas Current Query Folder.sas WinZip.exe – OPTIONAL- WinZip CommandLine, 7Zip can automate compression 9

10. SAS Distribution Query Processing 10 Local DMC receives query.bat initiates local programs Supporting files (SAS, WinZip, etc.) SAS runs query WinZip compresses, encrypts query DMC identifies output Site programmer manually reviews query results Site programmer uploads results back to CRNnet through DMC

11. Query through the DMC Pros – More contained, streamlined – More secure – More efficient Cons – Onboarding sites – Learning curve – SAS Distribution requires programs need to be correct on first run 11

12. CRNnet “Wish List” Summary query functionality underutilized Automated alerts (e.g. screen pop-ups) for notifications of queries More efficient tracking of requests related to the same project; link query “history” IT Support for site-specific issues 12

13. Websites and References https://healthdatacollaboration.net/ – CRNnet – HMORNnet – SPAN (archived) – Others http://crn.cancer.gov/ – Cancer Research Network 13

14. Contact Info CRN - cancer-research-network@kp.orgcancer-research-network@kp.org Technical Lead for SAS Distribution update – David Tabano, KPCO Institute for Health Research David.C.Tabano@kp.org 303-614-1348 Program Lead – Heather Clancy, KPNC Division of Research Heather.A.Clancy@kp.org 510-891-3663 14