1. BIOL 4320 Cellular Biology Rachna Sadana

2. Learning Goal Demonstrate knowledge of why cancer cells have replicative immortality? Learning Objectives 1. List Hallmarks of cancer cells 2a. Explain what are telomeres and why are these important (end replication problem) 2b. Explain mechanism of action of various cancer drugs. 3. Explain how telomerase inhibitors can work as anti- cancer drugs? 4. Analyze data from a paper showing telomerase activity in cancer cells. 5. How Herceptin and taxol work differently than telomerase inhibitors? 6. Design an experiment to test various compounds to screen for cytotoxic activity and telomerase inhibitory activity. Taxonomy Levels 1. Remember2. Understand3. Apply4. Analyze5. Evaluate6. Create Activity 1. Reading assignment outside class 2. Video lecture outside the class 3. Draw a model showing what happens if telomerase is active or inactive 4a. Data Analysis assignment as homework assignment 4b. Data analysis assignment for in-class discussion 5. in-class discussion on estrogen receptor signaling and inhibition by Herceptin role of tubulin in cell division and interference in cell cycle by taxol Mechanism of action of telomerase inhibitors and side effects 6. Take home assignment Formative Assessment 1. Online quiz part 1 on BbL (Sunday night) 2. Post on discussion board on BbL (Sunday night) 3. Scenario questions in- class 4. Homework assignment 5. Evaluate pros and cons of Herceptin, taxol and telomerase inhibitors 6. Take home assignment

3. SSu M F R WT S MF R WT Watch video lecture or guided reading assignment Online quiz and Post response to prompts on discussion board Instructor provides feedback to student’s posts. Interrupted lecture Group quiz Application activity on telomerase inhibitord Review of home work assignment Data Analysis from second paper Interrupted lecture Discussion on various cancer drugs (Jig- saw) Compare and contrast various cancer drugs Interrupted lecture on experimental design Discussion on homework assignment Watch video lecture or guided reading assignment Post response to prompts on discussion board Instructor provides feedback to student’s posts. Free day!! Problem set as home work on data analysis Week 1Week 2 Out-of class in class LO 1 and 2a Free day!! LO 4 LO 5 LO 3 LO 2b Experimental design Take home assignment due in a week LO 6 LO 4

4. Reflection: How am I floating? 6/17/2015?? June 2016