1. The OSU HHMI Med into Grad Scholars Program Joanna Groden Ph.D. COM, Associate Dean for Basic Science Ginny Bumgardner M.D., Ph.D. COM, Associate Dean for Research Education & Graduate Studies

2. Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is a medical research organization dedicated to biomedical research and science education. Its principal objectives are the advancement of fundamental knowledge in the biomedical sciences and the application of that knowledge to alleviate disease and promote health. Through its grants and special programs, HHMI seeks to strengthen science education and biomedical research by supporting current and future leaders to advance scientific knowledge, develop educational products, and implement outstanding educational practices.

3. Program Purpose T he Howard Hughes Medical Institute (HHMI) Med into Grad Initiative is designed to prepare Ph.D. researchers to conduct research at the interface of biomedical science and clinical medicine. T he Howard Hughes Medical Institute (HHMI) Med into Grad Initiative is designed to prepare Ph.D. researchers to conduct research at the interface of biomedical science and clinical medicine. Graduates of these programs are expected to expedite the clinical application of discoveries in biomedical science to improve human health and to create future successful research partnerships with physicians. Graduates of these programs are expected to expedite the clinical application of discoveries in biomedical science to improve human health and to create future successful research partnerships with physicians. The goal is to augment the biomedical applications of our traditional basic science research programs at OSU through the COM and through our newly funded CTSA. The goal is to augment the biomedical applications of our traditional basic science research programs at OSU through the COM and through our newly funded CTSA.

4. 2009 HHMI Med into Grad 23 Awardees 11 prior awardees*; 12 new Baylor* CCF/Case* Columbia Cornell Emory Harvard* Memorial Sloan Kettering Ohio State Univ Rice* UAB* UC San Diego UC Davis* UCSF* Univ Chicago UNC Chapel Hill* Univ Penn* Univ Rochester Univ Texas SW MC Dallas Univ Utah Univ Washington* Vanderbilt Yale*

5. The OSU HHMI Program focuses on six emphasis areas in the basic sciences. Biomedical Engineering Biomedical Engineering Computational Biology Computational Biology Genetics Genetics Infectious Disease Infectious Disease Neuroscience Neuroscience RNA Biology RNA Biology

6. Core Leadership Team Co-Directors: Joanna Groden PhD & Ginny Bumgardner MD PhD Co-Directors: Joanna Groden PhD & Ginny Bumgardner MD PhD Core Leadership Team: Core Leadership Team: Carlo Croce MD, Larry Schlesinger MD, Richard Hart PhD, Daniel R. Schoenberg PhD, John Oberdick PhD, Jeff Parvin PhD, Virginia Sanders PhD, and Rebecca Jackson MD. The centerpiece for the curricular aspects of the proposal is the COM Integrated Biomedical Sciences Graduate Program (IBGP) which offers a translational area of research emphasis. The centerpiece for the curricular aspects of the proposal is the COM Integrated Biomedical Sciences Graduate Program (IBGP) which offers a translational area of research emphasis.

7. Eligibility Requirements This program is offered on a competitive basis annually to 6 exceptional pre-candidacy graduate students at OSU: This program is offered on a competitive basis annually to 6 exceptional pre-candidacy graduate students at OSU: (1) who will have completed at least one year of training in their graduate program and (1) who will have completed at least one year of training in their graduate program and (2) whose dissertation research is relevant to at least one of 6 highlighted scientific disciplines including genetics, microbial biology, biomedical engineering, RNA biology, neuroscience or computational biology. (2) whose dissertation research is relevant to at least one of 6 highlighted scientific disciplines including genetics, microbial biology, biomedical engineering, RNA biology, neuroscience or computational biology. MD PhD dual degree students are not eligible. MD PhD dual degree students are not eligible.

8. Design of the Training Program  Focused preclinical training in the pathobiology of human disease relevant to the HHMI scholar’s research focus  Translational Science Coursework through course offerings in the COM Integrated Biomedical Science Graduate Program  Exposure/access to translational research coursework and core resources in the Center for Clinical and Translational Science (CCTS)  Mentored experiences within clinical services related to dissertation/disciplinary research by faculty in the OSU medical center (OSUMC) Appointment of a COM faculty member to the scholar’s dissertation committee  Graduate Certificate Program (in progress)

9. The OSU HHMI Scholar Benefits  Individualized Pre-clinical & Translational Science Curriculum  Interactions with CCTS  COM faculty on Dissertation Committee  Mentored Clinical experiences  ~12 experiences over 12 months  In-patient, out-patient, clinical trial, electronic records, laboratory, pathology, operating room, journal review, selected seminars and conferences, individual and group meetings)  Scientific networking with faculty, other research trainees and administrators in COM  Regional and/or National Networking

10. The OSU HHMI Scholar Benefits  Access to OSU HHMI Virtual Library through Educational Technology  Opportunity to present research and win travel awards at annual OSUMC Research Day  Selected scholars will receive one-year of stipend support: $30,000  1 year of Tuition expenses (exclusive of “special” fees such as the COTA, recreation, student activity fee, learning technology fee etc.)

11. The OSU HHMI Scholar has a structured 12 month curriculum.  Sample Qtr: HHMI Scholars Orientation meetingHHMI Scholars Orientation meeting Selected independent study on-line module related to the scholar’s disciplinary research (3 cr)Selected independent study on-line module related to the scholar’s disciplinary research (3 cr) Translational Science Course (3 cr)Translational Science Course (3 cr) Translational Seminar (1-3 cr)Translational Seminar (1-3 cr) Mentored Clinical Experience (1-3 cr)Mentored Clinical Experience (1-3 cr) Indep Research (3-7 cr)Indep Research (3-7 cr) Qtrly HHMI Scholars meeting/RetreatQtrly HHMI Scholars meeting/Retreat

12. OSU Partners Supporting the HHMI Med Into Grad Scholars Program HHMI HHMI OSU, Office of Research OSU, Office of Research OSU, Graduate School OSU, Graduate School OSU Clinical Center for Translational Science OSU Clinical Center for Translational Science OSU Medical Center OSU Medical Center College of Medicine College of Medicine College of Engineering College of Engineering College of Arts & Sciences College of Arts & Sciences