1. Ischemic Colitis
Ri 陳宏彰

2. Reference books Harrison’s online 15th
Marx: Rosen's Emergency Medicine: Concepts and Clinical Practice, 5th ed., Copyright © 2002 Mosby, Inc

3. Ischemic Colitis
Ischemia of the colon most often affects the elderly (90% of patients > 60 y/o ).
Ischemic colitis is almost always nonocclusive. (emboli are the most common cause of acute mesenteric ischemia)
Shunting of blood away from the mucosa may contribute to this condition, but the mechanism is unknown.

4. Ischemic Colitis
Most patients ischemia occurs secondary to arteriolar shunting, spasm, or poor perfusion of mucosal vessels.
Most cases involve the splenic flexure, which is supplied by end-arteries.
The rectum is usually spared, because its blood supply is different from the rest of the colon and less dependent on the inferior mesenteric artery .
Marx: Rosen's Emergency Medicine: Concepts and Clinical Practice, 5th ed

5. Types of Ischemic Colitis
Acute fulminant ischemic colitis
Subacute ischemic colitis
HARRISON’S ONLINE 15TH

6. Types of Ischemic Colitis
Gangrenous ischemic colitis
a complete loss of arterial flow causes bowel wall infarction and gangrene, which can progress to perforation, peritonitis, and death.
Stricturing ischemic colitis
a gross impairment of the arterial supply, leading to hemorrhagic infarction of the mucosa, which ulcerates, heals by fibrosis, and finally leads to stenosis.
Transient ischemic colitis
a transient, reversible impairment of the arterial supply, which causes a partial mucosal slough that heals by mucosal regeneration in a few days. the most common
Marx: Rosen's Emergency Medicine: Concepts and Clinical Practice, 5th ed

7. Acute fulminant ischemic colitis manifestations
The onset is characteristically acute, with generalized lower abdominal pain, usually in the left lower quadrant, followed within 24 hours by bloody diarrhea or rectal bleeding .
Dilation of the colon and physical signs of peritonitis are seen in severe cases.
With the gangrenous type, both symptoms and signs progress rapidly.

8. Acute fulminant ischemic colitis Diagnostic Strategy
No specific serum markers proven in the diagnosis of intestinal ischemia.
Abdominal films may reveal thumbprinting from submucosal hemorrhage and edema .
* (barium enema is contraindicated in cases of gangrenous ischemic colitis because of the risk of perforation )

9.                          
thumbprinting

10. Acute fulminant ischemic colitis Diagnostic Strategy
Sigmoidoscopy or colonoscopy may detect ulcerations, friability, and bulging folds from submucosal hemorrhage. (Colonoscopy is preferred over sigmoidoscopy )
The segmental distribution and rectal sparing of the disease process are suggestive but are not diagnostic.

11. Colonoscopic view showing marked erythema and exudate in sigmoid colon

12. Endoscopic view of mucosal edema, exudates, and ulcerations in sigmoid colon

13. Endoscopic image of descending colon showing severe colitis with pneumatosis intestinalis.

14. Acute fulminant ischemic colitis Diagnostic Strategy
Angiography is not helpful in the management of patients with presumed ischemic colitis because a remediable occlusive lesion is very rarely found.
CT scan is normal in early stages of bowel infarction, although it may show nonspecific findings such as bowel wall thickening and pneumatosis.

15. CT showing left sided colonic thickening.

16. Pneumatosis Intestinalis

17. Pneumatosis Intestinalis

18. Acute fulminant ischemic colitis management
When ischemic colitis is suspected, a surgeon should be consulted.
Gangrenous ischemic colitis or evidence of perforation requires immediate surgery as soon as the patient is stabilized.

19. management Vasopressors should be avoided, if possible.
Low blood-flow states (hypotension) should be aggressively reversed.

20. Types of Ischemic Colitis
Acute fulminant ischemic colitis
Subacute ischemic colitis

21. Subacute ischemic colitis manifestations
It produces lesser degrees of pain and bleeding, often occurring over several days or weeks.
The left colon may be involved, but the rectum is usually spared because of the collateral blood supply.

22. Subacute ischemic colitis management
Subacute Ischemic colitis without evidence of peritonitis or perforation is generally self-limited and requires only conservative management, including bowel rest, parenteral fluids, and antibiotics.

23. Subacute ischemic colitis management
Most cases of nonocclusive ischemic colitis resolve in 2 to 4 weeks and do not recur.
Surgery is not required except for obstruction secondary to postischemic stricture.

24. Differential Considerations
Ischemic colitis often mimics infectious colitis, inflammatory bowel disease, or even colon carcinoma.
Many cases of colitis in the elderly once considered to be Crohn’s disease or ulcerative colitis in retrospect were really colonic ischemia.

25. Differential Considerations
The features considered atypical in inflammatory bowel diseases , such as
1.segmental distribution of the disease, infrequent rectal involvement,
2.high rate of spontaneous recovery, low rate of recurrence,
3.lack of adequate response to usual inflammatory bowel disease therapy,
4.frequent progression to fibrotic stenosis with delayed obstruction
The features above are now recognized as characteristic of colonic ischemia.

26. Differential Considerations
Always consider the diagnosis of ischemic colitis whenever contemplating the diagnosis of inflammatory bowel disease in an elderly patient.

27. Differential Diagnosis
Clinical
Radiologic
Ulcerative colitis
Bloody diarrhea
Extends proximally from rectum; fine mucosal ulceration
Crohn’s colitis
Perianal lesions common; frank bleeding less frequent than in ulcerative colitis
Segmental disease; rectal sparing; strictures, fissures, ulcers, fistulas; small bowel involvement
Ischemic colitis
Older age groups; vascular disease; sudden onset, often painful
Splenic flexure; “thumb printing”; rectal involvement rare

28. Conclusions
Always consider the diagnosis of ischemic colitis whenever contemplating the diagnosis of inflammatory bowel disease in the elderly.
Thumbprinting of the colon on plain abdominal radiographs suggests ischemic colitis.
Surgical consultation is warranted in all cases of suspected ischemic colitis.

29. Thanx for your attention