1. Diabetic Foot Infection

2. Of all the late complications of diabetes, foot problems are probably the most preventable. Joslin, who wrote in 1934 that “diabetic gangrene is not heaven-sent, but earth-born

3. Approximately 5% to 10% of diabetic patients have had past or present foot ulceration, and 1% have undergone amputation

4. Foot infections Foot infections are among the
most common and serious complications of
diabetes mellitus.
Types of infection include
cellulitis, myositis, abscesses, necrotizing
fasciitis, septic arthritis, tendinitis, and
osteomyelitis.

5. Pathophysiology
Patients with diabetes are particularly susceptible to foot infection primarily because of neuropathy, vascular insufficiency, and diminished neutrophil function. Peripheral neuropathy has a central role in the development of a foot infection and it occurs in about 30 to 50 percent of patientswith diabetes.

8. Microbiology
The most common pathogens in acute, previously untreated, superficial infected foot wounds in patients with diabetes are aerobic gram-positive bacteria, particularly Staphylococcus aureus and beta-hemolytic streptococci (group A, B, and others).

9. Microbiology
Infection in patients who have recently received antibiotics or who have deep limb-threatening infection or chronic wounds are usuallycaused by a mixture of aerobic gram-positive, aerobic gram-negative (e.g., Escherichia coli, Proteus species, Klebsiella species), and anaerobic organisms (e.g., Bacteroides species, Clostridium species, Peptococcus and Peptostreptococcus species).

10. Key Components of the Comprehensive Diabetic Foot Examination
Dermatologic    Skin status: color, thickness, dryness, cracking    Sweating    Infection: check between toes for fungal infection    Ulceration    Calluses/blistering: hemorrhage into callus?

11. Musculoskeletal
   Deformity (e.g., claw toes, prominent metatarsal heads, Charcot joint)    Muscle wasting (guttering between metatarsals)    Assess whether shoes are appropriate for the feet (e.g., size, width)

12. Neurologic
   Ability to perceive pressure from a 10-g monofilament plus one of the following:    Vibration using 128-Hz tuning fork    Pinprick sensation    Ankle reflexes    Vibratory perception threshold

13. VASCULAR
Foot pulses    Ankle-brachial index, if indicated

14. Clinical Evaluation
existence, severity, and extent of infection, as well as vascular status, neuropathy, and glycemic control should be assessed in patients with a diabetic foot infection. Visible bone and palpable bone on probing are suggestive of underlying osteomyelitis in patients with a diabetic foot infection. Before an infected wound of a diabetic foot infection is cultured, any overlying necrotic debris should be removed to eliminate surface contamination and to provide more accurate results. Routine wound swabs and cultures of material from sinus tracts are unreliable and strongly discouraged in the management of diabetic foot infection. The empiric antibiotic regimen for diabetic foot infection should always include an agent active against Staphylococcus aureus, including methicillin-resistant S. aureus if necessary, and streptococci.

15. Meggitt–Wagner classification of
foot ulcers
Grade Description of the ulcer
Grade 0 Pre- or post-ulcerative lesion
completely epithelialized
Grade 1 Superficial, full thickness ulcer
limited to the dermis, not
extending to the subcutis
Grade 2 Ulcer of the skin extending
through the subcutis with
exposed tendon or bone and
without osteomyelitis or
abscess formation
Grade 3 Deep ulcers with osteomyelitis
or abscess formation
Grade 4 Localized gangrene of the toes
or the forefoot
Grade 5 Foot with extensive gangrene

16. CONFIRMING THE DIAGNOSIS
must be diagnosed clinically rather than bacteriologically The clinical diagnosis of foot infection is basedon Thepresence of purulent discharge from an ulcer or the classic signs of inflammation (i.e., erythema, pain, tenderness, warmth, or induration). Other suggestive features of infection include foul odor, the presence of necrosis, and failure of wound healing despite optimal managment

22. Arterial inflow is adequate Infection is treated appropriately
Arterial inflow is adequate Infection is treated appropriately. Pressure is removed from the wound and the immediate surrounding area.