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a key molecule in purine and pyrimidine biosynthesis
fig purines: where does all them darn atoms come from??
ETC. fig 22-33, sorta
fig 22-33, still inosine, built “on the ribose” to make IMP
fig and inosinate begat adenylate and xanthylate, and xanthylate begat guanylate…
fig regulation of the early steps of purine synthesis
pyrimidine biosynthesis orotate, built “off the ribose” fig 22-36
pyrimidine biosynthesis OTP then modified to CTP, etc
Two ways for mammals to make and/or use purines and pyrimidines 1) de novo synthesis (see above) 2) salvage pathways Ad + PRPPAMP + PP
Two ways for mammals to make and/or use purines and pyrimidines 1) de novo synthesis (see above) 2) salvage pathways hypoxanthine + PRPPIMP + PP Lesch-Nyhan disease
Two ways for mammals to make and/or use purines and pyrimidines 1) de novo synthesis (see above) 2) salvage pathways pyrimidine salvage is similar but not well understood in mammals…
fig inhibitors of glutamine amindo- transferases chemo- therapeutics
fig remember the “D” in DNA??? either or
what’s the difference between T and U?? fig 22-44
where the THF gets its methy... fig 22-44
fig inhibitors of dihydrofolate reductase cycle
catabolism of purines… fig xanthine oxidase
out with gout!!! 1735
fig out with gout!!! xanthine oxidase too active
fig out with gout!!! xanthine oxidase inhibitor
Diet and purines Prof David Perrett William Harvey Research Institute Barts & the London School of Medicine.
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1 NUCLEOTIDE METABOLISM Metabolism of pyrimidine nucleotides NUCLEOTIDE METABOLISM Metabolism of pyrimidine nucleotides Prof. Mária Sasvári Gergely Keszler.
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