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Nucleotide Metabolism. nucleotide nucleoside.

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Presentation on theme: "Nucleotide Metabolism. nucleotide nucleoside."— Presentation transcript:

1 Nucleotide Metabolism

2 nucleotide nucleoside

3

4

5 a key molecule in purine and pyrimidine biosynthesis

6 fig purines: where does all them darn atoms come from??

7 fig 22-33

8

9 ETC. fig 22-33, sorta

10 fig 22-33, still inosine, built “on the ribose” to make IMP

11 fig and inosinate begat adenylate and xanthylate, and xanthylate begat guanylate…

12 fig regulation of the early steps of purine synthesis

13 pyrimidine biosynthesis orotate, built “off the ribose” fig 22-36

14 pyrimidine biosynthesis OTP then modified to CTP, etc

15 fig 22-38

16 Two ways for mammals to make and/or use purines and pyrimidines 1) de novo synthesis (see above) 2) salvage pathways Ad + PRPPAMP + PP

17 Two ways for mammals to make and/or use purines and pyrimidines 1) de novo synthesis (see above) 2) salvage pathways hypoxanthine + PRPPIMP + PP Lesch-Nyhan disease

18 Two ways for mammals to make and/or use purines and pyrimidines 1) de novo synthesis (see above) 2) salvage pathways pyrimidine salvage is similar but not well understood in mammals…

19 fig inhibitors of glutamine amindo- transferases chemo- therapeutics

20 fig remember the “D” in DNA??? either or

21 what’s the difference between T and U?? fig 22-44

22 where the THF gets its methy... fig 22-44

23 more chemotherapeutics

24 fig inhibitors of dihydrofolate reductase cycle

25 catabolism of purines… fig xanthine oxidase

26 fig 22-45

27 out with gout!!! 1735

28 fig out with gout!!! xanthine oxidase too active

29 fig out with gout!!! xanthine oxidase inhibitor


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