1. Rabies, the Fury Virus

2. Pathogenesis Bite site striated muscle cells peripheral nervous system is exposed in neuromuscular spindles exposed sensory nerve endings and motor end plates

3. Pathogenesis (cont) Neuronal infection (towards the center) CNS Brain and Salivary Glands

4. Why it is so evasive There may be very little virus and virus antigen delivered to evoke an immune response There may be very little virus and virus antigen produced in muscle early in the infection and very little in the peripheral nerves and CNS.

5. Why it is the fury disease Virus enters the saliva an multiplies exponentially at the same time it causes a fury effect in the limbic system.

6. End result The virus enters the neocortex. –Causes the dumb stage –Death by respiratory distress

10. Control Immunization –currently spend 1 billion dollars in U.S. alone –looking for more effective drugs