1. Click to edit Master title style Click to edit Master subtitle style CLICKER QUESTIONS For CAMPBELL BIOLOGY, NINTH EDITION Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson © 2011 Pearson Education, Inc. The Chromosomal Basis of Inheritance Chapter 16 Questions prepared by Louise Paquin McDaniel College

2. © 2011 Pearson Education, Inc. Who conducted the X-ray diffraction studies that were key to the discovery of the structure of DNA? a) Griffith b) Franklin c) Meselson and Stahl d) Chargaff e) McClintock

3. © 2011 Pearson Education, Inc. How do the leading and the lagging strands differ? a)The leading strand is synthesized in the same direction as the movement of the replication fork, and the lagging strand is synthesized in the opposite direction. b)The leading strand is synthesized at twice the rate of the lagging strand. c)The lagging strand is synthesized continuously, whereas the leading strand is synthesized in short fragments that are ultimately stitched together. d)The leading strand is synthesized by adding nucleotides to the 3' end of the growing strand, and the lagging strand is synthesized by adding nucleotides to the 5' end.

4. © 2011 Pearson Education, Inc. The DNA Model What kind of evidence about the structure of DNA came from each of the following branches of science? a)physics b)chemistry c)biology

5. © 2011 Pearson Education, Inc. The Genetic Material If the result of the Hershey and Chase experiment had been that radioactive sulfur ( 35 S) was found inside the cells instead of radioactive phosphorous ( 32 P), what could have been concluded?

6. © 2011 Pearson Education, Inc. Semiconservative Replication Define and diagram “semiconservative” as it applies to DNA replication.

7. © 2011 Pearson Education, Inc. Replication If a segment of DNA (circular or linear) is able to replicate, it must include which of the following? a)two double helices b)at least one origin of replication c)at least 3 million nucleotide pairs d)two or more mutated regions e)a binding site for ligase

8. © 2011 Pearson Education, Inc. Replication Enzymes In what order do the following enzymes and polypeptides function during replication? a)single-strand binding proteins b)DNA polymerase III c)helicase d)primase e)topoisomerase f)ligase g)DNA polymerase I

9. © 2011 Pearson Education, Inc. Replication Where and how is a new nucleotide added to the DNA strand during replication? What enzyme is needed?

10. © 2011 Pearson Education, Inc. Telomeres Telomeres, or the ends of linear chromosomes, have special structure and function, even though they are non-coding. Describe their structure and function.

11. © 2011 Pearson Education, Inc. Shortened Ends What enzyme does a gamete-producing cell include that compensates for replication- associated shortening? a)DNA polymerase II b)ligase c)telomerase d)DNA nuclease e)proofreading enzyme

12. © 2011 Pearson Education, Inc. Packaging Arrange the following in order of size, from smallest to largest. a)scaffolded domains b)double helix c)metaphase chromosome d)nucleosome e)30 nm fiber

13. © 2011 Pearson Education, Inc. Heterochromatin Which of the following is true of heterochromatin but not of euchromatin? a)It is accessible to enzymes needed for gene expression. b)It becomes less tightly compacted after cell division. c)It includes DNA primarily found in expressed genes. d)It appears more pale when observed microscopically. e)It remains tightly coiled at the G 1 phase.