1. VectorBase Invertebrate Vectors of Human Pathogens

4. Lots of data out there… Data on: Distribution of vectors and their ecology Insecticide resistance Transmission capacity For diseases:,, Malaria, Chagas, Dengue, Lymph. filariasis, etc. Projects funded by: Innovative Vector Control Consortium - IVCC The WHO/Gates Foundation Vector Biology and Control Project - VBC African Network on Vector Research - ANVR Marathon Oil (and other private investors) And several more, including national programmes Problems: Fragmentation of data; Secrecy; Independence; “Dialects” and syntax; etc.

5. Intelligent Databases Open access Intelligent Databases Open access The answer, is... Interoperability Efficient searches Decision Support Systems

7. 3610 (2392 unique)

8. IRBase

9. The example of Insecticide Resistance: Aedes aegypti, 2098 records

10. The example of Insecticide Resistance: Aedes aegypti, 2098 records

11. The example of Insecticide Resistance: Aedes aegypti - DDT, 133 records

12. The example of Insecticide Resistance: Anopheles gambiae, 771 records

13. The example of Insecticide Resistance: A. gambiae - DDT, 198 records

14. The example of Insecticide Resistance: A. gambiae - permethrin, 190 records

15. OBI/MIRO: assay MIRO: resistance assay CHEBI: insecticide is_aparticipates_in MIRO: Organism MIRO: resistance VB_CV: genotype PATO: Phenotype VB_CV/MIRO: Mosquito population GAZ: Geolocation IDOMAL: Human population IDOMAL: Transmission detection assay IDOMAL: Human biting rate Sporozoite rate Parous rate Vectorial capacity IDOMAL: Human biting rate Sporozoite rate Parous rate Vectorial capacity ENVO : Environmental conditions e.g. Rice field, Irrigation scheme, swamp, altitude, av. temperature, annual rainfall, av. humidity ENVO : Environmental conditions e.g. Rice field, Irrigation scheme, swamp, altitude, av. temperature, annual rainfall, av. humidity GAZ: Country, Province, District, GPS coordinates GAZ: Country, Province, District, GPS coordinates OBI/MIRO: collection assay IDOMAL: Season IDOMAL: Season Season + Geolocation + Human population + Mosq. population is_a has_input has_output is_a has_output is_a has_input has_member has_quality is_a has_quality is_about located_in IDOMAL: Malaria control measures

16. OBI/MIRO: assay MIRO: resistance assay CHEBI: insecticide is_aparticipates_in MIRO: Organism MIRO: resistance VB_CV: genotype PATO: Phenotype VB_CV/MIRO: Mosquito population GAZ: Geolocation IDOMAL: Human population IDOMAL: Transmission detection assay IDOMAL: Human biting rate Sporozoite rate Parous rate Vectorial capacity IDOMAL: Human biting rate Sporozoite rate Parous rate Vectorial capacity ENVO : Environmental conditions e.g. Rice field, Irrigation scheme, swamp, altitude, av. temperature, annual rainfall, av. humidity ENVO : Environmental conditions e.g. Rice field, Irrigation scheme, swamp, altitude, av. temperature, annual rainfall, av. humidity GAZ: Country, Province, District, GPS coordinates GAZ: Country, Province, District, GPS coordinates OBI/MIRO: collection assay IDOMAL: Season IDOMAL: Season Season + Geolocation + Human population + Mosq. population is_a has_input has_output is_a has_output is_a has_input has_member has_quality is_a has_quality is_about located_in IDOMAL: Malaria control measures

17. OBI/"VIRO": assay "VIRO": resistance assay CHEBI: insecticide is_aparticipates_in "VIRO": Organism "VIRO": resistance VB_CV: genotype PATO: Phenotype VB_CV/"VIRO": Vectorpopulation GAZ: Geolocation "VIRO": Human population "IDOVBD": Transmission detection assay "IDOVBD": Transmission data relating to vectors of other vector-borne diseases "IDOVBD": Transmission data relating to vectors of other vector-borne diseases ENVO : Environmental conditions e.g. Rice field, Irrigation scheme, swamp, altitude, av. temperature, annual rainfall, av. humidity ENVO : Environmental conditions e.g. Rice field, Irrigation scheme, swamp, altitude, av. temperature, annual rainfall, av. humidity GAZ: Country, Province, District, GPS coordinates GAZ: Country, Province, District, GPS coordinates OBI/"VIRO": collection assay "IDOVBD": Disease control measures "IDOVBD": Season "IDOVBD": Season Season + Geolocation + Human population + Vector population is_a has_input has_output is_a has_output is_a has_input has_member has_quality is_a has_quality is_about located_in “VBDbase” "IDOVBD": Additional data models "IDOVBD": Additional data models “Oth_Ont2”: Additional data models “Oth_Ont2”: Additional data models “Oth_Ont1”: Additional data models “Oth_Ont1”: Additional data models

19. PopGen in VectorBase  George Christophides, with Bob MacCallum and Seth Redmont  Kitsos Louis, with Emmanuel Dialynas and Pantelis Topalis A new section of VB being developed that will house data on the population biology of anophelines, as well as data on malaria transmission and IR.  George Christophides, with Bob MacCallum and Seth Redmont  Kitsos Louis, with Emmanuel Dialynas and Pantelis Topalis A new section of VB being developed that will house data on the population biology of anophelines, as well as data on malaria transmission and IR.

20. UO GAZ PATO IDOMAL VBCV IDOMAL Linking PopGen and ontologies; Phenotypes, IR, transmission and popu- lation/ecology data Linking PopGen and ontologies; Phenotypes, IR, transmission and popu- lation/ecology data Soon to come in VectorBase!

21. TGMA – Mosquito Anatomy Ontology; CARO/BFO TADS – Tick Anatomy Ontology; CARO/BFO MIRO – Ontology of Insecticide Resistance; (move) to IDOMAL IDOMAL – Malaria Ontology; IDO/BFO VBCV – Ontology/CV for “completion” of PopGen IDOMAL extension, “IDOChagas”, PLO (Parasite Lifecycle) with Priti Parykh, Chris Stoeckert et al. TGMA – Mosquito Anatomy Ontology; CARO/BFO TADS – Tick Anatomy Ontology; CARO/BFO MIRO – Ontology of Insecticide Resistance; (move) to IDOMAL IDOMAL – Malaria Ontology; IDO/BFO VBCV – Ontology/CV for “completion” of PopGen IDOMAL extension, “IDOChagas”, PLO (Parasite Lifecycle) with Priti Parykh, Chris Stoeckert et al.

25. LOGICAL THOUGHT IS NOT A PRIVILEGE OF A FEW IT’S AN OBLIGATION FOR EVERYONE !!! LOGICAL THOUGHT IS NOT A PRIVILEGE OF A FEW IT’S AN OBLIGATION FOR EVERYONE !!!

26. Thank you!