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Current Malaria Related Operational Research Activities in Ethiopia Amha Kebede Deputy Director, EHNRI.

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Presentation on theme: "Current Malaria Related Operational Research Activities in Ethiopia Amha Kebede Deputy Director, EHNRI."— Presentation transcript:

1 Current Malaria Related Operational Research Activities in Ethiopia Amha Kebede Deputy Director, EHNRI

2 National strategic Plan FMoH developed strategic plan for – elaborates prevention and control directions – implementation strategies Objective – 100% ITN coverage 2007 (LLINs) – Universal coverage for malaria Dx & Rx by 2008 – 60% IRS in epidemic prone areas by 2010

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5 Co-artem distribution

6 On the parasite 1.A study on the efficacy of Coartem® in the treatment of uncomplicated Plasmodium falciparum malaria in two endemic areas, Ethiopia FMOH/Global Fund for malaria

7 On the parasite… 2.Molecular surveillance of drug resistance markers in Plasmodium falciparum field isolates from endemic areas, Ethiopia Molecular technology transfer for the detection and monitoring levels of drug resistance in P. falciparum Monitor allele frequencies of mutations in Pf genes associated with drug resistance following withdrawal of CQ & SP 3.Lab-based QC Testing of Malaria RDTs in Ethiopia

8 On the vector 1.Insecticide susceptibility/resistance study on important malaria vectors of Ethiopia resistance against DDT(all sites) and malathion (1 site) susceptible for Delthamethrin & permethrin 2.Evaluating the residual efficacy of Permanet®2.0 distributed 18 months previously in some malarious areas of Ethiopia 83.3% effectivity

9 On the vector…. 3.Evaluating the Efficacy of Deltamethrin 2.5% WDP for Malaria Vector Control as a Residual Indoor Spray reduced the indoor resting density of Anopheles mosquitoes by an average of 89.4%. Contact bioassays performed show the insecticide deltamethrin 2.5% WDP to persist for at least 3 months with an average killing effect of 96.5% on walls 4.The influence of socio-economic, environmental and cultural factors on the efficacy of PermaNet® in Ethiopia

10 Challenges : Financial constraints Capacity building at institution and regional level Mosquito & blood meal identification and resistance mechanisms & infection rate determination using molecular techniques Absence of collaborators


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